Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography

Grulkowski, Ireneusz; Manzanera, Silvestre; Cwiklinski, Lukasz; Mompeán, Juan; Castro, Alberto de; Marı́n, José Marı́a; Artal, Pablo

doi:10.1364/boe.9.003821

Cited by 39 publications

(26 citation statements)

References 42 publications

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“…Some investigators have proposed the use of two-dimensional 50 – 53 or three-dimensional 54 OCT images to grade the scattering produced by the nucleus of the lens and have found a positive correlation with the subjective clinical lens opacification scale using a slit lamp. Recently, Grulkowski et al demonstrated that a custom-built 3-D OCT scanner enabled volumetric visualization of the detailed structure in the human crystalline lens in vivo and suggested that 3-D OCT is a useful tool for high-resolution evaluation and management of crystalline lens opacities in cataract patients 55 . Chen et al 52 and Panthier et al 56 demonstrated IOLMaster 700, a widely available 2-D OCT scanner on clinical setting, is a reliable and repeatable method for assessment of cataract compared to LOCS III scale, Scheimpflug imaging or double-pass aberrometry.…”

Section: Discussionmentioning

confidence: 99%

A Purkinje image-based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo

Eto

Teikari

Najjar

et al. 2020

Sci Rep

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A method for rapid and objective assessment of ocular lens density and transmittance is needed for research and clinical practice. The aim of this study was to determine whether the Purkinje image-based technique can be used for objective and accurate quantification of spectral density and transmittance of ocular media (the mainly crystalline lens) in visible light. Twenty-six individuals (10 young, 9 middle-aged and 7 older individuals) participated in this study. Spectral lens density was evaluated by detecting the intensity of the IVth Purkinje image for different wavelengths. Subsequently, optical density index (ODI), the area under the curve in the lens density spectrum, was calculated and ODIs were compared with clinical lens opacification scales assessed subjectively using a slit lamp. Spectral lens transmittance was estimated from the lens density spectrum. Lens densities were higher in the short wavelength region of the visible spectrum across all age groups. ODI was highly correlated with the clinical opacification scale, while lens transmittance decreased with aging. Our results showed that spectral transmittance of the human crystalline lens can be easily estimated from optical density spectra evaluated objectively and rapidly using the Purkinje image-based technique. Our results provide clinicians and scientists with an accurate, rapid and objective technique for quantification of lens transmittance.

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Section: Discussionmentioning

confidence: 99%

A Purkinje image-based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo

Eto

Teikari

Najjar

et al. 2020

Sci Rep

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show abstract

“…In addition to the fixation target, volunteer's movements are limited by the use of a dental impression. Figure 2 shows two OCT images of crystalline lenses affected by cataract [18,19]. Some regions remain transparent with the spatial distribution depending on the type of cataract.…”

Section: Methodsmentioning

confidence: 99%

Single-pixel imaging of the retina through scattering media

Dutta

Manzanera

Gambín-Regadera

et al. 2019

Biomed. Opt. Express

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Imaging the retina of cataractous patients is useful to detect pathologies before the cataract surgery is performed. However, for conventional ophthalmoscopes, opacifications convert the lens into a scattering medium that may greatly deteriorate the retinal image. In this paper we show, as a proof of concept, that it is possible to surpass the limitations imposed by scattering applying to both, a model and a healthy eye, a newly developed ophthalmoscope based on single-pixel imaging. To this end, an instrument was built that incorporates two imaging modalities: conventional flood illumination and single-pixel based. Images of the retina were acquired firstly in an artificial eye and later in healthy living eyes with different elements which replicate the scattering produced by cataractous lenses. Comparison between both types of imaging modalities shows that, under high levels of scattering, the single-pixel ophthalmoscope outperforms standard imaging methods.

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“…Due to its high-detection sensitivity, OCT technology allows detecting reflected signals of 5 × 10 −10 of the incident average laser power using only 20 μW [36]. The use of OCT in ophthalmology was first applied to visualize the human retina, emerging as a powerful complement of fundus photography in the interpretation and diagnosis of retinal diseases [37][38][39][40] and assessment of cataracts [41,42].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

An Update on Corneal Imaging Techniques: from Macroscale to Nanostructure

Ávila

Ares

Collados

et al. 2019

SN Compr. Clin. Med.

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The structural integrity of the cornea and transparency are critical for normal vision. Corneal evaluation in ophthalmology and clinical research requires fast and user-friendly techniques allowing accurate diagnoses and follow-up of pathologies, injuries or surgery. Macroscopic irregularities in the anterior corneal surface are the main cause of irregular refractive vision problems. The microscopic and nanoscopic irregularities within the three-dimensional architecture of cornea are the cause of loss of optical transparency and scattering. In this review, the state of the art of the different corneal imaging techniques with three-dimensional capabilities will be detailed and discussed according to the descriptive level of analysis: macroscopic, microscopic and nanoscopic scales.

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Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography

Cited by 39 publications

References 42 publications

A Purkinje image-based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo

A Purkinje image-based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo

Single-pixel imaging of the retina through scattering media

An Update on Corneal Imaging Techniques: from Macroscale to Nanostructure

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