Volumetric findings of MRI after platelet rich plasma injection in knee osteoarthritis (A randomized clinical trial)

Raeissadat, Seyed Ahmad; Ghorbani, Elham; Rayegani, Seyed Mansoor; Taheri, Mohammad; Babaee, Marzieh; Soleimani, Reza

doi:10.1016/j.rehab.2018.05.022

Annals of Physical and Rehabilitation Medicine

2018

DOI: 10.1016/j.rehab.2018.05.022

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Volumetric findings of MRI after platelet rich plasma injection in knee osteoarthritis (A randomized clinical trial)

Seyed Ahmad Raeissadat

Elham Ghorbani

Seyed Mansoor Rayegani

et al.

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2024

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Orthobiologics in knee osteoarthritis, dream or reality?

Budhiparama,

Putramega,

Lumban-Gaol

2024

Arch Orthop Trauma Surg

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Cartilage restoration or repair, also known as orthobiologic therapy, is indicated after the failure of conservative or supportive treatment. However, there is paucity in evidence supporting the efficacy of orthobiologic therapy. The blood-derived products, such as platelet-rich plasma (PRP), is one of the commonly used orthobiologic therapy for knee osteoarthritis. Several studies have shown that PRP is superior to other treatments, but the anatomic changes are scarce. Treatment with mesenchymal stem cells (MSCs) offers the greatest potential for curing degenerative disease due to their self-renewal ability, ability to migrate towards injured tissues (homing/trafficking), and ability to promote repair and regeneration of osteochondral defects. However, ethical concerns and high costs remain major challenges associated with MSC therapy. Gene therapy, another promising orthobiologic therapy, is currently in phase II clinical trial and has shown promising results. The key factors for successful orthobiologic therapy include patient selection, appropriate dosing, treatment of underlying mechanical problems, age, severity, and cost-effectiveness.

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Orthobiologics in knee osteoarthritis, dream or reality?

Budhiparama,

Putramega,

Lumban-Gaol

2024

Arch Orthop Trauma Surg

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Volumetric findings of MRI after platelet rich plasma injection in knee osteoarthritis (A randomized clinical trial)

Cited by 1 publication

References 0 publications

Orthobiologics in knee osteoarthritis, dream or reality?

Orthobiologics in knee osteoarthritis, dream or reality?

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