Volumetric bone mineral density using peripheral quantitative computed tomography in Japanese women

Hasegawa, Yusuke; Kushida, Kazuhiro; Yamazaki, Kaoru; Inoue, Tetsuo

doi:10.1007/bf01622288

Cited by 31 publications

(23 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our Japanese population the annual rate of bone loss was 1.28% in BD, which is within the range of bone loss in a Caucasian population, whereas the annual percent change of TBD was 71.37%, which is higher than that reported in a Caucasian population. After age 50 years there was a decline of 1.1% per year in both BD and TBD in the previous study of Japanese women [31], which is in good agreement with the results of our study. The overall decrease in BD between the ages of 50 and 79 years was 28.6% in our study and 32% in the other report [31].…”

Section: Discussionsupporting

confidence: 95%

“…After age 50 years there was a decline of 1.1% per year in both BD and TBD in the previous study of Japanese women [31], which is in good agreement with the results of our study. The overall decrease in BD between the ages of 50 and 79 years was 28.6% in our study and 32% in the other report [31]. In this study we asked whether bone mass measurement and the geometric parameters of bone at the ultradistal radius by pQCT can discriminate women with vertebral fractures, irrespective of the lack of regional specificity, and attempted to identify the cut-off level most effective for the discrimination of spinal fracture.…”

Section: Discussionsupporting

confidence: 95%

“…There have been studies that employed radial pQCT for spinal fracture risk estimation, with variable results where either a similar or a lesser efficiency of pQCT was shown in a Caucasian population. However, there have been very few reports on the Japanese population measured using pQCT [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Gorai

Nonaka²,

Kishimoto

et al. 2001

Osteoporos Int

View full text Add to dashboard Cite

In spite of the benefits of bone mass measurement by dual-energy X-ray absorptiometry (DXA), the use of DXA has limitations. It is unable to assess a true bone density, and cannot discriminate between the trabecular and cortical bone compartments. Ultradistal radius bone density was measured using peripheral quantitative computed tomography (pQCT) to determine reference values for total bone density (BD), trabecular bone density (TBD), polar strength strain index (pSSI), total bone mineral content (BC), trabecular bone mineral content (TBC), cortical bone density (CBD), cortical bone mineral content (CBC) and polar cross-sectional moment of inertia (pCSMI) in the Japanese female population, and to ascertain the cut-off values of the measured indicators that could most efficiently discriminate osteoporotic subjects with vertebral fractures. A total of 5266 healthy Japanese women aged 20-89 years were included in this study to determine Japanese reference values. Additionally, 621 who had undergone radiographic examination of the thoracic and lumbar spine at the time of pQCT measurement were selected to determine the cut-off values of BD, TBD, pSSI and other indicators for vertebral fractures. All the healthy subjects were divided into 5 year age groups. The BD showed nonsignificant changes from the 20-24 year age group to the 45-49 year age group, and fell significantly thereafter. The TBD maintained a plateau until the 40-44 year group, which corresponds to the young adult mean (YAM) values of the lumbar spine, femoral neck and radius BMDs measured using DXA. The TBD decreased significantly thereafter. The pSSI did not change significantly from the 20-24 year age group to the 45-49 year age group, and decreased slightly in the 50-54 year age group and markedly after 55-59 years. The cut-off values for the discrimination of vertebral fractures were obtained by the calculation of sensitivities, specificities and the area under the curves obtained using age-adjusted receiver operating characteristics (ROC) analysis. Odds ratios and 95% confidence limits (CL) were calculated using age-adjusted logistic analysis. The cut-off values for vertebral fractures, the area under the ROC curves (AUC) and odds ratios were 270.1 mg/cm3 (-2.2 SD, 66.6% of YAM), 0.689+/-0.025, 2.10 (1.63, 2.70) for BD, 104.8 mg/cm3 (-2.2 SD, 53.5% of YAM), 0.699+/-0.023, 2.17 (1.69, 2.77) for TBD and 192.8 mm3 (-1.9 SD, 59.8% of YAM), 0.631+/-0.028, 1.72 (1.34, 2.21) for pSSI, respectively. These findings suggest that ultradistal radius BMD measured using pQCT can be used to discriminate women with vertebral fractures.

show abstract

Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 95%

See 1 more Smart Citation

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Gorai

Nonaka²,

Kishimoto

et al. 2001

Osteoporos Int

View full text Add to dashboard Cite

show abstract

“…Recent studies have demonstrated that radial BMD using SPA, DXA and pQCT can differentiate between normal and osteoporotic women [21][22][23][24]. The differences between the pQCT values of premenopausal women and osteoporotic women in our study were expressed as T-scores ( Table 4).…”

Section: Discussionmentioning

confidence: 96%

Estimation of the Architectural Properties of Cortical Bone Using Peripheral Quantitative Computed Tomography

Hasegawa

Schneider

Reiners

et al. 2000

Osteoporosis International

Self Cite

View full text Add to dashboard Cite

We assessed the volumetric bone mineral density (vBMD) and cross-sectional architecture of cortical bone at the distal radius by peripheral quantitative computed tomography (pQCT). The volumetric bone mineral density [integral bone mineral density (BMDi), trabecular bone mineral density (BMDt) and cortical with subcortical bone mineral density (BMDsc)] and the architectural parameters [cortical bone area (CBA), cortical thickness (C-th), moment of inertia (Im) and polar moment of inertia (Ip)] were measured in 115 healthy premenopausal women, 48 osteoporotic postmenopausal women and 78 age-matched healthy postmenopausal women. Age-matched healthy women had higher values of vBMD and architectural parameters at the distal radius than osteoporotic women. Premenopausal women had higher values of vBMD and architectural parameters at the distal radius than postmenopausal women. The differences in the architectural parameters between age-matched healthy women and osteoporotic women were more pronounced when only the high density area (threshold 0.70 cm(-1)) was included. However, the differences in architectural parameters between premenopausal women and postmenopausal women were significant using even the lowest threshold value of 0.50 cm(-1) in the calculation. Receiver operating characteristic (ROC) curves were constructed and the areas under the curves calculated to evaluate the discriminating power of vBMD and architectural parameters. Comparison of the different ROC curves showed no statistical significance. In conclusion, our results suggest that both the density and mass distribution of the radius were clearly different between the healthy women and osteoporotic women. The differences in architectural parameters were more useful for studying the pathophysiology of osteoporosis than for contributing to the diagnosis. Determination of the cross-sectional mass distribution of bone combined with BMD should offer more information than BMD alone in the study of the pathophysiology of osteoporosis.

show abstract

“…이 중 DEXA를 통해 요추 및 대퇴부의 골밀도를 측정하여 골다공증 여부를 판단하는 것이 가장 일반화된 진단 방법이다 [6]. DEXA는 오차율 3% 이내의 비교적 높은 정확도를 제공하고 [7], 측정이 용이하여 골다 공증을 판단하기 위한 우수성 모델(Gold Standard)로 간주 되어 왔다 [8].…”

Section: 실험대상(명)unclassified

Prediction of Osteoporosis using Compositive Analysis of Trabecular Patterns on Proximal Femur

Lee¹,

Park²,

Jeong³

et al. 2012

The KIPS Transactions:PartB

View full text Add to dashboard Cite

The purpose of this study was to determine the evaluation parameters' osteoporosis predictability in accordance with measuring regions by analyzing the correlations between bone mineral density and trabecular patterns derived from different measuring regions. Experimental subjects were a total of 40 female patients after menopause aged over 40 years, and were classified into 20 control and 20 osteoporotic groups according to the T-score. Bone mineral density was measured on femoral neck, trochanter and ward's triangle by DEXA(Dual Energy X-ray Absorptiometry). We designated ROI(Region of Interest) with 50 x 50 pixel size on each measuring regions, and extracted trabecular patterns by using existing image processing method. We also selected a total of eight evaluation parameters that are categorized into structural(mean gray level, area, perimeter, thickness and terminal distance), skeletonized parameters(number, length) and fractal dimension. As a result, it was observed that area, perimeter, thickness, terminal distance, number, length and fractal dimension reflected the bone mineral density with high statistical validity(p<0.003). We also confirmed that the evaluation parameters could predict the osteoporosis more efficiently.

show abstract

Volumetric bone mineral density using peripheral quantitative computed tomography in Japanese women

Cited by 31 publications

References 18 publications

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Estimation of the Architectural Properties of Cortical Bone Using Peripheral Quantitative Computed Tomography

Prediction of Osteoporosis using Compositive Analysis of Trabecular Patterns on Proximal Femur

Contact Info

Product

Resources

About