Volumetric and Acoustic Behavior of Sodium Cyclamate in Aqueous System from 293.15 K to 318.15 K

Nowadays, imperative efforts have been made to advance the drug performance, which leads to the discovery of novel drug preparations and delivery systems. An understanding of the interactions between drug molecules and biological membranes at the molecular level is necessary for the best design of such procedures. The choice of acceptable and suitable manufacturing chemicals in the pharmaceutical areas is made possible by the thermodynamic investigation, which offers comprehensive information on interactions. The aim of this work is measure the density and speed of sound data for two antibiotics drugs cefazolin sodium (CFZ.Na), and ceftriaxone sodium (CFT.Na) in aqueous solutions of the amino acids (glycine, L-alanine, and Lleucine) at temperature ranges 293.15−308.15 K. By correlation of the experimental data, some valuable thermodynamic parameters, i.e., apparent molar volume ,V φ , and apparent molar isentropic compressibility, κ φ were calculated. The Redlich-Meyer equation was used for fitting of these parameters. In addition, apparent molar isobaric expansion, E φ 0 , and Hepler's constant, (∂ 2 V φ 0 /∂T 2 ) P , were computed from the temperature dependency of density data. The values of Hepler's constant are indicated by the structure-making tendency of the drugs. Also, the co-sphere overlap model was employed to interpret the relation between hydrophilic-hydrophilic and ion-hydrophilic interactions, between drugs and amino acids.

Section: Resultsmentioning

confidence: 99%

Exploring Interactions between Antibiotics Drugs and Amino Acids through Volumetric and Ultrasonic Properties at Different Temperatures

Abedi,

Shekaari,

Mokhtarpour

et al. 2024

“…Temperature dependence of V φ 0 values can be defined by the following equation V φ 0 = A + italicBT + C T 2 where A , B , and C are empirical constants that are calculated by the least-squares fitting of the standard partial molar volume at studied temperatures. , …”

Section: Resultsmentioning

confidence: 99%

“…where A, B, and C are empirical constants that are calculated by the least-squares fitting of the standard partial molar volume at studied temperatures. 39,40 On the basis of the derivative of standard partial molar volume V φ 0 from eq 3 as a function of temperature and at constant pressure, the standard apparent molar expansibilities E φ 0 were computed, which are given in Table 4. The values of E φ 0 are positive for LiBr in aqueous PIL solutions.…”

Section: T H Imentioning

confidence: 99%

Effect of Lactate-Based Protic Ionic Liquids on the Thermodynamic and Transport Properties of Aqueous Lithium Bromide Solutions at Different Temperatures

Mousavi,

Shekaari,

Ghaffari

et al. 2023

In recent years, there has been a growing interest in the utilization of protic ionic liquids (PILs) as a type of environmentally sustainable green solvent in various applications, including absorption refrigeration systems that involve lithium bromide. To gain a comprehensive understanding of the thermophysical properties of lithium bromide in water and aqueous solutions containing three different protic ionic liquids (PILs) composed of the cations 2-hydroxyethylammonium, bis(2-hydroxyethyl)ammonium, and tris(2-hydroxyethyl)ammonium, in combination with the lactate anion, a thorough investigation was conducted using ultrasonic, volumetric, and viscometric methods. The analysis of these thermophysical properties is crucial, as it allows for the examination of the underlying forces at play within the liquid mixtures. In this particular study, key thermophysical parameters, such as apparent molar volume, apparent molar isentropic compressibility, and viscosity coefficients, were investigated for both lithium bromide in water and its aqueous solutions containing PILs. The findings revealed a significant influence of solute−solvent interactions in the studied systems, which were observed to intensify with increasing concentrations of PILs. These outcomes are discussed in relation to hydrophilic−hydrophilic and ion−hydrophilic interactions, along with an analysis of the associated thermodynamic parameters. The cosphere overlap model was employed to interpret the positive transfer values observed in the experimental data.

“…The larger values at high temperatures and for ternary systems probably refer to the release of the solvent molecules to the bulk. In this respect, the V φ 0 values are correlated with a second-degree polynomial as the following equation V φ 0 = A + italicBT + C T 2 The temperature dependency of V φ 0 could be determined using empirical A , B , and C values. − The temperature dependency of the standard partial molar volume was determined as a derivative of V φ 0 with respect to the temperature and named the isobaric standard partial molar expansibility E φ 0 . These values have been reported for gabapentin in Table .…”

Section: Resultsmentioning

confidence: 99%

Density and Speed of Sound for Dilute Binary and Ternary Mixtures of Gabapentin with Surfactant Ionic Liquids Based on Ethanolamine Laurate in Aqueous Solutions at Different Temperatures

Bagheri,

Shekaari,

Mokhtarpour

et al. 2023

Ethanolamine-based ionic liquids have emerged as cost-effective and environmentally friendly green solvents with a wide diversity of applications. Extensive research around these solvents was focused on improving pharmaceutical products, leading to the discovery of novel drug formulations and delivery systems containing these ionic liquids. Understanding the intermolecular interactions between drugs and these neoteric solvents is crucial for designing effective processes. Thermodynamic investigations provide deep insights into these interactions and help us selecting suitable solvent system for pharmaceuticals. The density and speed of sound data of mixtures containing gabapentin in aqueous solutions of 2-hydroxyethylammonium laurate, bis-2-hydroxyethylammonium laurate, and tris-2-hydroxyethylammonium laurate were determined over a temperature range of (288.15 to 318.15) K. The apparent molar properties, such as apparent molar volumes, V φ , and apparent molar isentropic compressibility, κ φ , were calculated. It's worth noting that the V φ and κ φ values increase with both temperature and SAILs concentration, and the order of this increase is as follows:. Also, the apparent molar isobaric expansion, E φ 0 , and Hepler's constant were computed from the density data. The experimental V φ and κ φ values has been fitted to the Redlich−Meyer equation in the porpuse of obtaining important quantities such as standard partial molar volume, V φ 0 , and partial molar isentropic compression, κ φ 0 .