Density and Speed of Sound for Dilute Binary and Ternary Mixtures of Gabapentin with Surfactant Ionic Liquids Based on Ethanolamine Laurate in Aqueous Solutions at Different Temperatures

Abstract

Ethanolamine-based ionic liquids have emerged as cost-effective and environmentally friendly green solvents with a wide diversity of applications. Extensive research around these solvents was focused on improving pharmaceutical products, leading to the discovery of novel drug formulations and delivery systems containing these ionic liquids. Understanding the intermolecular interactions between drugs and these neoteric solvents is crucial for designing effective processes. Thermodynamic investigations provide deep insights into these interactions and help us selecting suitable solvent system for pharmaceuticals. The density and speed of sound data of mixtures containing gabapentin in aqueous solutions of 2-hydroxyethylammonium laurate, bis-2-hydroxyethylammonium laurate, and tris-2-hydroxyethylammonium laurate were determined over a temperature range of (288.15 to 318.15) K. The apparent molar properties, such as apparent molar volumes, V φ , and apparent molar isentropic compressibility, κ φ , were calculated. It's worth noting that the V φ and κ φ values increase with both temperature and SAILs concentration, and the order of this increase is as follows:. Also, the apparent molar isobaric expansion, E φ 0 , and Hepler's constant were computed from the density data. The experimental V φ and κ φ values has been fitted to the Redlich−Meyer equation in the porpuse of obtaining important quantities such as standard partial molar volume, V φ 0 , and partial molar isentropic compression, κ φ 0 .

Effect of Ionic Liquid Choline Lactate on Thermodynamic and Transport Properties of Amino Acids Glycine, l-Alanine, and l-Phenylalanine

“…Its presence disrupts the natural solvent structure, resulting in a more significant volume increase with temperature compared with pure solvent. This can happen due to breaking hydrogen bonds or introducing steric hindrance within the solvent network. ,,, true( ∂ E φ 0 ∂ T true) P = true( ∂ 2 V φ 0 ∂ T 2 true) P = 2 C …”

“…Choosing the appropriate solvent for investigating materials relies on several critical criteria, including biodegradability, bioavailability, eco-friendly, and eco-compatibility. − These characteristics are typically lacking in conventional solvents due to their high vapor pressure, toxicity, and flammability. − On the other hand, ILs are the most promising substitute for conventional solvents due to their easy synthesis, tunability, and low vapor pressure. The tunability feature of ILs is a unique property that enables them to be versatile in any reaction media, making them task-specific and surpassing conventional solvents in this regard. − Choline-based ILs are of particular interest in pharmaceutical and chemical industries due to their biodegradability and low toxicity. − Previous studies have investigated various systems involving amino acids and choline-based ILs.…”