Volume reduction of the entorhinal cortex in subjective memory impairment

Jessen, Frank; Feyen, Ludger; Freymann, Katrin; Tepest, Ralf; Maier, Wolfgang; Heun, Reinhard; Schild, H.H.; Scheef, Lukas

doi:10.1016/j.neurobiolaging.2005.10.010

Cited by 253 publications

(234 citation statements)

References 33 publications

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“…This is especially true in cognitively normal patients, with test-retest reliability varying as much as 0.38-0.65 for the MMSE [45]. In patients with Alzheimer's disease, subjective memory complaints have been shown to correlate with dementia-related anatomical changes, but predate decreases in MMSE scores, raising more concern about the sensitivity to detect mild impairment [46]. While objective testing targeting more specific domains of cognition such as declarative memory, attention, processing speed, visuoperception, and motor speed have also failed to show impairment in function with statin use, strength of evidence varies and the sensitivity for these tests for drug-related adverse effects is unknown [29].…”

Section: Limitations To Systematic Reviewsmentioning

confidence: 99%

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

Swiger¹,

Martin²

2015

Drug Saf

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Section: Limitations To Systematic Reviewsmentioning

confidence: 99%

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

Swiger¹,

Martin²

2015

Drug Saf

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“…Thus, although differences are not found in neuropsychological test scores in comparison with a 'healthy' group, some neuroimaging studies in people with SMC showed a smaller entorhinal cortex (Jessen et al 2006), a reduced hippocampal volume (Van der Flier et al 2004), reduced metabolism (Mosconi et al 2008) and subcortical parieto-occipital white matter lesions (Stenset et al 2008). Studies of brain activity during cognitive tasks note that subjects with SMC present an increase in activity in comparison with the control group (Rodda et al 2009;Rodda et al 2010;Maestu et al 2010;Jessen et al 2010;Elfgren et al 2010;Gallassi et al 2010;Benito-León et al 2010;Luck et al 2010).…”

Section: Introductionmentioning

confidence: 98%

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

Bajo

Castellanos

López

et al. 2011

AGE

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It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.

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“…In addition, researchers have begun to study a group of individuals with a history of cognitive complaints (CC) and mildly declining function, who do not yet perform 1.5 SD below the mean of healthy controls on psychometric memory tests. Research from our lab and others [57,65] indicates these individuals show structural and functional brain changes intermediate between MCI and HCs, and may be classified as "pre MCI." Therefore, inclusion of both objective and subjective memory assessments may confer an advantage over existing screens in terms of the ability to detect and characterize a wider spectrum of older adults presenting with significant cognitive complaints and/or actual performance deficits.…”

Section: Discussionmentioning

confidence: 85%

The Memory and Aging Telephone Screen: Development and preliminary validation

Rabin

Saykin

Wishart

et al. 2007

Alzheimer's & Dementia

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Background-Telephone interviews are widely used in geriatric settings to identify eligible research participants and to perform brief follow-up assessments of cognition. This article reports on the development and validation of the Memory and Aging Telephone Screen (MATS), a structured interview for older adults with mild cognitive impairment and/or significant memory complaints. We also developed three alternate forms of the MATS objective memory test to reduce practice effects engendered by multiple administrations.Methods-Participants were enrolled in a longitudinal study that included 120 older adults with amnestic mild cognitive impairment (MCI), subjective cognitive complaints (CC) but without deficit on neuropsychological tests, and demographically-matched healthy controls (HC). An additional 15 patients with mild probable Alzheimer's disease (AD) completed the alternative forms study. All participants received the original MATS version, and a subset (n = 90) later received two of three alternate forms.Results-The MATS was sensitive to group differences and the alternate forms were equivalent. MATS objective memory test scores showed adequate stability over one year and were moderately correlated with scores on a widely used list-learning test (CVLT-II).Conclusions-The MATS, a repeatable telephone screen that includes objective and subjective memory assessments, is useful for detecting individuals in the preclinical and early stages of dementia. Results encourage use of the MATS as a reliable and valid cognitive screening tool in research and clinical settings. Longitudinal assessments are being performed to investigate the predictive validity of the MATS for cognitive progression in MCI.

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Volume reduction of the entorhinal cortex in subjective memory impairment

Cited by 253 publications

References 33 publications

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

The Memory and Aging Telephone Screen: Development and preliminary validation

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