2006
DOI: 10.1016/j.neurobiolaging.2005.10.010
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Volume reduction of the entorhinal cortex in subjective memory impairment

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Cited by 259 publications
(238 citation statements)
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“…This is especially true in cognitively normal patients, with test-retest reliability varying as much as 0.38-0.65 for the MMSE [45]. In patients with Alzheimer's disease, subjective memory complaints have been shown to correlate with dementia-related anatomical changes, but predate decreases in MMSE scores, raising more concern about the sensitivity to detect mild impairment [46]. While objective testing targeting more specific domains of cognition such as declarative memory, attention, processing speed, visuoperception, and motor speed have also failed to show impairment in function with statin use, strength of evidence varies and the sensitivity for these tests for drug-related adverse effects is unknown [29].…”
Section: Limitations To Systematic Reviewsmentioning
confidence: 99%
“…This is especially true in cognitively normal patients, with test-retest reliability varying as much as 0.38-0.65 for the MMSE [45]. In patients with Alzheimer's disease, subjective memory complaints have been shown to correlate with dementia-related anatomical changes, but predate decreases in MMSE scores, raising more concern about the sensitivity to detect mild impairment [46]. While objective testing targeting more specific domains of cognition such as declarative memory, attention, processing speed, visuoperception, and motor speed have also failed to show impairment in function with statin use, strength of evidence varies and the sensitivity for these tests for drug-related adverse effects is unknown [29].…”
Section: Limitations To Systematic Reviewsmentioning
confidence: 99%
“…Thus, although differences are not found in neuropsychological test scores in comparison with a 'healthy' group, some neuroimaging studies in people with SMC showed a smaller entorhinal cortex (Jessen et al 2006), a reduced hippocampal volume (Van der Flier et al 2004), reduced metabolism (Mosconi et al 2008) and subcortical parieto-occipital white matter lesions (Stenset et al 2008). Studies of brain activity during cognitive tasks note that subjects with SMC present an increase in activity in comparison with the control group (Rodda et al 2009;Rodda et al 2010;Maestu et al 2010;Jessen et al 2010;Elfgren et al 2010;Gallassi et al 2010;Benito-León et al 2010;Luck et al 2010).…”
Section: Introductionmentioning
confidence: 98%
“…In addition, researchers have begun to study a group of individuals with a history of cognitive complaints (CC) and mildly declining function, who do not yet perform 1.5 SD below the mean of healthy controls on psychometric memory tests. Research from our lab and others [57,65] indicates these individuals show structural and functional brain changes intermediate between MCI and HCs, and may be classified as "pre MCI." Therefore, inclusion of both objective and subjective memory assessments may confer an advantage over existing screens in terms of the ability to detect and characterize a wider spectrum of older adults presenting with significant cognitive complaints and/or actual performance deficits.…”
Section: Discussionmentioning
confidence: 85%