Volume of the posterior hippocampus mediates age-related differences in spatial context memory and is correlated with increased activity in lateral frontal, parietal and occipital regions in healthy aging

Snytte, Jamie; Fenerci, Can; Rajagopal, Sricharana; Beaudoin, Camille; Hooper, Kiera; Olsen, Rosanna K.; Rajah, M. Natasha

doi:10.1016/j.neuroimage.2022.119164

Cited by 18 publications

(17 citation statements)

References 127 publications

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“…Interestingly, Johnson et al (2009) found that cortical reinstatement effects in occipitotemporal regions supported both detailed recollection and more general recognition memory. However, increased activity in parahippocampal and inferior parietal has explicitly been observed during spatial context memory tasks (Ankudowich et al, 2016; Diana et al, 2013; Hayes et al, 2007; Snytte et al, 2022). LV2 PLS results also indicated that older Post-Meno females exhibited lower levels of bilateral occipitotemporal, parahippocampal and inferior parietal cortex activity at encoding and retrieval, which was correlated with lower spatial context memory and higher recognition memory.…”

Section: Discussionmentioning

confidence: 99%

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Crestol,

Rajagopal,

Lissaman

et al. 2023

Preprint

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Reductions in the ability to encode and retrieve past experiences in rich spatial contextual detail (episodic memory) are apparent by midlife – a time when most females experience spontaneous (natural) menopause. Yet, little is known about how menopause status and chronological aging influence the functional brain networks associated with episodic memory. Female-specific investigations of memory-related brain function at midlife are thus warranted to advance our knowledge of how menopause and chronological aging affect cognitive brain aging in middle-aged females. We conducted an event-related task fMRI study of episodic memory for spatial context and used multivariate partial least squares (PLS) to investigate how chronological age and retrieval accuracy correlated with brain activity in 31 middle-aged premenopausal (age range: 39.55 – 53.30 yrs,Mage= 44.41 yrs,SDage= 3.12 yrs) and 41 middle-aged postmenopausal females (age range: 46.70 to 65.14 yrs,Mage= 57.05 yrs,SDage= 3.93 yrs). Behaviorally, both advanced age and postmenopausal status contributed to lower spatial context memory. PLS analysis of the fMRI data indicated that premenopausal, but not postmenopausal, females exhibited a positive correlation between lateral PFC, midline cortical, and angular gyrus activity during retrieval and spatial context memory performance. Also, only postmenopausal females advanced age was correlated with decreased activity in occipitotemporal, parahippocampal, and inferior parietal during encoding and retrieval and poorer spatial context memory performance. Our results highlight that both menopause and chronological aging affect episodic memory and related brain function in middle-aged females.Significance StatementThis study advances our understanding of how menopause status and chronological age affect memory-related brain function in middle-aged females. Using data driven multivariate partial least squares (PLS) regression for behavioral analysis and PLS correlation for fMRI analysis we found: 1) advanced age and post-menopause status negatively affected spatial context memory, 2) Only premenopausal females exhibited overlap in encoding and retrieval activity in angular gyrus, midline cortical regions, and prefrontal cortex, which correlated with better spatial context retrieval accuracy, and 3) age was correlated with reduced encoding and retrieval activity in occipitotemporal, parahippocampal, inferior parietal in only post-menopause, and this was associated with poorer spatial context memory.

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Section: Discussionmentioning

confidence: 99%

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Crestol,

Rajagopal,

Lissaman

et al. 2023

Preprint

Self Cite

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“…For instance, the ratio of pHipp volume to that of the aHipp was positively correlated with item-context retrieval [183]. Another study from the same group reported the volume of the pHipp as the mediator between age and spatial context memory performance [184]. Moreover, in children who performed a colour context encoding task while being scanned, recruitment of the pHipp was observed during context encoding, while those who had been exposed to interpersonal violence showed impaired memory of contexts (realistic background scenes) associated with violence [185].…”

Section: Discussionmentioning

confidence: 99%

Altered Resting-State Functional Connectivity in the Anterior Versus Posterior Hippocampus in Post-traumatic Stress Disorder: The Central Role of the Anterior Hippocampus

Chaposhloo

Nicholson

Becker

et al. 2022

Preprint

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Background: Post-traumatic stress disorder can be viewed as a memory disorder, with trauma-related flashbacks being a core symptom. Given the central role of the hippocampus in autobiographical memory, surprisingly, there is mixed evidence concerning altered hippocampal functional connectivity in PTSD. We shed light on this discrepancy by considering the distinct roles of the anterior versus posterior hippocampus and examine how this distinction may map onto whole-brain resting-state functional connectivity patterns among those with and without PTSD. Methods: We first assessed whole-brain between-group differences in the functional connectivity profiles of the anterior and posterior hippocampus within a publicly available data set of resting-state fMRI data from n =31 male Vietnam War veterans diagnosed with PTSD and n =29 age-matched combat-exposed male controls. Next, the connectivity patterns of each subject within the PTSD group were correlated with their PTSD symptom scores. Finally, the between-group differences in whole-brain functional connectivity profiles discovered for the anterior and posterior hippocampal seeds were used to prescribe post-hoc ROIs, which were then used to perform ROI-to-ROI functional connectivity and graph-theoretic analyses. Results: The PTSD group showed increased functional connectivity of the anterior hippocampus with affective brain regions (anterior/posterior insula, orbitofrontal cortex, temporal pole) and decreased functional connectivity of the anterior/posterior hippocampus with regions involved in processing bodily self-consciousness (supramarginal gyrus). Notably, decreased anterior hippocampus connectivity with the posterior cingulate cortex /precuneus was associated with increased PTSD symptom severity. The left anterior hippocampus also emerged as a central locus of abnormal functional connectivity, with graph-theoretic measures suggestive of a more central hub-like role in those with PTSD compared to trauma-exposed controls. Conclusions: Our results highlight that the anterior hippocampus plays a critical role in the neurocircuitry underlying PTSD and underscore the importance of the differential roles of hippocampal sub-regions in serving as biomarkers of PTSD.

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“…Age-related changes in the brain were traditionally believed to affect all brain regions equally; however, it is increasingly clear that these changes are region-specific ( 54 , 55 ). The most affected areas are the frontal cortex and parts of the hippocampal system, regions involved in executive function, learning and memory ( 47 , 56 , 57 ). Indeed, the age-associated loss of gray matter (consisting of neuronal cell bodies) with age is especially evident in the lateral prefrontal cortex, hippocampus, cerebellum, and caudate nucleus; and the shrinkage of white matter (consisting of myelinated axons) is seen to be particularly prevalent in the prefrontal cortex ( 54 ).…”

Section: Physiological and Functional Changes In The Aging Adultmentioning

confidence: 99%

Nutritional and lifestyle management of the aging journey: A narrative review

Kassis¹,

Fichot

Horcajada

et al. 2023

Front. Nutr.

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With age, the physiological responses to occasional or regular stressors from a broad range of functions tend to change and adjust at a different pace and restoring these functions in the normal healthy range becomes increasingly challenging. Even if this natural decline is somehow unavoidable, opportunities exist to slow down and attenuate the impact of advancing age on major physiological processes which, when weakened, constitute the hallmarks of aging. This narrative review revisits the current knowledge related to the aging process and its impact on key metabolic functions including immune, digestive, nervous, musculoskeletal, and cardiovascular functions; and revisits insights into the important biological targets that could inspire effective strategies to promote healthy aging.

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Volume of the posterior hippocampus mediates age-related differences in spatial context memory and is correlated with increased activity in lateral frontal, parietal and occipital regions in healthy aging

Cited by 18 publications

References 127 publications

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Altered Resting-State Functional Connectivity in the Anterior Versus Posterior Hippocampus in Post-traumatic Stress Disorder: The Central Role of the Anterior Hippocampus

Nutritional and lifestyle management of the aging journey: A narrative review

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