Voltammetry and Flow Injection Analysis with Amperometric Detection for Sensitive Sodium Metamizole Determination on Glassy Carbon Electrode Modified with SWCNTs/Nafion

Abstract

Novel, rapid and high sensitive voltametric methods and flow injection analysis were proposed for the determination of sodium metamizole on glassy carbon electrode modified with single-walled carbon nanotube with Nafion composite film. The results showed that SWCNT/Nafion remarkably enhanced the oxidation of metamizole which improved the anodic peak current of metamizole significantly. Under the optimized conditions peak current was proportional to sodium metamizole concentration in the range from 0.15 to 5 μM (DPV method) and from 20 to 100 μM (FIA method). The detection limit was 13 nM for DPV and 0.4 μM for FIA determination. The RSD for proposed methods were equal to 4.1% (n = 9) and 2.4% (n = 7) for voltammetry and FIA measurement respectively. Proposed methods were successfully validated by studying the recovery of metamizole in drugs and urine.

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

“…While the performance of the ePADs is below other references , two advantages need to be highlighted. First, ePADs were prepared and used without any modification with nanomaterials or charge transfer mediators.…”

“…In general, the LOD values achieved in our study are higher than most of the data found in the literature. As can be seen in Table S3, the LODs reported in the literature for paracetamol, metamizole and midazolam ranged between 10 À5 À10 À10 mol L À1 [59-64], 10 À5 À10 À8 mol L À1 [64][65][66], and 10 À5 À10 À7 mol L À1 [67,68], respectively. On the other hand, the detectability levels obtained for metamizole and midazolam using ePADs were slightly better than those found in two reports.…”

“…While the performance of the ePADs is below other references [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68], two advantages need to be highlighted. First, ePADs were prepared and used without any modification with nanomaterials or charge transfer medi- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 ators.…”

Highly Sensitive Adsorptive Stripping Voltammetric Method for Sitagliptin Determination on Renewable Amalgam Film Electrode

“…Different modifiers might be used for their modifications, for example zeolites, [32][33][34] inorganic substances (metal oxides, salts) 35,36 or carbon nanomaterials. 37 Modified solid electrodes (GCE and CPE) allow to improve sensitivity and selectivity significantly, what make them a very useful tool in electrochemical analysis. Another interesting group are film electrodes (covered with bismuth, lead, antimony, mercury, gallium), 38,39 among them cyclic renewable mercury (amalgam) film electrode Hg(Ag)FE.…”

Desenvolvimento de eletrodos compósitos de carbono e poliestireno para aplicações eletroanalíticas

“…Sinais de corrente obtidas por FIA em uma ampla faixa de concentração de paracetamol (a) e dipirona (c) e apresentação de suas respectivas regiões lineares (b e d).Com o objetivo de se comparar a resposta eletroanalítica do eletrodo G-PS com outros na literatura, a Tabela 6 reúne diversos parâmetros analíticos de outros eletrodos de carbono[31,[114][115][116][117][118][119], utilizados em associação com análise em fluxo de paracetamol e de dipirona.…”