Voltammetric Techniques

Mendoza, Sandra; Bustos, Erika; Manríquez, J.; Godı́nez, Luis A.

doi:10.1002/9781118684030.ch2

Cited by 19 publications

(20 citation statements)

References 64 publications

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“…This mechanism is also applied in the nanocarbon-assisted fluorescence method of nucleic acid analysis and its interaction studies [13]. Moreover, electrochemical methods have been recently considered as rapid and reliable tools for measuring antioxidant capacity and toxicological studies in food matrices [14,15]. During the electrochemical measurement, DNA strands are immobilized on the working electrode surface and intercalating them, xenobiotic (e.g., naringin) possesses higher resistance to oxidation than DNA before interaction [16].…”

Section: Discussionmentioning

confidence: 99%

The Genoprotective Role of Naringin

et al. 2020

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Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an electrochemical biosensor. Electrochemical methods allow analyzing the damages occurring in the structure of nucleic acids and their interactions with xenobiotics. Our study showed that the changes in the location of electrochemical signals and their intensity resulted from the structural alterations in DNA. The signal of adenine was affected at lower concentrations of naringin, but the signal of guanine was unaffected in the same condition. The dynamics of changes occurring in the peak height and surface of adenine related to naringin concentration was also significantly lower. The complete binding of all adenine bases present in the tested double-stranded DNA solution was observed at naringin concentrations ranging from 8.5 to 10.0 µM. At larger concentrations, this active compound exerted an oxidizing effect on DNA. However, the critical concentrations of naringin were found to be more than twice as high as the dose absorbable in an average human (4 µM). The results of our work might be helpful in the construction of electrochemical sensors for testing the content of polyphenols and would allow determining their genoprotective functionality.

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Section: Discussionmentioning

confidence: 99%

The Genoprotective Role of Naringin

et al. 2020

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“…Literature reports that electrochemistry is a valuable approach to investigate redox processes in organic compounds, being voltammetry, the most common technique used to characterize electron transfer phenomena on working electrode surfaces [20,21]. In this sense, we employed cyclic voltammetry to gather information of all redox processes underwent by TRA in the selected electric potential interval.…”

Section: Discussionmentioning

confidence: 99%

Redox Behavior of Central-Acting Opioid Tramadol and Its Possible Role in Oxidative Stress

Contardi

Morikawa

Thomaz

2020

The 1st International E-Conference on Antioxidants in Health and Disease

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Tramadol (TRA) is a central-acting opioid whose biological activities are achieved by interaction with several bodily receptors such as μ-opioid receptors. Considering that central-acting drugs may promote oxidative stress, which could lead to neurodegeneration, this work reported the investigation of the redox behavior of TRA by electrochemical and semi-empirical quantum chemistry approaches (i.e., voltammetry and extended Hückel method—EHM) in order to study TRA pro-oxidant features. Electrochemical results showed that TRA exhibited two anodic peaks, namely: 1a at Ep1a ≈ +0.03 V and 2a at Ep2a ≈ +0.8 V; and a cathodic peak at Ep1c ≈ −0.01 V, whereas the quantum chemistry model suggested that the highest occupied molecular orbital n = 0 (HOMO-0) was associated with the tertiary amine in the TRA molecule, while HOMO-1 and the lowest unoccupied molecular orbital n = 0 (LUMO-0) were associated with the aromatic benzene ring. The findings were then used to propose an electrooxidation pathway according to the observations and compared to the literature, which further offered hints about TRA’s pro-oxidant nature. In conclusion, the work reported herein shows that voltammetric and semi-empirical quantum chemistry approaches can be correlated to investigate the redox behavior of CNS-acting compounds.

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“…Voltammetric sensing techniques include cyclic voltammetry, linear sweep/scan voltammetry, differential pulse voltammetry, square wave voltammetry, polarography, and stripping voltammetry. A two-or three-electrode electrochemical sensor containing a potentiostat can be employed to measure the current [95][96][97][98][99].…”

Section: Voltammetric Sensorsmentioning

confidence: 99%

“…The current is measured near the end of each pulse. Usually, the duration of each pulse is 1-100 ms and the interval between each pulses is 0.1-5 s [95,96]. Differential pulse voltammetry (DPV) is relatable to NPV, where the potential is also scanned with a series of pulses.…”

Section: Voltammetric Sensorsmentioning

confidence: 99%

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Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

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In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.

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Voltammetric Techniques

Cited by 19 publications

References 64 publications

The Genoprotective Role of Naringin

The Genoprotective Role of Naringin

Redox Behavior of Central-Acting Opioid Tramadol and Its Possible Role in Oxidative Stress

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

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