Voltammetric sensor for D-penicillamine determination based on its electrocatalytic oxidation at the surface of ferrocenes modified carbon paste electrodes

Abstract

Electrocatalytic oxidation of D-penicillamine (D-PA) at the surface of ferrocene modified carbon paste electrode (FCCPE) was thoroughly investigated in aqueous solution with various pH. The performance of this modified electrode was compared with those of 2,7-bis(ferrocenyl ethyl) fluoren-9-one modified carbon paste electrode (2,7-BFEFMCPE). In the optimum condition, the oxidation of D-PA at the surface of FCCPE and 2,7-BFEFMCPE is occurred about 480 and 320 mV less positive than that unmodified carbon paste electrode, respectively. The linear dynamic ranges 6 × 10 -5 M-2 × 10 -3 M, 6⋅5 × 10 -5 M-1⋅1 × 10 -3 M and 7 × 10 -6 M-1⋅6 × 10 -4 M, 7 × 10 -6 M-2 × 10 -4 M of D-PA are obtained from CV and DPV methods for FCCPE and 2,7-BFEFMCPE, respectively. The detection limits (3σ) were determined as 5⋅4 × 10 -5 M and 6⋅3 × 10 -5 M in CV and 6⋅2 × 10 -6 M and 6⋅8 × 10 -6 M in DPV determinations for FCCPE and 2,7-BFEFMCPE, respectively. The proposed method was applied in a highly sensitive determination of D-PA in drug and human synthetic serum samples by standard addition and recovery methods, respectively.

Sensitive Voltammetric Determination of Captopril Using a Carbon Paste Electrode Modified with Nano-TiO2/Ferrocene Carboxylic Acid

“…The important catalytic role of the modifier caused a lowering of the anodic overpotential. The electrochemical properties of FcCA spiked in carbon paste have been studied by cyclic voltammetry in previous works [36,37]. The electrochemical behavior of the present modified electrode was in agreement with the previous results.…”

Carbon paste electrode incorporating multi-walled carbon nanotube/ferrocene as a sensor for the electroanalytical determination of N-acetyl-L-cysteine in the presence of tryptophan

“…We have previously shown that a carbon paste electrode spiked with ferrocene is constructed by the incorporation of ferrocene in a graphite powder/paraffin oil matrix. 37 The cyclic voltammograms of FCMCPE and FCMCNPE (figure 1c and d) exhibit one anodic and cathodic peak corresponding with redox system FC/FC + , which show a quasi-reversible behaviour in an aqueous medium. The cyclic voltammograms of bare CPE and CNPE in pure supporting electrolyte show no anodic or cathodic peaks (figure 1a and b).…”

Turn-on fluorescence probe for selective and sensitive detection of d-penicillamine by CdS quantum dots in aqueous media: Application to pharmaceutical formulation

“…So far, the various analytical methods have been reported which include high performance liquid chromatography [7,8], fluorimetry [9], spectrophotometry [10], chemiluminescence [11], capillary electrophoresis [12], electrochemistry [13], voltammetry/electrochemical sensor [14][15][16] and kinetic assay [17] for the determination of d-PA in both pharmaceuticals and biomedical samples. Many of the reported methods have some own limitations, such as use of sophisticated and time consuming techniques, expensive instruments, long operation time, reagents that are mostly not available in many laboratories and low selectivity with higher interference problems.…”