Carbon paste electrode incorporating multi-walled carbon nanotube/ferrocene as a sensor for the electroanalytical determination of N-acetyl-L-cysteine in the presence of tryptophan

Abstract

The preparation and electrochemical performance of the carbon nanotube paste electrode modified with ferrocene (FCMCNPE) was investigated for electrocatalytic behaviour toward oxidation of N-acetyl-L-cysteine (NAC) in the presence of tryptophan (Trp) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed an efficient electrocatalytic activity of FCMCNPE toward oxidation of NAC and Trp, as the electrooxidation of NAC and Trp together gave two well-defined anodic peaks, revealing the applicability of this modified electrode for simultaneous voltammetric detection of mentioned compounds in the same solution. The values of catalytic rate constant (k) and the apparent diffusion coefficient (D app) were also calculated using chronoamperometry. The DPV method was applied as a sensitive method for the quantitative detection of trace amounts of NAC and Trp. A linear dynamic range from 1.0 to 18.0 μM for NAC and 2.0 to 150.0 μM for Trp was obtained using DPV method in pH 7.00 buffered solution and the detection limit (3σ) was determined as 0.49 μM and 0.54 μM for NAC and Trp, respectively. The proposed method was also applied for analysis of NAC tablet, investigating the applicability of the proposed voltammetric method for determination of NAC in real sample.

Development of a Carbon Paste Electrode Modified with Reduced Graphene Oxide and an Imidazole Derivative for Simultaneous Determination of Biological Species of N‐acetyl‐L‐cysteine, Uric Acid and Dopamine

“…From the obtained data and analytical method, the detection limit of NAC was estimated to be 61 nM ( C=3s b /m ). Some obtained analytical characteristics in this research are compared with several similar literatures in Table . The obtained results in this table indicate that the linear range is comparable with those of other reports and the detection limit obtained in this work is lower than other reports.…”

A Triple-Channel Colorimetric Sensor Array for Identification of Biothiols Based on Color RGB (Red/Green/Blue) as Signal Readout

“…In recent years, various analytical methods, including mass spectrometry, high-performance liquid chromatography, chemiluminescence, capillary electrophoresis, fluorescence, absorbance, and electrochemistry, , have been established to quantitatively detect biothiols. Each of the methods mentioned above has its own strengths; however, expensive equipment or sample pretreatments often hamper their application in medical diagnosis.…”

Electrochemical sensors based on functionalized carbon nanotubes modified with platinum nanoparticles for the detection of sulfide ions in aqueous media

“…The unique electrical, thermal, chemical, and mechanical properties of carbon nanotubes (CNTs) have made them intriguing candidates for the development of new electronic devices, chemical/electrochemical sensors and biosensors, transistors, hydrogen storage cells, supercapacitors, and lithium-ion batteries. [1][2][3][4][5] CNT-based electrodes are extremely promising for low concentration sensing applications due to their large surface area, high electrical conductivity, high strength, and exceptional electrocatalytic activity that account for the extraordinary capabilities of CNTs as high-performance electrochemical sensors. 6 Chemical vapor deposition (CVD) methods, including microwave plasma enhanced * For correspondence and thermal CVD, are the most extensively used processes for the synthesis of vertically aligned carbon nanotubes since they enable the production of larger quantities of more electrochemically reactive CNTs under easily controllable conditions and at lower costs as compared to other production techniques such as arc discharge and laser ablation.…”