Voltammetric discrimination of mandelic acid enantiomers

Zor, Erhan; Saf, Ahmet Özgür; Bingöl, Haluk; Ersöz, Mustafa

doi:10.1016/j.ab.2013.12.023

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…Further investigation of the modified electrodes was also performed by CV (Figure B). The bare GCE showed a typical reversible electrochemical response for the 5‐mM Fe(CN) 6 3−/4− redox couple at 224 mV with peak‐to‐peak potential difference (ΔE p ) of 112 mV . The GR‐modified GCE exhibited an increase in current, indicating the improved charge transfer due to the high surface area of GR nanosheets.…”

Section: Resultssupporting

confidence: 88%

“…The bare GCE showed a typical reversible electrochemical response for the 5-mM Fe(CN) 6 3−/4− redox couple at 224 mV with peak-to-peak potential difference (ΔE p ) of 112 mV. 9 The GR-modified GCE exhibited an increase in current, indicating the improved charge transfer due to the high surface area of GR nanosheets. Furthermore, by modification of GR/GCE with OPPy-BMZ shows that the OPPy acted as an insulating layer and further proves previous investigations.…”

Section: Immobilization Of Oppy-bmz Film By Electrodeposition Methodsmentioning

confidence: 98%

“…Up to now, various sensing interfaces have been developed for discrimination of mandelic acid (MA) enantiomers, including diastereomeric crystallization, high‐performance liquid chromatography, quartz crystal microbalance, fluorescence detection, and electrochemical detection . Analysis of MA, a chiral α‐hydroxy carboxylic acid, is essential, owing to its important role in natural product synthesis and drug development .…”

Section: Introductionmentioning

confidence: 99%

“…Up to now, various sensing interfaces have been developed for discrimination of mandelic acid (MA) enantiomers, including diastereomeric crystallization, 1 high-performance liquid chromatography, 2,3 quartz crystal microbalance, 4 fluorescence detection, [5][6][7][8] and electrochemical detection. 4,[9][10][11][12][13][14][15] Analysis of MA, a chiral α-hydroxy carboxylic acid, is essential, owing to its important role in natural product synthesis and drug development. 16 Using the electrochemical sensors for enantioselective sensing has several advantages over chromatographic and spectrophotometric techniques, such as simplicity, flexibility in design, ease of chemical modification, small size, low cost, rapid detection, and possibility of real-time analysis.…”

Section: Introductionmentioning

confidence: 99%

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Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Borazjani

Mehdinia

Jabbari

2017

J of Molecular Recognition

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A chiral biosensing platform was developed using betamethasone (BMZ) as chiral recognition element through multilayered electrochemical deposition of BMZ, overoxidized polypyrrole, and nanosheets of graphene (OPPy-BMZ/GR), for enantio-recognition of mandelic acid (MA) enantiomers. The deposited film was characterized by scanning electron microscopy, differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. It was shown that the chiral sensing platform can discriminate R- and S-MA differential pulse voltammetry signals, at the voltages of 1.35 and 1.33 V (vs Ag/AgCl), respectively. To tackle the problem of highly overlapping peaks of these enantiomers, the partial least squares (PLS) regression and genetic algorithm-PLS (GA-PLS) were used for simultaneous quantification of MA enantiomers. Generally, variable selection by genetic algorithm provided an improvement in prediction results when compared to full-voltammogram PLS. Good analytical performances were obtained despite the inherent complexity of the simultaneous determination.

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Section: Resultssupporting

confidence: 88%

Section: Immobilization Of Oppy-bmz Film By Electrodeposition Methodsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Borazjani

Mehdinia

Jabbari

2017

J of Molecular Recognition

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“…), the linear ranges were measured to be 0.02–5.0 mM and 0.04–10.0 mM, and the detection limits were 0.25 mM and 0.72 mM for S‐mandelic acid and R‐mandelic acid on the MIP‐Fe 3 O 4 @PNE NPs modified PDMS microchip, respectively. The results are better than those of voltammetric detection results and comparable to that of HPLC analysis . As can be seen in Fig.…”

Section: Resultssupporting

confidence: 50%

Separation of chiral compounds using magnetic molecularly imprinted polymer nanoparticles as stationary phase by microchip capillary electrochromatography

Liang

Chen

et al. 2017

Electrophoresis

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In this work, a simple and rapid approach was developed for separation and detection of chiral compounds based on a magnetic molecularly imprinted polymer modified poly(dimethylsiloxane) (PDMS) microchip coupled with electrochemical detection. Molecularly imprinted polymers were prepared employing Fe O nanoparticles (NPs) as the supporting substrate and norepinephrine as the functional monomer in the presence of template molecule in a weak alkaline solution. After extracting the embedded template molecules, Fe O @polynorepinephrine NPs (MIP-Fe O @PNE NPs) showed specific molecular recognition selectivity and high affinity towards the template molecule, which were then used as stationary phase of microchip capillary electrochromatography for chiral compounds separation. Mandelic acid and histidine enantiomers were used as model compounds to test the chiral stationary phase. By using R-mandelic acid as the template molecule, mandelic acid enantiomer was effectively separated and detected on the MIP-Fe O @PNE NPs modified PDMS microchip. Moreover, the successful separation of histidine enantiomers on the MIP-Fe O @PNE NPs modified microchip using L-histidine as template molecule was also achieved.

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Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

et al. 2021

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Chirality has become an important research subject. The research areas associated with chirality are under substantial development. Meanwhile, graphene is a rapidly growing star material and has hard‐wired into diverse disciplines. Rational combination of graphene and chirality undoubtedly creates unprecedented functional materials and may also lead to great findings. This hypothesis has been clearly justified by the sizable number of studies. Unfortunately, there has not been any previous review paper summarizing the scattered studies and advancements on this topic so far. This overview paper attempts to review the progress made in chiral materials developed from graphene and their derivatives, with the hope of providing a systemic knowledge about the construction of chiral graphenes and chiral applications thereof. Recently emerging directions, existing challenges, and future perspectives are also presented. It is hoped this paper will arouse more interest and promote further faster progress in these significant research areas.

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Voltammetric discrimination of mandelic acid enantiomers

Cited by 22 publications

References 31 publications

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Separation of chiral compounds using magnetic molecularly imprinted polymer nanoparticles as stationary phase by microchip capillary electrochromatography

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

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