Voltammetric determination of paracetamol in tablet formulation using Fe (III) doped zeolite-graphite composite modified GCE

Abstract

Although paracetamol is known to have excellent safety profile at recommended therapeutic doses, health effects are also reported at acute overdoses. A sensitive and selective voltammetric method using Fe(III) encapsulated zeolite/graphite composite modified glassy carbon electrode is presented in this work for the determination of paracetamol in tablet formulations. In contrast to the unmodified electrode, a fourfold increase of cyclic voltammetric oxidative peak current paralleled by reduced potential difference ( ΔE p ) at the modified electrode confirmed electrocatalytic property of the modifier towards oxidation of paracetamol. The oxidative peak current showed linear dependence on concentration range 0.5–200 μM with R 2 and LOD of 0.9989 and 0.01 μM, respectively. The paracetamol content of four brands of tablet samples was found in the range 95.95 ± 0.23–103 ± 0.52% of the theoretical values. Recovery results between 94.54 ± 0.82 and 102 ± 0.34% for spiked paracetamol in tablet samples validated the selectivity of the method for determination of paracetamol in real samples.

Determination of Paracetamol Based on 3‐Amino‐4H‐1,2,4‐triazole Coated Glassy Carbon Surface in Pharmaceutical Sample

“…Although there are some modified electrodes with low LOD values compared to 3AT‐GC given in Table 1 (reported in [4] and [54]), this electrode has some advantages. In general, the synthesis of coating compounds are complex.…”

“…After overdose uptake of PAR, the toxic intermediate metabolites formation especially ‘‘N‐acetyl p‐benzoquinone‐imine’’ increase [2]. This will cause some symptoms such as nervousness, headaches, nausea, insomnia, seizures, restlessness, trembling, kidney and liverdamage [3–5]. Hence, the analyse of these drugs is very important in pharmaceutical preparations.…”

The Mn‐zeolite/Graphite Modified Glassy Carbon Electrode: Fabrication, Characterization and Analytical Applications

“…To increase the performance of determination procedures some amendments were introduced. Those include the use of Cu(II)‐conducting polymer , TiO 2 ‐MWCNT , modifying of CPE with Co(II)‐exchanged zeolite A or covering the surface of GCE with Fe(III)‐Y zeolite layer .…”

Electrochemical Sensor for Detection of Paracetamol Based on Pendent Nitrogen Heterocyclic Ring‐Functionalized Polyterthiophene Derivatives

“…[1] However, either long-term use or overdose of PAR will produce side effects that give rise to symptoms such as neuroticism, insomnia, nausea, tremors, headaches, and restlessness in mild cases, and liver toxicity, kidney damage. [17][18][19] Therefore, the detection of PAR content in biological products and medicines is highly important. [20] Currently, a series of analytical methods have been developed to detect PAR, such as titrimetric, UV-vis spectrophotometry, capillary electrophoresis, high performance liquid chromatography, chemi-luminescence, and electrochemical techniques.…”