Voltammetric determination of lapachol in the presence of lapachones and in ethanolic extract of Tabebuia impetiginosa using an epoxy-graphite composite electrode

publicado na web em 07/06/2018 Natural naphthoquinones such as lapachol (Lp) have demonstrated promising biological activities. However, these quinones present low systemic biodisponibility due to its poor aqueous solubility. To overcome this problem, nanoemulsions (NE) formed by oily core are able to incorporate hydrophobic molecules thus enabling them to be dispersed into an aqueous phase. The present study reports the development, characterization, and physical stability of NE containing lapachol. NE formulations (F1, F2, F3, F4, and F2-Lp) were prepared using emulsion phase inversion (EPI) method and characterized in relation to droplet size, size distribution (PDI), zeta potential, and physical stability. The formulation chosen to incorporate lapachol (F2-Lp) showed droplet size in nanometric scale with homogeneous size distribution (PDI < 0.2) and negative zeta potential (about −30 mV). In addition, good physical stability of F2 and F2-Lp was demonstrated using analytical centrifugation with photometric detection where the light transmission profiles did not change throughout the dispersions. Nanoemulsion containing lapachol presented a strong reddish aspect; however, the incorporation of this naphthoquinone did not alter the main physicochemical parameters of NE formulation. The in vitro release study demonstrated a sustained release profile from NE with about 60% of lapachol released within 54 h.

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“…1,2 Lapachol is the most abundant quinone compound commonly isolated from the Ipe family trees (Tabebuia spp.) found in South America .…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nanoemulsion Containing a Natural Naphthoquinone

Rodrigues¹,

Diniz²,

Sousa³

et al. 2018

Quim. Nova

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“…Modification of an electrode containing various organic or inorganic compounds is a promising method for the detection process (Suherman et al, 2017). Different composite materials such as polypyrrole/bismuth oxide/graphene oxide (Verma & Jain, 2017), graphene nanosheet (Liu et al, 2012), graphene oxide/k‐carrageenan/ l ‐cysteine nanocomposite (Priya et al, 2018), graphene supported Pt nanoparticles composite (Yu et al, 2015), Cu/graphene nanocomposite (Zhu et al, 2020), CNT/pencil graphite composite (Tigari & Manjunatha, 2020), epoxy graphite composite (Almeida et al, 2017), pyrolytic graphite/single‐walled carbon nanotube (SWCNT) (Goyal et al, 2010), zeolites/MWCNT (Azab et al, 2019), and ZnFe 2 O 4 /SWCNTs (Dong et al, 2017) have been applied successfully for analyte detection using voltammetry and surfactants. Furthermore, thiabendazole (TBZ) and carbendazim (CBZ) exhibited higher electrochemical signals with CTAB compared to the absence of CTAB (Dong et al, 2017).…”

Section: Composite Materialsmentioning

confidence: 99%

Recent advances in applications of surfactant‐based voltammetric sensors

Housaindokht

Janati-Fard

Ashraf

2021

J Surfact & Detergents

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Voltammetric sensors are simple, powerful, and cheap equipment with easy principles, which have been widely used in electrochemical studies to investigate the properties of the electroactive species. Surfactants are frequently used in the construction of voltammetric sensors to enhance the sensitivity and selectivity of the sensor, which significantly impacted the electrode function in terms of dissolving organic compounds, creating a specific orientation of molecules on the surface of the electrodes, and enhancing electron transfer reactions. This review focuses on the recent contributions of surfactants in the development of efficient voltammetric sensors. In addition, other ingredients commonly employed alongside surfactants, such as nanomaterials, conducting polymers, and composite materials, have been discussed. The comprehension of these aspects can guide the expansion and the use of surfactants in the electrochemical sensing scope.

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Evaluation of Different Substrates for Electrodeposition of Riboflavin Films for Determination of Boric Acid in Eye Drops

Fernandes,

de Lima Garcia,

Araújo

et al. 2024

Smart Innovation, Systems and Technologies

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Voltammetric determination of lapachol in the presence of lapachones and in ethanolic extract of Tabebuia impetiginosa using an epoxy-graphite composite electrode

Cited by 3 publications

References 36 publications

Preparation and Characterization of Nanoemulsion Containing a Natural Naphthoquinone

Preparation and Characterization of Nanoemulsion Containing a Natural Naphthoquinone

Recent advances in applications of surfactant‐based voltammetric sensors

Evaluation of Different Substrates for Electrodeposition of Riboflavin Films for Determination of Boric Acid in Eye Drops

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