Voltammetric Determination of Ivabradine Hydrochloride Using Multiwalled Carbon Nanotubes Modified Electrode in Presence of Sodium Dodecyl Sulfate

Abstract

Purpose: A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity. Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry. Results: The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively. Conclusion: This method is suitable for determination of IH in tablets and plasma.

Molecularly-imprinted polymer-base bulk optode for the determination of ivabradine hydrochloride in Procoralan®

“…1 IVH has been approved by the European Medicines Agency in 2005 and by the United States Food and Drug Administration in 2015; it is commonly used now as anti-ischemic and antianginal at stable angina, 1 and may be administered twice daily by doses of 2.5, 5 or 7.5 mg per day. 2 Because of the problems of IVH overdose (>15 mg per day) such as blurred vision, headache, uncontrolled blood pressure and prolonged bradycardia, 1 different methods were reported for IVH quantification; these methods include spectrophotometry, 3,4 chromatography, 5–10 potentiometry, 3,11,12 and spectrofluorimetry; 13 these methods exhibited some disadvantages such as the high cost, the consumption of time and being of low selectivity.…”

Micellar‐emphasized simultaneous determination of ivabradine hydrochloride and felodipine using synchronous spectrofluorimetry

“…Different methods have been described for IVB determination including spectrofluorimetry, [ 4 ] spectrophotometry, [ 5 ] voltammetry, [ 6 ] and high‐performance liquid chromatography (HPLC). [ 7,8 ]…”

“…[2] Interestingly, it is the only agent that lowers the heart rate and avoiding adverse effects found with other bradycardic agents such as negative inotropism or effects on contractility. [3] Different methods have been described for IVB determination including spectrofluorimetry, [4] spectrophotometry, [5] voltammetry, [6] and high-performance liquid chromatography (HPLC). [7,8] Felodipine (FLD) (Figure 1b), named in full as ethylmethyl-4…”

First derivative synchronous spectrofluorimetric analysis of bisoprolol fumarate and ivabradine in pharmaceutical and biological matrices. Investigation of the method greenness

“…[ 2 ] IVA is utilized to treat stable angina and chronic heart failure. [ 2,3 ] Several analytical methods have been documented for estimating IVA, such as spectrophotometry, [ 4,5 ] spectroflourimetry, [ 6 ] voltammetry, [ 7,8 ] high‐performance liquid chromatography (HPLC), [ 9–11 ] high‐performance thin layer chromatography (HPTLC), [ 12 ] and liquid chromatography with tandem mass spectrometric detection (LC–MS/MS). [ 13 ]…”