Micellar‐emphasized simultaneous determination of ivabradine hydrochloride and felodipine using synchronous spectrofluorimetry

Abstract

A sensitive and green micellar spectrofluorimetric approach was applied for the simultaneous estimation of ivabradine hydrochloride (IVB) and felodipine (FLD) in the ng/ml concentration range. The approach depended on measuring the first derivative synchronous peak amplitude ( 1 D) of both drugs at Δλ = 60 nm in a Tween-80 micellar system. The method was rectilinear alongside the concentration ranges 0.02-0.4 μg/ml and 0.05-1.0 μg/ml at 269.5 nm and 378.5 nm for IVB and FLD, respectively.The proposed method was validated by following the International Council for Harmonization guidelines. The method was successfully applied without interference for laboratory-prepared synthetic mixtures, single pharmaceutical preparations, and within spiked biological fluids with acceptable percentage recoveries. A comparison of the performance of the suggested method with other methods, showed no discrepancy. The method's ecofriendly property evaluated using three different tools, confirming an excellent green method.

Machine Learning-Assisted Synchronous Fluorescence Sensing Approach for Rapid and Simultaneous Quantification of Thiabendazole and Fuberidazole in Red Wine

“…Synchronous fluorescence spectrometry, a technique initially described by Lloyd [16] in 1971 to map fluorescence spectra in the presence of simultaneous scanning of both excitation and emission monochromators, has been widely utilized for the investigation of mixtures. The simultaneous fluorescence approach is used by a growing number of scientists for the determination of compounds in complicated matrices, and it may be combined with other techniques, such as derivative technique, to accomplish further spectral separations [17][18][19][20][21][22]. Among these, the constant-energy synchronous fluorescence approach utilized in this work can effectively simplify the spectra, narrow the spectral band, and eliminate the influence of scattered light by selecting an appropriate constant-energy difference, making it advantageous for the detection of mixtures.…”