Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuO_x Decorated MW‐CNT Modified Glassy Carbon Electrode

Abstract

Copper oxide decorated multi‐walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) was prepared for determination of isoniazid (INZ) in various matrices. The electrochemical behavior of INZ was tested with the aid of Cyclic Voltammetry (CV) and quantitative experiments were performed by using Linear Sweep Voltammetry (LSV). Morphological and structural characterization of the modified electrode was performed by utilizing Scanning Electron Microscopy (SEM), X‐Ray Photoelectron Spectroscopy (XPS) while electrochemical characterization was performed by using CV and Electrochemical Impedance spectroscopy (EIS). The proposed sensor exhibited well defined anodic peak at 0.30 V for INZ at pH 6.0 medium. Under the optimum conditions, a linear relation between INZ concentration and peak current was observed in the range of 2.0×10−7 to 5.0×10−5 M. Limit of detection was calculated as 1.0×10−8 M and repeatability and accuracy was found as 5.60 % and 91.0 % for 5.0 10−7 M INZ by using 3 successive measurement, respectively. Then, the analytic performance of the electrode developed was tested by analyzing commercial tablets, artificial human serum and urine samples. The results indicated that satisfactory recoveries was observed for all issue.

A highly sensitive and ecofriendly assay platform for the simultaneous electrochemical determination of rifampicin and isoniazid in human serum and pharmaceutical formulations

“…Hence, a number of electrochemical methods using hanging mercury drop electrode, gold, carbon paste, glassy carbon, or pencil graphite electrodes have been used for INZ and RIF analyses. 23–31…”

Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

“…This disadvantage of the bare electrode has made the use of modified electrodes mandatory. In addition, electrode modification offers many more advantages such as lowering the over-potential, increasing the reaction rate and improving the sensitivity (Lou et al, 2020;Özdokur, 2020;Saleh et al, 2016).…”

Validation Study of a Spectrophotometric Binary Micture Analysis

“…Analytical methods such as spectrophotometry [4], mass-spectrometry [5], chromatography [6] and electrophoresis [7], electrochemistry [8] and their joint devices have been used for analytical purposes. Mainly, LC and CE methods have been used in conjunction with different spectroscopic systems (separate techniques, namely LC-MS and CE-MS) to obtain more chemical data and reduce the complication of multicomponent substance analysis.…”