Voltammetric determination of analgesics using a montmorillonite modified electrode

Muralidharan, B.; Gopalakrishnan, Gayathri; Vedhi, C.; Manisankar, P.

doi:10.1016/j.clay.2007.11.005

Cited by 41 publications

(14 citation statements)

References 38 publications

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“…Thus, it is necessary to develop methods of their determination in human body fluids. Last years, applications of electrochemical methods in determination and studies of drugs attract a lot of attention because of their accuracy and simplicity [9][10][11][12][13][14][15][16][17]. Electrochemical measurements enable determination of various physicochemical parameters of tested compounds, e.g.…”

Section: Introductionmentioning

confidence: 99%

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Wudarska¹,

Chrześcijańska²,

Kuśmierek³

2014

Port. Electrochim. Acta

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Electroreduction properties of salicylic (SA) and acetylsalicylic (ASA) acids were investigated at platinum electrode using the voltammetry method. Cyclic voltammograms (CV) of the tested compounds were used in determining half-wave potential (E 1/2 ) -the parameter describing the anti-reductive properties. The content of active substances (SA and ASA) in the selected pharmaceuticals (salicylic alcohol, Bayer aspirin, etopirin and polopirin) was examined with the application of electrochemical and spectrophotometric methods.

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Section: Introductionmentioning

confidence: 99%

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Wudarska¹,

Chrześcijańska²,

Kuśmierek³

2014

Port. Electrochim. Acta

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“…Because montmorillonite has high chemical and mechanical stability, a well-layered structure and strong adsorptive properties attributed to the expandability of the internal layers, it has been successfully used in electroanalytical chemistry as a modifier in carbon electrodes for assay of different organic [5][6][7] and inorganic [8][9][10][11][12] species.…”

Section: Introductionmentioning

confidence: 99%

Utilization of a montmorillonite-Ca-modified carbon paste electrode for the stripping voltammetric determination of diflunisal in its pharmaceutical formulations and human blood

Beltagi

2009

J Appl Electrochem

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A highly sensitive square-wave adsorptive anodic stripping voltammetric method was described for the determination of diflunisal in its formulations and human blood, utilizing a developed montmorillonite-Camodified carbon paste electrode (CPE). The peak current was significantly enhanced due to the strong adsorptive properties of montmorillonite-Ca clay. The optimal procedural parameters were frequency f = 80 Hz, scan increment DE a = 10 mV, pulse-amplitude DE i = 25 mV, and an accumulation potential E acc of 0.0 V versus Ag/ AgCl/3M KCl in acetate buffer of pH 5.0 using 10% (w/w) MMT-Ca-modified CPE. The described method was successfully applied for assay of diflunisal in different pharmaceutical formulations (Doloban Ò , Dolozal Ò , and Maxipan Ò tablets) with mean percentage recoveries of 98.72 ± 0.35, 99.24 ± 0.89, and 98.20 ± 1.38, respectively. Furthermore, the method was successfully applied for assay of diflunisal in spiked human serum without the necessity of sample pretreatment or time-consuming extraction prior to the analysis. Mean percentage recovery of diflunisal in human serum was 99.16 ± 1.03 with a limit of detection of 3.0 9 10 -9 M (0.75 ng mL -1 ). Due to this extremely low limit of detection, the proposed method was used to follow up the concentration of drug in blood samples of two male volunteers after oral administration of a single dose of Dolozal Ò , 500 mg tablet.

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“…Researchers have employed polymeric film modified electrodes to detect organic and inorganic molecules in recent years. Electrochemical methods, such as differential pulse polarography (DPP), stripping voltammetry (SV), differential pulse voltammetry (DPV) and square-wave voltammetry (SWV) have been widely applied for the determination of pharmaceuticals [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. In the present investigation, a simple, effective and sensitive electrochemical method for the determination of ibuprofen on polyaniline nanofiber modified electrodes is explored.…”

Section: Introductionmentioning

confidence: 99%

Electroanalysis of Ibuprofen on Conducting Polyaniline Nanofiber Coated Glassy Carbon Surface

Suresh

Sundaram

Kavitha³

et al. 2016

Int J Curr Pharm Sci

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Objective: Voltammetric procedure for analysis of pharmaceutical formulation of ibuprofen on conducting polyaniline nanofiber modified glassy carbon electrode was explored. Methods:The effect of pH was studied at different medium such as acidic, neutral and basic. The cyclic voltammetric behavior of ibuprofen was studied between−0.5 V and 1.8 V versus Ag/AgCl at modified glassy carbon surface. Results:The electroanalytical parameters of the detection are highly dependent on their configuration and dimensions of the electrode. The scan rate and concentration effect of ibuprofen were studied. The best limit of detection was 100 ppb and the linear range from 200 to 400 ppb on the modified electrode surface. The determination was successfully applied for the detection of drugs in several pharmaceutical drug formulations. The Atomic force microscopic (AFM) image shows the surface morphologies of polymer modified surface; compound adsorbed surface, particle distribution graphs and surface roughness values, which are in good agreement. Conclusion:The anodic peak was observed at 1.63 V, assigned for the oxidation of ibuprofen, which is not accompanied by corresponding cathodic reduction. This behavior suggested that the irreversibility of the electrode process.

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Voltammetric determination of analgesics using a montmorillonite modified electrode

Cited by 41 publications

References 38 publications

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Utilization of a montmorillonite-Ca-modified carbon paste electrode for the stripping voltammetric determination of diflunisal in its pharmaceutical formulations and human blood

Electroanalysis of Ibuprofen on Conducting Polyaniline Nanofiber Coated Glassy Carbon Surface

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