Voltammetric and spectroscopic studies on binding of antitumor Morin, Morin–Cu complex and Morin–β-cyclodextrin with DNA

Temerk, Y. M.; Ibrahim, Mohamed; Kotb, Mamdouh Ali

doi:10.1016/j.saa.2008.07.001

Cited by 35 publications

(17 citation statements)

References 22 publications

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“…The average daily intake of total flavonoids in the U.S. diet is estimated to be 0.2−1 g. 1,2) Flavonoids have recently been the focus of much attention owing to their antiproliferative effect on various cancer cells, as well as their antioxidative potential. 3) Morin (3,5,7,2′,4′-pentahydroxyflavone) is one of the flavonoids found in fruits, vegetables, tea, and a number of Asian medicinal herbs. 4) It has been reported to possess antiinflammatory, anti-cancer, anti-oxidant, anti-hypertensive, and anti-clastogenic activities.…”

Section: Enhanced Oral Bioavailability Of Morin Administered In Mixedmentioning

confidence: 99%

Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

Choi

Yoon

Choi

et al. 2015

Biological & Pharmaceutical Bulletin

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To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, size distribution, drug encapsulation efficiency, and percent drug loading of the formulation were characterized. Subsequently, in vivo pharmacokinetic parameters of morin loaded in a PluronicF127 and Tween80 mixed-micelle formulation were investigated in rats. Absolute bioavailability of morin was dramatically increased by the oral administration of morin-loaded PluronicF127 and Tween80 mixed micelle from 0.4% to 11.2% without changing the systemic clearance and half-life. In Caco-2 cells, absorption permeability of morin from the novel formulation was increased 3.6-fold compared with that of morin alone. P-gp inhibition by cyclosporine A (CsA) increased absorptive permeability of morin 2.4-fold but decreased the efflux of morin by 52%, which was consistent with increased plasma concentration of morin in the pretreatment of CsA in rats. The morin formulation inhibited P-gp transport activity by 83.1% at 100 µM as morin concentration. Moreover, morin formulation increased paracellular permeability of Lucifer yellow by 1.6-1.8 fold. In conclusion, enhanced oral bioavailability of morin from morin-loaded PluronicF127 and Tween80 mixed micelle formulation can be attributed to increased intestinal permeation of morin, which was mediated at least by P-gp inhibition and enhanced paracellular route.

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Section: Enhanced Oral Bioavailability Of Morin Administered In Mixedmentioning

confidence: 99%

Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

Choi

Yoon

Choi

et al. 2015

Biological & Pharmaceutical Bulletin

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“…Drug-DNA interactions have been studied by different techniques such as luminescence [3], UV-visible spectroscopy [4][5][6][7][8], fluorescence spectroscopy [9,10], fourier transform infrared spectroscopy (FTIR) [11,12], nuclear magnetic resonance (NMR) [13] and electrochemical methods [14][15][16][17][18][19]. Electrochemical methods have witnessed wide applications that can be applied not only for fundamental studies but also in the practical applications due to their high selectivity, rapidness and low cost instrumentation [20].…”

Section: Introductionmentioning

confidence: 99%

Interactions of an anticancer drug lomustine with single and double stranded DNA at physiological conditions analyzed by electrochemical and spectroscopic methods

Temerk

Ibrahim

et al. 2016

Journal of Electroanalytical Chemistry

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“…A systematic comparative study of the binding of antitumor morin, morin--CD, and morin-Cu complexes with DNA has been investigated in the Britton-Robison (BR) buffer solutions using voltammetric and spectroscopic methods [70]. The results showed that morin molecule, acting as an intercalator, was inserted into the cavity of the -cyclodextrin ( -CD) as well as into the base stacking domain of the DNA double helix.…”

Section: Electrochemicalmentioning

confidence: 99%

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Radi¹

2010

TOCBMJ

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Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal electrodes and nanoparticles, and cyclodextrin-modified multiwalled carbon nanotubes are also discussed.

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Voltammetric and spectroscopic studies on binding of antitumor Morin, Morin–Cu complex and Morin–β-cyclodextrin with DNA

Cited by 35 publications

References 22 publications

Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

Interactions of an anticancer drug lomustine with single and double stranded DNA at physiological conditions analyzed by electrochemical and spectroscopic methods

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

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