Voltammetric analysis of naringenin at a disposable pencil graphite electrode – application to polyphenol content determination in citrus juice

David, Iulia Gabriela; Liţescu, Simona Carmen; Popa, Dana Elena; Buleandră, Mihaela; Iordache, Lorelei; Albu, Camelia; Alecu, Andreia; Penu, Ramona

doi:10.1039/c8ay02281j

Cited by 22 publications

(23 citation statements)

References 37 publications

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“…Naringin as compounds has three aromatic rings, which provide two electrochemical signals. The lower number of registered peaks is an effect of the delocalization of electron charge between two adjacent naringin rings [17].…”

Section: Discussionmentioning

confidence: 99%

The Genoprotective Role of Naringin

et al. 2020

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Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an electrochemical biosensor. Electrochemical methods allow analyzing the damages occurring in the structure of nucleic acids and their interactions with xenobiotics. Our study showed that the changes in the location of electrochemical signals and their intensity resulted from the structural alterations in DNA. The signal of adenine was affected at lower concentrations of naringin, but the signal of guanine was unaffected in the same condition. The dynamics of changes occurring in the peak height and surface of adenine related to naringin concentration was also significantly lower. The complete binding of all adenine bases present in the tested double-stranded DNA solution was observed at naringin concentrations ranging from 8.5 to 10.0 µM. At larger concentrations, this active compound exerted an oxidizing effect on DNA. However, the critical concentrations of naringin were found to be more than twice as high as the dose absorbable in an average human (4 µM). The results of our work might be helpful in the construction of electrochemical sensors for testing the content of polyphenols and would allow determining their genoprotective functionality.

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Section: Discussionmentioning

confidence: 99%

The Genoprotective Role of Naringin

et al. 2020

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“…Hence repeatability of this work is not favored as many significant details of the experiment were not substantiated. Another sensor reported was PGE* , had relatively larger sensing surface area (5 mm diameter and length of 1 cm) compared to other standard electrodes utilized as sensing regimes. Moreover PGE* required potentiodymanic activation of ten cycles sweeping between large potential window of −500 and 2000 mV for enhanced sensitivity towards NR.…”

Section: Resultsmentioning

confidence: 98%

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

Manasa¹,

Mascarenhas²,

Bhakta

et al. 2019

Electroanalysis

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Naringenin (NR) displays strong antioxidant and numerous pharmacological activities, mitigating severity of metabolic‐syndromes without undesirable side‐effects. With the upsurge of interest in administering NR as diet‐supplement antioxidant, in this work for the first time we implemented functionalized‐MWCNT/Nileblue‐composite on carbon paste electrode (fMWNCT/NB/MCPE), as electrochemical sensor for catalytic NR oxidation. Integrated properties of fMWCNT/NB and their consonance with CPE, led to lowering of Rct value with fast‐kinetics and diminution of over‐potential. NR determination was due to electrical‐conductivity, π‐π and electrostatic‐forces that magnified anodic current by 5.5 fold. In the pH range 3.0 to 10.0 NR undergoes irreversible oxidation via transfer of 1e−/H+. Critical parameters, namely, pH and scan rate were assessed to reinforce differential pulse voltammtery (DPV) sensitivity for quantitative measurements. Sensor's selectivity, stability, accuracy and reproducibility were determined. Finally its viability in quantifying NR was validated by scrutinizing NR fortified fruit juices, as real sample matrices.

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“…Pt (0.57) < GCE (0.75) < PGE (3.06), suggest that the higher signal recorded at the PGE can be also attributed to the irregular morphology of the PGE surface, which can result in enhancement of the electrode electroactive surface area [45]. There are also various types of graphite pencil leads characterized by different hardness grades depending on their clay and graphite content and having, therefore, different properties; according to the European Letter Scale harder graphite pencil leads (noted with H) have higher clay content, whereas the softer ones (noted with B, derived from blackness) are characterized by higher graphite content [45,46]. The DPV oxidation signal of DIP was investigated using graphite pencil leads of different hardness degrees (from 2H to 2B).…”

Section: The Influence Of the Working Electrodementioning

confidence: 99%

Novel voltammetric investigation of dipyridamole at a disposable pencil graphiteelectrode

David¹,

Iordache²,

Popa³

et al. 2019

Turk J Chem

Self Cite

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The present paper describes the voltammetric analysis of dipyridamole (DIP) at a cheap, disposable pencil graphite electrode (PGE). The working conditions were optimized with regard to the electrode material and the supporting electrolyte. Cyclic voltammetric investigations emphasized that DIP is irreversibly oxidized at the PGE. The electrode process is pH-dependent and controlled by both diffusion and adsorption. For DIP quantitative determination a differential pulse voltammetric (DPV) method in phosphate buffer solution pH 7.00 was developed. DIP's oxidation peak current varied linearly with the analyte concentration, presenting two linear ranges, namely 5.00 × 10 −7-2.50 × 10 −5 M and 2.50 × 10 −5-2.50 × 10 −4 M, with detection and quantification limits of 1.21 × 10 −7 M and 4.03 × 10 −7 M DIP, respectively. The newly developed DPV method using the inexpensive, disposable PGE was successfully applied for the simple and rapid determination of DIP from pharmaceutical formulations.

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Voltammetric analysis of naringenin at a disposable pencil graphite electrode – application to polyphenol content determination in citrus juice

Abstract: The electrochemical behaviour of the flavonoid naringenin (NGN) was investigated for the first time by cyclic voltammetry (CV), using a disposable electroactivated pencil graphite electrode (PGE*).

Cited by 22 publications

References 37 publications

The Genoprotective Role of Naringin

The Genoprotective Role of Naringin

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

Novel voltammetric investigation of dipyridamole at a disposable pencil graphiteelectrode

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