Volatile organic compound patterns predict fungal trophic mode and lifestyle

Guo, Yongbo; Jud, Werner; Weikl, Fabian; Ghirardo, Andrea; Junker, Robert R.; Polle, Andrea; Benz, J. Philipp; Pritsch, Karin; Schnitzler, Jörg‐Peter; Rosenkranz, Maaria

doi:10.1038/s42003-021-02198-8

Cited by 49 publications

(40 citation statements)

References 93 publications

(122 reference statements)

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“…Nine new phenalenone derivatives, aspergillussanone D (192), aspergillussanone E (193), F (194) G ( 195) H (196), I (197), J (198), K (199), along with two known analogues, the aspergillussanones L (200 The compound terrein (202, Figure 12), a polyketide, was extracted from Aspergillus terreus JAS-2 associated with Achyranthus aspera. Terrein (202) exhibited antibacterial activity with an IC 50 value of 20 µg/mL against E. faecalis, and more than 20 µg/mL against Aeromonas hydrophila and S. aureus, as the compound showed only 48% and 38.3% inhibition [100].…”

Section: Aspergillusmentioning

confidence: 99%

“…Several reviews have emphasized the production of biogenic VOCs as possible signal molecules in the course of interaction with a host or that play a role in the process of host integration. At times they are also identified as indicators of fungal growth [196][197][198]. Fungal VOCs largely comprise aliphatic as well as aromatic hydrocarbons, aldehydes, mono-, di-and sesquiterpenes, esters and ketones.…”

Section: Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

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Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Aspergillusmentioning

confidence: 99%

Section: Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…Fungi are able to produce and use numerous volatile organic compounds (VOCs), including VPs [ 50 , 51 ]. In the investigated control culture with 20% water (instead of landfill leachate) for 48 h, a decrease in VP formation was noticed.…”

Section: Resultsmentioning

confidence: 99%

Ecotoxicological Estimation of 4-Cumylphenol, 4-t-Octylphenol, Nonylphenol, and Volatile Leachate Phenol Degradation by the Microscopic Fungus Umbelopsis isabellina Using a Battery of Biotests

Janicki

Długoński

Felczak

et al. 2022

IJERPH

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The phenolic xenobiotics nonylphenol (NP), 4-tert-octylphenol (4-t-OP), and 4-cumylphenol (4-CP) have the potential to seriously disrupt the endocrine system. Volatile phenols (VPs), especially those present in landfill leachate, also adversely affect the health of numerous organisms. Microbial degradation of xenobiotics can result in the formation of intermediates with higher toxicity than the precursor substrates. Therefore, the main aim of this study was to assess the changes in environmental ecotoxicity during the biotransformation of nonylphenol, 4-tert-octylphenol, 4-cumylphenol and volatile phenols by Umbelopsis isabellina using a battery of biotests. The application of bioindicators belonging to different taxonomic groups and diverse trophic levels (producers, consumers, and reducers) indicated a significant reduction in toxicity during the cultivation of fungus cultures both for nonylphenol, 4-tert-octylphenol, 4-cumylphenol and volatile phenols. The rate of toxicity decline was correlated with the degree of xenobiotic biotransformation. Removal of 4-cumylphenol and 4-tert-octylphenol also led to a decrease in the anti-androgenic potential. Moreover, this is the first report demonstrating the anti-androgenic properties of 4-cumylphenol. The results showed that U. isabellina is an attractive tool for the bioremediation and detoxification of contaminated environments.

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“…Diversity of chemical mixtures have been quantified for e.g. fungi VOCs (Guo et al ., 2021), snake venom (Holding et al ., 2021), coralline algae metabolites (Jorissen, 2021) and fish fatty acids (Feiner et al ., 2018). Instead of using traditional measures, such studies can also include the structural dissimilarities of compounds for more comprehensive measures of chemodiversity.…”

Section: Resultsmentioning

confidence: 99%

Quantifying chemodiversity considering biochemical and structural properties of compounds with the R packagechemodiv

Petrén

Köllner

Junker

2022

Preprint

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SummaryPlants produce large numbers of phytochemical compounds affecting plant physiology and interactions with their biotic and abiotic environment. Recently, chemodiversity has attracted considerable attention as an ecologically and evolutionary meaningful way to characterize the phenotype of a mixture of phytochemical compounds.Currently used measures of phytochemical diversity, and related measures of phytochemical dissimilarity, generally do not take structural or biosynthetic properties of compounds into account. Such properties can be indicative of the compounds’ function and inform about their biosynthetic (in)dependence, and should therefore be included in calculations of these measures.We introduce the R package chemodiv, which retrieves biochemical and structural properties of compounds from databases and provides functions for calculating and visualizing chemical diversity and dissimilarity for phytochemicals and other types of compounds. Our package enables calculations of diversity that takes the richness, relative abundance and – most importantly – structural and/or biosynthetic dissimilarity of compounds into account. We illustrate the use of the package with examples on simulated and real datasets.By providing the R package chemodiv for quantifying multiple aspects of chemodiversity, we hope to facilitate investigations of how chemodiversity varies across levels of biological organization, and its importance for the ecology and evolution of plants and other organisms.

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Volatile organic compound patterns predict fungal trophic mode and lifestyle

Cited by 49 publications

References 93 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Ecotoxicological Estimation of 4-Cumylphenol, 4-t-Octylphenol, Nonylphenol, and Volatile Leachate Phenol Degradation by the Microscopic Fungus Umbelopsis isabellina Using a Battery of Biotests

Quantifying chemodiversity considering biochemical and structural properties of compounds with the R packagechemodiv

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