Volatile and Phenolic Components and Antioxidant, Acetylcholinesterase, Tyrosinase, α-Glucosidase Inhibitory Effects of Extracts Obtained From <i>Campanula latifolia</i> L. subsp. <i>latifolia</i>

Korkmaz, Büşra; Fandaklı, Seda; Barut, Burak; Yıldırım, Sercan; Şener, Sila; Öztürk, Elif; Terzioğlu, Salih; Yaylı, Nurettin

doi:10.1080/0972060x.2020.1856004

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…However, only 30% of phenolic compounds were identified in the leaf extract of this bellflower ( Table 1 ), but the data in the literature indicate that the major compounds in Campanula leaves are luteolin derivatives, which may be used as chemotaxonomic markers [ 51 ]. The antioxidant activity of other Campanula species has been described in the literature [ 49 , 50 ], and was generally lower than presented here. The IC 50 value of DPPH radical-scavenging activity of the methanolic extract of C. latifolia susp.…”

Section: Discussioncontrasting

confidence: 41%

“…Aerial parts of C. hercegovina contained significant amounts of rutin and pinocembrin, as well as chlorogenic acid ( Table 1 ), which are also found in other species of Campanula genus [ 49 , 50 ]. However, only 30% of phenolic compounds were identified in the leaf extract of this bellflower ( Table 1 ), but the data in the literature indicate that the major compounds in Campanula leaves are luteolin derivatives, which may be used as chemotaxonomic markers [ 51 ].…”

Section: Discussionmentioning

confidence: 95%

“…The IC 50 value of DPPH radical-scavenging activity of the methanolic extract of C. latifolia susp. latifolia was 410.67 ± 2.49 μg/mL [ 49 ], while the methanolic extract of C. macrostachya reached an IC 50 value of 4150 μg/mL [ 50 ]. In addition, Alhage et al [ 52 ] showed that the leaf and flower extracts of C. retrorsa were active against C. albicans , while the extracts of C. glomerata and C. olympica were potent against K. pneumonias [ 53 ] but were inefficient against E. coli and S. aureus .…”

Section: Discussionmentioning

confidence: 99%

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Exploring New Sources of Bioactive Phenolic Compounds from Western Balkan Mountains

Karalija

Dahija

Demir

et al. 2022

Plants

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This study presents the first report on phenolic composition and bioactivity of ethanolic extracts of three plant species that grow in the western Balkan mountains and are used in traditional folk medicine: Valeriana montana, Salix retusa, and Campanula hercegovina. Phenolics were extracted from different aerial plant parts using 80% ethanol to assess the possibility of sustainable use of these plants as a source of bioactive compounds without disruption to the roots (for V. montana) or destruction of whole habitats (for S. retusa and C. hercegovina). The ethanolic extract of V. montana flower contained noticeable levels of apigenin and quercetin. The branches and bark of S. retusa were significantly rich in catechin, while rutin was the major phenolic found in the leaf extract of C. hercegovina. Furthermore, the flower extract of V. montana revealed the best antioxidant activity, which was comparable to 4-hydroxybenzoic acid and quercetin. Considering antimicrobial activity, the leaf extracts of V. montana and C. hercegovina demonstrated potent activity against all microbes tested, while the extracts of S. retusa were moderately effective. The presented results emphasize the potential of these plants as novel sources of bioactive compounds.

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Section: Discussioncontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Exploring New Sources of Bioactive Phenolic Compounds from Western Balkan Mountains

Karalija

Dahija

Demir

et al. 2022

Plants

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“…Similar results were also reported by Korkmaz et al (2020) for the antioxidant effect of C. latifolia. [42] Alhage et al (2018) reported that the radical scavenging ability of the aqueous extract of C. retrorsa was quite high (> 90 %). [43] Taşkın and Bitis (2016) tested the metal chelating abilities of various wild edible plants, including Campanula lyrata.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Yilmaz,

Cakir,

Izol

et al. 2023

Chemistry & Biodiversity

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The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional‐modern life, promotes the creation of new value‐added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC‐MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC‐MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial‐MeOH extract), fumaric acid (6.3 mg/g aerial‐H2O extract, 2.5 mg/g root‐ H2O extract), protocatechuic acid (11.4 mg/g aerial‐H2O extract), vanilic acid (1.4 mg/g aerial‐EtOH extract), quercetin‐3‐O‐rutinoside (rutin) (2.3 mg/g aerial‐EtOH extract), hesperetin 7‐rutinoside (hesperidin) (2.0 mg/g aerial‐EtOH extract), kaempferol‐3‐O‐rutinoside (nicotiflorin) (5.5 mg/g aerial‐EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial‐H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.

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“…Numerous studies have proved that some of these have antioxidant, enzyme inhibitory, antimicrobial activities, antiinflammatory and wound-healing potential. [8][9][10][11] The topicality of this research is based on the fact that, as a reading of relevant literature informs, limited research has been done into this and adjacent species of bellflower growing in the Azerbaijani flora. Among unstudied species belonging to the Medium D.C. section of this genus, C. saxifraga subsp.…”

Section: Introductionmentioning

confidence: 99%

Histo-Anatomical Study of Campanula saxifraga subsp. meyeriana (Rupr.) Ogan

Mubariz¹,

Isa²,

Kochari³

et al. 2022

Pharmacogn. Res.

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Background: Representatives of the Campanulaceae family are widespread in Azerbaijan. These plants are rich in biologically active compounds such as flavonoids, essential oils, saponins, coumarins, etc. Objectives: This work presents histo-anatomical research on crosssections of the root, stem, leaf and petal of Campanula saxifraga subsp. meyeriana (Rupr.) Ogan. Materials and Methods: Endemic in the Caucasus, these sub-species inhabit the subalpine zone. The plant grows on horizontal rock crevices in the village of Gryz, the Guba region of Azerbaijan. Blocks were prepared according to the generally accepted methods in electron microscopy. Results: The microscopic examination of the cross-section of the stem revealed that the cortex is composed of 8-10 layers of collenchyma and laticifers are seen between the endoderm layer and the phloem. The conductive tissue is in two coextensive rings on the cross-section of the root, and laticifers are detected in the cortex. The leaf has a bifacial structure. On the cross-section of the petal, the mesophilic layer is poorly developed. Conclusion:The microscopic examination provides a basis to determine the identity of C. saxifraga subsp. meyeriana (Rupr.) Ogan.

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Volatile and Phenolic Components and Antioxidant, Acetylcholinesterase, Tyrosinase, α-Glucosidase Inhibitory Effects of Extracts Obtained From Campanula latifolia L. subsp. latifolia

Cited by 6 publications

References 38 publications

Exploring New Sources of Bioactive Phenolic Compounds from Western Balkan Mountains

Exploring New Sources of Bioactive Phenolic Compounds from Western Balkan Mountains

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Histo-Anatomical Study of Campanula saxifraga subsp. meyeriana (Rupr.) Ogan

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