The present study aims at exploring the stress evolution and potential crack initiation sites on the void surface embedded in nickel‐based single crystal super alloy during uniaxial tensile creep. To this aim, the crystallographic creep constitution relationship was incorporated into three dimensional finite element simulations. The simulation results showed that the stress distribution and evolution on the void surface exhibits strong dependence upon creep time and crystallographic orientation. The potential nucleation sites of creep crack on the void surface associated with differently orientated single crystals were predicted.