Void filling of tibia compression fracture zones using a novel resorbable nanocrystalline hydroxyapatite paste in combination with a hydroxyapatite ceramic core: first clinical results

Huber, F.-X.; McArthur, Nicholas; Hillmeier, J.; Kock, Hans Jürgen; Baier, Martin; Diwo, Martin; Berger, Irina; Meeder, P. J.

doi:10.1007/s00402-006-0170-1

Cited by 49 publications

(26 citation statements)

References 28 publications

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“…On the other hand, a >10% increase of nHA reduces the mechanical properties due to a marked clustering effect of nano-particles [5]. The chemical formula of HA is Ca 10 (PO 4 ) 6 (OH) 2 and it is known as pentacalcium hydroxide tris (orthophosphate) [6][7][8]. In the last twenty years, enormous attention has been given to the HA-based filler reinforcement for polymer matrices for plausible biomedical applications such as tissue engineering [9].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE) incorporated with nano-hydroxyapaptite nanorods (mPE-nHA) was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscopy (AFM) and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT) was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT) by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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“…This ready-to-use injectable paste received CE (Conformite Europeenne) approval in 2002. Ostim® is a suspension of synthetic nanocrystalline HA (average crystal dimensions: 100 × 20 × 3 nm3 (a needle-like appearance); specific surface area ~ 100 m2/g) in water, prepared by a wet chemical reaction [610]. After completion, the HA content in the paste is ~ 35%.…”

Section: Bone Repairmentioning

confidence: 99%

“…Ostim® can be used in metaphyseal fractures and cysts, alveolar ridge augmentation, acetabulum reconstruction and periprosthetic fractures during hip prosthesis exchange operations, osteotomies, filling cages in spinal column surgery, etc. [609][610][611][612][613][614][615][616][617][618][619][620][621][622]. It might be incorporated into bones and a new bone formation is visible after only three months [623].…”

Section: Bone Repairmentioning

confidence: 99%

“…For a number of clinical applications, Ostim® might be combined with other types of calcium orthophosphate bioceramics, e.g., with a HA bioceramic core (Cerabone®) [610,624] or with biphasic (β-TCP + HA) granules (BoneSaves®) [625]. Application of such combinations of a nanocrystalline Ostim® with the microcrystalline calcium orthophosphate bioceramics appeared to be an effective method for treatment of both tibia head compression fractures [610] and metaphyseal osseous volume defects in the metaphyseal spongiosa [624]. Besides, such combinations might be used for acetabular bone impaction grafting procedures [625].…”

Section: Bone Repairmentioning

confidence: 99%

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Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…31 A further series by the same group showed similarly encouraging results when it was used to treat metaphyseal defects in fractures of the tibial plateau. 32 Nanocomposite scaffolds composed of type I collagen and nanostructured HA are currently being used in the treatment of osteochondral defects of the knee. Kon et al 33 have shown encouraging short-term clinical and radiological results with a nanocomposite biological implant for the treatment of focal osteochondral lesions.…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Nanotechnology

Sullivan

McHale

Parvızı

et al. 2014

The Bone & Joint Journal

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Nanotechnology is the study, production and controlled manipulation of materials with a grain size < 100 nm. At this level, the laws of classical mechanics fall away and those of quantum mechanics take over, resulting in unique behaviour of matter in terms of melting point, conductivity and reactivity. Additionally, and likely more significant, as grain size decreases, the ratio of surface area to volume drastically increases, allowing for greater interaction between implants and the surrounding cellular environment. This favourable increase in surface area plays an important role in mesenchymal cell differentiation and ultimately bone–implant interactions. Basic science and translational research have revealed important potential applications for nanotechnology in orthopaedic surgery, particularly with regard to improving the interaction between implants and host bone. Nanophase materials more closely match the architecture of native trabecular bone, thereby greatly improving the osseo-integration of orthopaedic implants. Nanophase-coated prostheses can also reduce bacterial adhesion more than conventionally surfaced prostheses. Nanophase selenium has shown great promise when used for tumour reconstructions, as has nanophase silver in the management of traumatic wounds. Nanophase silver may significantly improve healing of peripheral nerve injuries, and nanophase gold has powerful anti-inflammatory effects on tendon inflammation. Considerable advances must be made in our understanding of the potential health risks of production, implantation and wear patterns of nanophase devices before they are approved for clinical use. Their potential, however, is considerable, and is likely to benefit us all in the future. Cite this article: Bone Joint J 2014; 96-B: 569–73.

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Void filling of tibia compression fracture zones using a novel resorbable nanocrystalline hydroxyapatite paste in combination with a hydroxyapatite ceramic core: first clinical results

Abstract: The use of the Ostim and Cerabone combination is an effective method in treating tibia compression fractures with large defect zones left after reduction.

Cited by 49 publications

References 28 publications

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanotechnology

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