Voice Formants in Individuals With Congenital, Isolated, Lifetime Growth Hormone Deficiency

Valença, Eugênia H O; Salvatori, Roberto; Souza, Anita H. O.; Oliveira-Neto, Luiz A.; Oliveira, Alaíde H.A.; Gonçalves, Maria Inês Rebelo; Oliveira, Carla R. P.; D’Ávila, Jeferson Sampaio; Melo, Valdinaldo Aragão de; Carvalho, Susana de; Andrade, Bruna Mateus Rocha de; Nascimento, Larisse Silva; Rocha, Savinny B. de V.; Ribeiro, Thaís Regina Silva; Prado-Barreto, Valéria Maria; Melo, Enaldo Vieira de; Aguiar‐Oliveira, Manuel H.

doi:10.1016/j.jvoice.2015.03.015

Cited by 20 publications

(8 citation statements)

References 17 publications

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“…Formal voice analysis showed higher values of most formant frequencies, suggesting smaller oral and pharyngeal cavities. The voice changes result in a reduction of the effect of gender on the structure of the formants, maintaining a pre-pubertal acoustic prediction (64). Therefore, GH plays a relevant role in the development of voice quality, mostly increasing vocal cords thickness (62,63,64).…”

Section: Bone Growth and Structurementioning

confidence: 99%

“…These features have been published in 42 different publications (2,19,22,25,27,29,30,31,32,33,36,37,38,40,41,44,45,46,47,48,49,50,51,52,53,54,56,57,61,62,63,64,66,67,68,74,75,76,77,78,79,80). We have used this experiment of nature to discover 'usual laws of nature' as suggested by William Harvey, and to understand some aspects of more common conditions such as short stature, insulin resistance, diabetes, atherosclerosis, osteoporosis, cancer and ultimately longevity.…”

Section: Introductionmentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

Aguiar‐Oliveira

Souza

Oliveira

et al. 2017

European Journal of Endocrinology

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Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in northeast Brazil, carrying a homozygous mutation in the GH-releasing hormone receptor gene. These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia. Serum concentrations of IGF-I, IGF binding protein type 3 and the acid-labile subunit are markedly reduced, with a lesser reduction of IGF-II. The most striking physical findings of these IGHD individuals are the proportionate short stature, doll facies, high-pitched voice and visceral obesity with reduced fat-free mass. There is neither microphallus, nor neonatal hypoglycemia. Puberty is delayed, menopause anticipated, but fertility is preserved in both genders. The reduction in bone sizes is not even, with mean standard deviation scores for height of −7.2, total maxillary length of −6.5, total facial height of −4.3 and cephalic perimeter of −2.7. In addition, the non-osseous growth is not uniform, preserving some organs, like pancreas, liver, kidney, brain and eyes, and compromising others such as thyroid, heart, uterus and spleen. These subjects present higher prevalence of dizziness, mild high-tones sensorineural hearing loss, reduction of vascular retinal branching points, increase of optic disk, genu valgum and increased systolic blood pressure. Biochemically, they have high low density lipoprotein cholesterol and C-reactive protein levels, but maintain increased insulin sensitivity, and do not show premature atherosclerosis. Finally, they have normal immune function, and normal longevity. This review details the findings and summarizes 20 years of clinical research carried out in this unique population.

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Section: Bone Growth and Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

Aguiar‐Oliveira

Souza

Oliveira

et al. 2017

European Journal of Endocrinology

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“…Growth hormone deficiency (GHD) is a type of growth disorder which is caused by growth hormone (GH) deficiency or inadequate secretion of GH due to hypothalamus or anterior pituitary dysfunction ( 1 , 2 ). It is a common disorder of the endocrine system in children.…”

Section: Introductionmentioning

confidence: 99%

An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency

Xue

Gao

Wang

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to examine the effects of different doses of recombinant human growth hormone (rhGH) on children with growth hormone deficiency (GHD) and on thyroid and glucose metabolism to identify more reasonable therapeutic doses of growth hormone (GH) for the treatment of this condition. In total, 60 prepubertal patients with GHD were randomly divided into the high-dose and low-dose groups (n=30 per group). The groups were treated with 0.1 or 0.05 U/kg for 6 months, respectively. The follow-up study focused on changes to the serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein (IGFBP)-3, blood glucose, thyroid hormone [triiodothyronine (T3) and its prohormone, thyroxine (T4), and thyroid stimulating hormone (TSH)] and the analysis of variance of the repeated data. Changes in the height, body weight and bone age of the high-dose group were greater than those of the low-dose group. After 6 months of treatment, the difference in height between the two groups was statistically significant (P<0.05). Glucose metabolism in the two groups was consistent, but there was a statistically significant difference in the fasting blood glucose (FBG) levels of the two groups after 6 months of treatment (P<0.05). Prior to treatment, the T3, T4 and TSH values (the thyroid function tests) in the two groups, especially for the value of T3 in high-dose group were varied. However, 6 months after treatment, statistically significant differences between the two groups (P<0.05) were identified. In conclusion, 0.1 U/kg of GH is beneficial to children with GHD in attaining a satisfactory height, but it leads to insulin resistance. Thus, glucose metabolism and thyroid function should be monitored on a regular basis in a clinical setting.

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“…Commonly, the Karsect HT-9 microphone is used among Brazilian professionals because it also provides the interface Andrea PureAudio™ USB-SA (Andrea Electronics) (15)(16)(17)(18) . International studies commonly use the Shure SM58 microphone (19)(20)(21)(22) coupled with high-quality recording interfaces. It is important to obtain scientific evidence to support the use of different types of microphones in the Brazilian clinic routine.…”

Section: Discussionmentioning

confidence: 99%

Análise acústica da voz: comparação entre dois tipos de microfones

Krik

Ribeiro

Siqueira

et al. 2019

Audiol., Commun. Res.

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RESUMO Objetivo Comparar os valores das medidas acústicas da voz, extraídas de gravações vocais realizadas com dois tipos de microfones. Métodos Participaram da pesquisa 103 pessoas do sexo feminino, com idades entre 18 e 54 anos. Foram coletadas amostras da vogal sustentada /e/, captadas por dois microfones, simultaneamente: Shure SM58 e Karsect HT-9. Foi realizada a análise acústica das vozes, com a extração de valores de frequência fundamental (F0), variação da frequência (Jitter) e variação de amplitude dos segmentos fundamentais da voz (Shimmer) e proporção Glottal to Noise Excitation (GNE). Resultados Houve diferenças entre os microfones apenas na medida de Shimmer, com predomínio de valores mais altos captados pelo Karsect HT-9. Porém, os resultados de ambos os microfones estiveram dentro dos padrões de normalidade do software utilizado. Conclusão Os resultados da análise acústica extraídos a partir da gravação de voz realizada com os microfones Shure SM58 e Karsect HT-9 foram semelhantes, concluindo-se que ambos os microfones podem ser utilizados para gravação do sinal sonoro na análise acústica.

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Voice Formants in Individuals With Congenital, Isolated, Lifetime Growth Hormone Deficiency

Cited by 20 publications

References 17 publications

MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency

Análise acústica da voz: comparação entre dois tipos de microfones

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