Voice‐ and swallow‐related quality of life in idiopathic <scp>P</scp>arkinson's disease

Hooren, Michel R. A. van; Baijens, Laura W. J.; Vos, Reinder; Pilz, Walmari; Kuijpers, Laura Maria Francisca; Kremer, Bernd; Michou, Emilia

doi:10.1002/lary.25481

Cited by 38 publications

(28 citation statements)

References 29 publications

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“…In the present study, the amount of physical activity performed by patients had swallowing or eating disability sequelae was significantly lower than that performed by patients who did not. This result is similar to that reported in a previous study that patients with Parkinson’s disease had worsened swallowing disorders as their disease progressed, and this lowered their quality of life 32 ) . Therefore, more active interventions based on the prescription of a rehabilitation doctor, such as electrotherapy of the muscles related to dysphagia, are required.…”

Section: Discussionsupporting

confidence: 91%

Correlations between the sequelae of stroke and physical activity in Korean adult stroke patients

Kim

Chun

2016

J Phys Ther Sci

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[Purpose] The present study investigated a wide range of stroke patients living in South Korea using the Korean Community Health Survey raw data to determine the correlation between stroke and physical activity. [Subjects and Methods] This study used raw data from the 2012 Korean Community Health Survey. The total number of participants was 228,921; of the 4,475 stroke patients who had been diagnosed by a medical doctor or an oriental medical doctor, the data for 4,460 patients, excluding 15 whose amount of physical activity was unclear, were used in the analysis. [Results] The amount of physical activity performed by patients who had sequelae was significantly lower than that performed by patients who no longer had sequelae. Similarly, for the type of sequelae, palsy in the arms and legs, facial palsy, communication disability, swallowing or eating disability, and visual disability were associated with lower physical activity. Furthermore, as the number of sequelae increased, patients performed significantly less physical activity. [Conclusion] The findings suggest that when decisions on national policies and budgets are made, methods for increasing the physical activity of patients with a history of stroke should be considered.

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Section: Discussionsupporting

confidence: 91%

Correlations between the sequelae of stroke and physical activity in Korean adult stroke patients

Kim

Chun

2016

J Phys Ther Sci

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“…Additionally, clinical reports describe a predisposition to development of lung infections by PD patients, and to embolism and allergic reactions, compared with the general population (Hampson, Kieburtz, LeWitt, Leinonen, & Freed, ; Letsiou et al., ; Owolabi et al., ). Furthermore, areas in the brain responsible for the operation of swallowing and coughing movements can be downregulated in PD; therefore, lung infections in those patients could be associated with dysphagia (Hinkel et al., ; Schiffer & Kendall, ; van Hooren et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…Breathing problems are recognized as a cause of morbidity and mortality in patients with Parkinson's disease (PD), caused by neural damage in specific regions of the ventral medulla that are responsible for rhythm generation and chemoreception, such as the preBötzinger c 2019 The Authors. Experimental Physiology c 2019 The Physiological Society complex (preBötC) and retrotrapezoid nucleus (RTN), respectively movements can be downregulated in PD; therefore, lung infections in those patients could be associated with dysphagia (Hinkel et al, 2016;Schiffer & Kendall, 2018;van Hooren et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Respiratory disturbances in a mouse model of Parkinson's disease

Oliveira

Moriya

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and its importance?A mouse model of PD has reduced neurokinin‐1 receptor immunoreactivity in the pre‐Bӧtzinger complex and Phox2b‐expressing neurons in the retrotrapezoid nucleus. The PD mouse has impairments of respiratory frequency and the hypercapnic ventilatory response. Lung collagen deposition and ribcage stiffness appear in PD mice. Abstract Parkinson's disease (PD) is a neurodegenerative motor disorder characterized by dopaminergic deficits in the brain. Parkinson's disease patients may experience shortness of breath, dyspnoea, breathing difficulties and pneumonia, which can be linked as a cause of morbidity and mortality of those patients. The aim of the present study was to clarify whether a mouse model of PD could develop central brainstem and lung respiratory abnormalities. Adult male C57BL/6 mice received bilateral injections of 6‐hydroxydopamine (10 μg μl−1; 0.5 μl) or vehicle into the striatum. Ventilatory parameters were assessed in the 40 days after induction of PD, by whole‐body plethysmography. In addition, measurements of respiratory input impedance (closed and opened thorax) were performed. 6‐Hydroxydopamine reduced the number of tyrosine hydroxylase neurons in the substantia nigra pars compacta, the density of neurokinin‐1 receptor immunoreactivity in the pre‐Bӧtzinger complex and the number of Phox2b neurons in the retrotrapezoid nucleus. Physiological experiments revealed a reduction in resting respiratory frequency in PD animals, owing to an increase in expiratory time and a blunted hypercapnic ventilatory response. Measurements of respiratory input impedance showed that only PD animals with the thorax preserved had increased viscance, indicating that the ribcage could be stiff in this animal model of PD. Consistent with stiffened ribcage mechanics, abnormal collagen deposits in alveolar septa and airways were observed in PD animals. Our data showed that our mouse model of PD presented with neurodegeneration in respiratory brainstem centres and disruption of lung mechanical properties, suggesting that both central and peripheral deficiencies contribute to PD‐related respiratory pathologies.

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“…For example, PD affects voice and speech in up to 90% of patients [16], compromising health, employment, social engagement, and quality of life [17, 18, 19]. These voice and speech deficits are mostly refractory to standard of care medical treatment (levodopa) [20] or surgical treatment (deep brain stimulation) [21, 22].…”

Section: Introductionmentioning

confidence: 99%

Vocalization development in common marmosets for neurodegenerative translational modeling

Jones

Duffy

Hoffman

et al. 2018

Neurological Research

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Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1–149 days in a naturalistic setting without any vocalization elicitation protocol. Vocalizations were coded for call type (cry, tsik, trill, phee, and trill-phee) and analyzed for duration (sec), minimum & maximum frequency (Hz), and bandwidth (Hz). Mixed model linear regressions were performed to assess the effects of age on call parameters listed above for each call type. Results Cries decreased in duration (p=0.038), maximum frequency (p=0.047), and bandwidth (p=0.023) with age. Tsik calls decreased in duration (p=0.002) and increased in minimum frequency (p=0.004) and maximum frequency (p=0.005) with age. Trill calls increased in duration (p=0.003), and trillphee bandwidth (p=0.031) decreased with age. Discussion Our results demonstrate that development of common marmoset vocalizations is call type-dependent and that changes in acoustic parameters can be detected without complex vocalization elicitation paradigms or specialized audio recording equipment. Thus, we demonstrate the feasibility of a naturalistic protocol to collect and objectively analyze marmoset vocalizations longitudinally. This approach may be useful for studying vocal communication deficits in genetic models of neurodegenerative disorders.

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Voice‐ and swallow‐related quality of life in idiopathic Parkinson's disease

Abstract: 2b.

Cited by 38 publications

References 29 publications

Correlations between the sequelae of stroke and physical activity in Korean adult stroke patients

Correlations between the sequelae of stroke and physical activity in Korean adult stroke patients

Respiratory disturbances in a mouse model of Parkinson's disease

Vocalization development in common marmosets for neurodegenerative translational modeling

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