Vogt-Koyanagi-Harada Syndrome: Case Report

Jordão, Clarice; Sodré, Celso Tavares

doi:10.4172/2376-0427.1000181

Cited by 1 publication

(2 citation statements)

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“…Vogt-Koyanagi-Harada (VKH) disease is a rare systemic disease with unknown pathogenesis, in which organs containing melanoblasts like ocular, inner ears, meninges, and especially skin are involved (3)(4)(5). There is controversy about the pathogenesis of VKH.…”

Section: Introductionmentioning

confidence: 99%

“…Many researchers believe in the autoimmune basis for this disease because of the elevated blood level of interleukin B53, gamma interferon inhibitor, and increased IL-10 activity. Its protection against autoimmune diseases is significantly lower than normal subjects (3). Other researchers suggest that some viral infections may be the basis of pathophysiology; whereas the onset of the disease is with flu-like symptoms (4).…”

Section: Introductionmentioning

confidence: 99%

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Vogt-Koyanagi-Harada Disease Presenting as a Schizophrenia Spectrum Disorder: A Case Report

Kheradmand

Safarzadeh

2022

Iran J Psychiatry Behav Sci

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Introduction: Numerous autoimmune disorders accompany with psychosis. The Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disease with no reports about its concomitance with psychosis so far. Case Presentation: We report the co-occurrence of schizophrenic spectrum diseases with VKH for the first time. They have common manifestations such as aggression, agitation, and self-talking, subsiding after chemotherapy. Workup evaluation was performed by computed tomography (CT) scan, magnetic resonance imaging (MRI), electroencephalography (EEG), lumbar puncture (LP) study, IQ test, lab tests for hepatitis and other infections, and retinal angiography and sonography. The patient underwent corticosteroid therapy, immunosuppressive therapy, risperidone, propranolol, and trihexyphenidyl. Conclusions: Our results showed the significant role of autoimmunity in the genesis of psychosis. On the other hand, unusual manifestations and slow response to treatment in these patients show that autoimmune disorders with psychosis may worsen the prognosis of psychosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%