“…The vertical dotted line indicates no differences in relapse risk with drug vs. placebo with sound antipsychotic treatment of patients with chronic psychotic disorders. Speci fi c forms of behavioral, educational, and family interventions with a supportive or rehabilitative orientation, in particular, can add substantially to the stability of antipsychotic-treated chronically psychotic patients, often reducing relapse rates by more than 50% compared to drug-alone for up to 2 years [ 109,120,165,217,234 ] . Overall, typical 1-year outcomes in patients diagnosed with schizophrenia average approximately 85% relapse risk without speci fi c treatment, perhaps 5-10% less with a placebo, about 70% relapse risk with psychosocial treatment only, 25% with an antipsychotic drug alone, and perhaps 10% risk with both medicine and psychosocial treatment.…”