[VIVO]2+ complexes: Structure, unusual magnetic properties and cytotoxic effect

Hernández-Benítez, L. Joshua; Jiménez-Cruz, Pamela; Cureño-Hernández, Karla E.; Peralta, Alejandro; Flores‐Álamo, Marcos; Flores‐Parra, Angelina; Gracia-Mora, Isabel; Castillo‐Blum, Silvia E.

doi:10.1016/j.ica.2018.05.013

Cited by 8 publications

(1 citation statement)

References 51 publications

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“…For example, sodium orthovanadate has been shown to re-sensitize CEM/VLB We note that Schiff base complexes of [V IV O] 2+ have recently been screened against human tumour cell lines (HeLa and HCT-15), and, for some of the complexes, activities greater than cisplatin were observed. [19] Entry into this high-valent vanadium chemistry is via the use of the starting materials [VO(acac)2], [VOCl3] and [VOSO4]; the use of [VO(acac)2] has been reviewed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure, and cytotoxicity studies of oxidovanadium(IV and V) complexes bearing chelating phenolates

et al. 2019

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The interaction of [VO(acac)2] with 2,6-bis(hydroxymethyl)-4-methylphenol (L 1 H3) or 6,6 /methylenebis(4-tert-butyl-2-(hydroxymethyl)phenol) (L 2 H4) in refluxing toluene afforded, following work-up in ethanol, the complexes [VOL 1 ]2 (1) and {[VO(acac)(HOEt)](VO)L 2 ]}2 (2), respectively. Use of 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid (L 3 H2) or 4-[3,5-bis(2hydroxyphenyl)-1,2,4-triazol-1-yl]benzosulfonic acid (L 4 H2) with [VOCl3] in refluxing acetonitrile, followed by methanol and THF work-up, afforded the complexes [Et3NH][VO(OMe)L 3 ]2 (3) and [Et3NH][VO(OMe)L 4 ]2 (4), respectively. The interaction of [VOSO4] and L 3 H2 in refluxing acetonitrile afforded, with extraction into methanol, the complex [VO(OMe)L 3 ]2 (5). The molecular structures of 2, 3 and 5 have been determined; the structure of 1 has been reported previously. The complexes in this study have been determined to be of low toxicity using in vitro cell assays with 50% cytotoxicity values (CC50) values in the range 56 -126 µM.

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Section: Introductionmentioning

confidence: 99%