Vitrification and Nanowarming of Kidneys

Sharma, Anirudh; Rao, Joseph Sushil; Han, Zonghu; Gangwar, Lakshya; Namsrai, Baterdene; Gao, Zhe; Ring, Hattie L.; Etheridge, Michael L.; Wowk, Brian; Fahy, Gregory M.; Finger, Erik B.; Bischof, John C.

doi:10.1016/j.cryobiol.2021.11.044

Cited by 3 publications

(2 citation statements)

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“…It is confirmed that MNPs could improve the vitrification efficiency of immature mouse oocytes as a vitrification aid [13]. Sharma et al perfused a cryoprotective cocktail and silica-coated MNPs into a kidney and discovered that the growth of ice crystals could be avoided by nanowarming [14]. Hence, we propose the application of MNPs in the freezing-thawing process of aquatic products to enhance their glass transition temperature, inhibit ice nucleation and growth, and ensure superior quality.…”

Section: Introductionmentioning

confidence: 58%

Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics

Wang,

Li,

et al. 2023

Foods

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The presence of magnetic nanoparticles (MNPs) suppresses ice nucleation and growth during freezing and thawing. In this study, the effects of MNPs-assisted cryogenic freezing integrated with MNP-combined microwave thawing (NNMT) on the thermodynamic and quality changes of salmon fillets were investigated. Results have shown that NNMT raises Tg (glass transition temperature) and Tmax (transition temperature), thus improving the storage stability of salmon fillets. MNPs-assisted freezing and thawing treatment, especially NNMT treatment, significantly improved the water holding capacity, texture, color, and other quality characteristics of salmon fillets. In addition, the lipid and protein oxidation degrees of the NNMT treatment were the lowest, while the myofibrillar protein solubility of NNMT was the highest (87.28%). This study demonstrated that NNMT has minimal impact on the freezing–thawing quality of salmon fillets, making it a more suitable option for the preservation of aquatic foods.

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Section: Introductionmentioning

confidence: 58%

Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics

Wang,

Li,

et al. 2023

Foods

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“…The ac field causes rapid magnetization reversal and therefore induction loss, which manifests as heat. Sharma et al [ 39 ] recently found that various magnetic nanoparticles can also be dispersed in cryopreservation agents (CPAs), which are biocompatible anti-freeze solutions that protect tissues and organs as they are vitrified in liquid nitrogen. To maintain viability as the specimens are warmed back to room (or body) temperature, the heating must be uniform to avoid cracking and rapid to avoid devitrification.…”

Section: Nanowarmersmentioning

confidence: 99%

Bioapplications of Magnetic Nanowires: Barcodes, Biocomposites, Heaters

Kouhpanji

Zhang

et al. 2022

IEEE Trans. Magn.

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Magnetic nanowires (MNWs) can have their moments reversed via several mechanisms that are controlled using the composition, length, diameter, and density of nanowires in arrays as-synthesized or as individual nanoparticles in assays or gels. This tailoring of magnetic reversal leads to unique properties that can be used as a signature for reading out the type of MNW for applications as nano-barcodes. When synthesized inside track etched polycarbonate membranes, the resulting MNW-embedded membranes can be used as biocompatible bandaids for detection without contact or optical sighting. When etched out of the growth template, free-floating MNWs are internalized by cells at 37ºC, such that cells and/or exosomes can be collected and detected. In applications of cryopreservation, MNWs can be suspended in cryopreservation agents for injection into the blood vessels of tissues and organs as they are vitrified to -200ºC. Using an alternating magnetic field, the MNWs can then be nanowarmed rapidly to prevent crystallization and uniformly to prevent cracking of specimens, for example as grafts or transplants. This invited paper is a review of recent progress in the specific bioapplications of MNWs to barcodes, biocomposites, and nanowarmers.

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Applying soft matter techniques to solve challenges in cryopreservation

Bryant

Elbourne

Greaves

et al. 2023

Front. Soft. Matter

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Cryopreservation allows the long-term storage of biological material, and has become integral for numerous applications including assisted reproductive technologies, stem cell therapies, blood banking, and species preservation. However, there are still hundreds of cell types that cannot be cryopreserved, and no organs at all. The biggest challenge facing cryopreservation is the ongoing reliance on predominantly just two cryoprotectants (dimethylsulfoxide and glycerol) as well as physical limitations to heating and cooling rates. The field of soft matter can accelerate cryopreservation research by providing insights into the underlying mechanisms and interactions of cells, cryoprotectants, and solvents including the role of temperature. With techniques as far ranging as differential scanning calorimetry, atomic force microscopy, and neutron and X-ray scattering, it is possible to probe multiple length and time scales in order to identify and characterise important interactions. This in turn can lead to the development of new cryoprotectants, and new methods of heating/cooling which could overcome some of the current challenges of cryopreservation.

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Vitrification and Nanowarming of Kidneys

Cited by 3 publications

References 0 publications

Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics

Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics

Bioapplications of Magnetic Nanowires: Barcodes, Biocomposites, Heaters

Applying soft matter techniques to solve challenges in cryopreservation

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