Vitreous Substitutes: Old and New Materials in Vitreoretinal Surgery

Alovisi, Camilla; Panico, Claudio; Sanctis, Ugo de; Eandi, Chiara M

doi:10.1155/2017/3172138

Cited by 53 publications

(71 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More details about these vitreous substitutes can be found in several review articles. 53,[144][145][146][147][148][149][150][151][152][153][154] Most current experimental hydrogel vitreous substitutes have moduli that are orders of magnitude higher than those of the human vitreous (Table 4 and Figure 4A). However, stiff hydrogels can be difficult to inject through a small gauge needle into the vitreous chamber.…”

Section: The Strive For Improved Vitreous Substitutes and Intraocularmentioning

confidence: 99%

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

View full text Add to dashboard Cite

Research on the vitreous humor and development of hydrogel vitreous substitutes have gained a rapid increase in interest within the past two decades. However, the properties of the vitreous humor and vitreous substitutes have yet to be consolidated. In this paper, the mechanical properties of the vitreous humor and hydrogel vitreous substitutes were systematically reviewed. The number of publications on the vitreous humor and vitreous substitutes over the years, as well as their respective testing conditions and testing techniques were analyzed. The mechanical properties of the human vitreous were found to be most similar to the vitreous of pigs and rabbits. The storage and loss moduli of the hydrogel vitreous substitutes developed were found to be orders of magnitude higher in comparison to the native human vitreous. However, the reported modulus for human vitreous, which was most commonly tested in vitro, has been hypothesized to be different in vivo. Future studies should focus on testing the mechanical properties of the vitreous in situ or in vivo. In addition to its mechanical properties, the vitreous humor has other biotransport mechanisms and biochemical functions that establish a redox balance and maintain an oxygen gradient inside the vitreous chamber to protect intraocular tissues from oxidative damage. Biomimetic hydrogel vitreous substitutes have the potential to provide ophthalmologists with additional avenues for treating and controlling vitreoretinal diseases while preventing complications after vitrectomy. Due to the proximity and interconnectedness of the vitreous humor to other ocular tissues, particularly the lens and the retina, more interest has been placed on understanding the properties of the vitreous humor in recent years. A better understanding of the properties of the vitreous humor will aid in improving the design of biomimetic vitreous substitutes and enhancing intravitreal biotransport.

show abstract

Section: The Strive For Improved Vitreous Substitutes and Intraocularmentioning

confidence: 99%

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

View full text Add to dashboard Cite

show abstract

“…And Vitreous tamponade aims to replace the natural vitreous body with vitreous substitutes to support the retina, promote the anatomical reduction of the retina and prevent the eyeball from shrinking [5,12]. But current discovered vitreous substitutes have short-term life-span and high toxicity causing severe complications in the eyes [13,14]. Specially, SO has been proved to be toxic for ciliary body and attribute to emulsificate in the eyeball, though SO has the most stable physical and chemical attributions among all the vitreous substitutes [15].…”

Section: Introductionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

View full text Add to dashboard Cite

Background: Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods: A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar-Bowker test. Results: In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions: FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

show abstract

“…Cross-linked hydrogels are synthetic polymer networks that are expanded throughout their volume by water. Smart hydrogels can create a three-dimensional structure characterized by transparency, biocompatibility, and mechanical flexibility [ 196 ]. These polymers have only been used on an experimental basis and, at this time, their major disadvantage is the intravitreal inflammation due to immune system activation [ 197 ].…”

Section: Late Onset Silicone Oil-induced Glaucomamentioning

confidence: 99%

Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Nicolai

Lassandro

Franceschi

et al. 2020

Vision

View full text Add to dashboard Cite

Silicone oil represents the main choice for intraocular tamponade in cases of complicated retinal detachment surgery. The intraocular pressure of an eye filled with silicone oil could increase, driven by a variety of different forces, according to several mechanisms. Two main conditions have been highlighted, depending on the onset: early hypertension or late glaucoma. The different types of silicone oils and their physico-chemical properties are varied and may play a role in the determination of intraocular pressure rise. The current body of literature allows for the illustration and categorization of the incidence and risk factors, as well as the pathogenesis and the management of the early postoperative hypertension subtended by an open- and closed-angle, along with the late onset silicone oil-induced glaucoma. Understanding the leading actors on the stage of ocular pressure elevation concurrently with silicone oil application for retinal surgery could help in guiding the timely and appropriate course of treatment.

show abstract

Vitreous Substitutes: Old and New Materials in Vitreoretinal Surgery

Cited by 53 publications

References 40 publications

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Contact Info

Product

Resources

About