Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Nicolai, Michele; Lassandro, Nicola Vito; Franceschi, Alessandro; Rosati, Alessandro; Turris, Serena De; Pelliccioni, Paolo; Pirani, Vittorio; Mariotti, Cesare

doi:10.3390/vision4030036

Cited by 22 publications

(14 citation statements)

References 189 publications

(315 reference statements)

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“…Of note, SO can block the pupil or migrate into the anterior chamber following vitreoretinal surgery. In eyes with long-term SO endotamponade, the emulsified SO droplets in the Schlemm's canal may predispose to IOP elevation and development of glaucoma post-vitrectomy (Choi et al 2020;Nicolai et al 2020;Aktas et al 2021).…”

Section: Results In Context With the Published Literaturementioning

confidence: 99%

Risk of glaucoma after vitreoretinal surgery – Findings from a population‐based cohort study

Loukovaara

Gucciardo

Korhonen

et al. 2022

Acta Ophthalmologica

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Purpose To investigate the association between different types of vitrectomy and risk of different types of glaucoma and to determine the effect of systemic medication and diabetes status on this risk. Methods A population‐based nested case–control study included individuals of age ≥ 18 years who had undergone single vitrectomy, vitrectomy with retinal procedure, or combined phaco‐vitrectomy between 2001 and 2010. End of follow‐up was 2017. Odds ratio (OR) for the development of glaucoma after different types of vitrectomy and 95% confidence interval (CI) were based on conditional logistic regression models. For every glaucoma case, five controls were matched by age, sex, start of follow‐up year, and hospital district. Results The cohort (n = 37 687), of which 52.8% was female, consisted of 6552 individuals diagnosed with glaucoma and 31 135 controls matched by age, sex, and hospital district. Vitrectomy was performed on 103 eyes in the glaucoma group and 158 eyes in the control group. As regards the risk of any glaucoma, the risk was lowest in eyes that underwent combined phaco‐vitrectomy (OR: 2.7, 95% CI: 1.8–4.1), followed by single vitrectomy (OR: 3.15, 95% CI: 2.1–4.8), and highest in eyes that underwent vitrectomy with retinal procedure (OR: 4.5, 95% CI: 2.7–7.4). Diabetes had no effect (OR: 0.96, 95% CI: 0.92–1.01), but 5‐year systemic statin use slightly decreased glaucoma risk (OR: 0.86, 95% CI: 0.77–0.97). Conclusions Vitreoretinal surgery was associated with an increased glaucoma risk; the risk being related to the complexity of vitrectomy. Long‐term systemic statin therapy may decrease glaucoma risk, while diabetes had no association.

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Section: Results In Context With the Published Literaturementioning

confidence: 99%

Risk of glaucoma after vitreoretinal surgery – Findings from a population‐based cohort study

Loukovaara

Gucciardo

Korhonen

et al. 2022

Acta Ophthalmologica

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“…However, several complications arise with the long-term use of SO as vitreous substitute which includes its emulsification resulting in cataract formation, glaucoma, corneal toxicity, band keratopathy [ 60 , 61 ]. In order to avoid these complications, surgical removal of silicone oil becomes a necessity, although risk of retinal detachment is associated with the removal process.…”

Section: Currently Used Vitreous Substitutes In Clinicsmentioning

confidence: 99%

Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective

2020

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Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.

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“…However, the disadvantages of the emulsification and toxicity of SO limit its clinical application. 3 For the patients who cannot tolerate SO complications, a permanent or long-term vitreous substitute is in great need. In order to use for long-term, the vitreous substitute has to be nondegradable, transparent, biocompatible, and in stable conditions, which is challenging to achieve and need further evaluation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Foldable Capsular Vitreous Body Implantation Surgery

Luo¹,

Wei²,

Liu³

et al. 2022

IJGM

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Background Foldable capsular vitreous body (FCVB), a novel artificial vitreous substitute product, has been used clinically in recent years. The aim of this study was to evaluate the outcomes and complications of FCVB implantation surgery during the postoperative period. Methods We performed a prospective, nonrandomized study from November 2021 to March 2022. Eight patients with severe retinal detachment that could not be easily reattached were included in this study. Before and after surgery, visual acuity (VA), intraocular pressure (IOP), slit-lamp microscopy, optical coherence tomography (OCT), B-scan and CT were performed. Results After the operation, the FCVB was well distributed in the vitreous cavity and supported the retina according to the B-scan and CT images. During the follow-up period, no vitreous hemorrhage or retinal detachment was found in any of the patients. On the first postoperative day, the average IOP increased from 9.6 ± 7.7 mmHg preoperatively to 13.8 ± 14.3 mmHg. Although the IOP of two patients fell outside the normal range, IOP was finally held steady after the fifth postoperative day in all cases. In addition, three patients (37.5%) experienced eye ache, and after taking a Saridon tablet, the pain was greatly alleviated. Moreover, no adverse events, such as silicone oil (SO) spillage and emulsification or serious complications, were observed. Conclusion The current vitreous substitute FCVB is effective and safe for treating complicated retinal detachments in ophthalmic applications. Further multiple-center clinical designs should focus on indications and complications of FCVB during long-term follow-up periods.

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Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Cited by 22 publications

References 189 publications

Risk of glaucoma after vitreoretinal surgery – Findings from a population‐based cohort study

Risk of glaucoma after vitreoretinal surgery – Findings from a population‐based cohort study

Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective

Evaluation of Foldable Capsular Vitreous Body Implantation Surgery

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