Evaluation of Foldable Capsular Vitreous Body Implantation Surgery

Abstract

Background Foldable capsular vitreous body (FCVB), a novel artificial vitreous substitute product, has been used clinically in recent years. The aim of this study was to evaluate the outcomes and complications of FCVB implantation surgery during the postoperative period. Methods We performed a prospective, nonrandomized study from November 2021 to March 2022. Eight patients with severe retinal detachment that could not be easily reattached were included in this study. Before and after surgery, visual acuity (VA), intraocular pressure (IOP), slit-lamp microscopy, optical coherence tomography (OCT), B-scan and CT were performed. Results After the operation, the FCVB was well distributed in the vitreous cavity and supported the retina according to the B-scan and CT images. During the follow-up period, no vitreous hemorrhage or retinal detachment was found in any of the patients. On the first postoperative day, the average IOP increased from 9.6 ± 7.7 mmHg preoperatively to 13.8 ± 14.3 mmHg. Although the IOP of two patients fell outside the normal range, IOP was finally held steady after the fifth postoperative day in all cases. In addition, three patients (37.5%) experienced eye ache, and after taking a Saridon tablet, the pain was greatly alleviated. Moreover, no adverse events, such as silicone oil (SO) spillage and emulsification or serious complications, were observed. Conclusion The current vitreous substitute FCVB is effective and safe for treating complicated retinal detachments in ophthalmic applications. Further multiple-center clinical designs should focus on indications and complications of FCVB during long-term follow-up periods.

Study on Maintenance of Eyeball Morphology by Foldable Capsular Vitreous Body in Severe Ocular Trauma

“…It provides stable support against the retina, which helps avoid the intraocular toxicity caused by direct contact with the lling medium with the intraocular tissues and thus reduces the chances of developing relevant complications caused by the vitreous substitutes, while restoring the shape maintenance and support function of the vitreous body of the globe, eliminating the patient's need for enucleation [4,6,9] . However, even though FCVB has been validated via in vivo experiments [10] and has been widely applied clinically [6,9,[11][12][13] , there has been a lack of convincing evidence to corroborate its therapeutic effect and safety in the case of severe ocular trauma. In this retrospective study, we evaluated the feasibility of FCVB in the severe case setting via a systematic review of 61 cases of FCVB procedures performed in our hospital during 2018-2019.…”