Vitiligo and melanoma‐associated hypopigmentation (MAH):shared and discriminative features

Hartmann, Anke; Bedenk, Christina; Keikavoussi, Petra; Becker, Jürgen C.; Hamm, Henning; Bröcker, Eva‐Bettina

doi:10.1111/j.1610-0387.2008.06755.x

Cited by 54 publications

(53 citation statements)

References 28 publications

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“…The aetiology of this disorder is unclear, but there are at least three theories, including autoimmune, autocytotoxic, and neural hypotheses. Autoimmune mechanisms are widely discussed as a possible cause, and this is supported by genetic predisposition, association with (other) autoimmune diseases as well as the presence of antimelanocytic antibodies and lesional lymphohistiocytic inflammatory infiltrates (6)(7)(8)(9). Furthermore, a complex biochemical imbalance with defective free-radical defence, in which redox enzymes play an important role, could interfere with melanin content and synthesis (10,11).…”

mentioning

confidence: 99%

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

Hofmann¹,

Bröcker²,

Hamm³

2009

Acta Derm Venerol

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Unlike in common melanocytic naevi, an acquired leukoderma (halo) surrounding a congenital melanocytic naevus is a rare phenomenon. A 6-year-old boy developed a depigmentation around a congenital melanocytic naevus on the right thigh. Simultaneously, segmental vitiligo appeared on the thigh, lower abdomen and buttock of the same side with sharp midline demarcation. Examination for associated autoimmune diseases proved negative. The simultaneous occurrence of a halo phenomenon around a congenital melanocytic naevus and segmental vitiligo, as well as identical histological and immunohistological findings in both pigmented lesions, suggest shared immunological mechanisms.

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confidence: 99%

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

Hofmann¹,

Bröcker²,

Hamm³

2009

Acta Derm Venerol

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“…a mild adverse effect, and therefore, no further action is required. Drug-induced vitiligo shows different characteristics to classical vitiligo from the epidemiological point of view: an absent family history, partial discoloration, a wayward patchy distribution and a rapid development after the introduction of the drug, as in our case (1).…”

Section: Can Vemurafenib Induce Vitiligo In Metastaticmentioning

confidence: 67%

Can Vemurafenib Induce Vitiligo in Metastatic Melanoma Patients?

Ruiz‐Villaverde

Cano²

2016

Balkan Med J

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Melanoma is a mucocutaneous or ocular, sporadic or familial, neoplasm that is associated with a range of genetic factors. Environmental predisposing factors include the exposure to intense sunlight associated with sunburn, as well as a type II phototype. Between 1.5% and 20% of patients with melanoma may have vitiligo-like lesions. From a clinical point of view, the latter may be classified as: a) lesions adjacent to the primary melanoma or metastatic regression; b) development of a melanocytic nevi nevus halo on pre-existing nevi; or c) vitiliginous lesions at sites distant to the melanoma, whether isolated or associated with the ocular findings of Vogt-KoyanagiHarada syndrome. We report this relationship of vitiligo-like lesions in a patient with a metastatic melanoma who attended our Unit for treatment with vemurafenib.A 56 year-old male, with no past medical history, was referred to our outpatient clinic complaining about a cutaneous lesion on his back, which had developed abnormal changes for 2 years. With a clinical diagnosis of typical nevi, the patient had the lesion excised. Histological examination revealed superficial spreading melanoma (SSM), absence of ulceration, a 1.9 mm Breslow Depth Index, and a Clark IV Level with positive sentinel node.An elective lymph node dissection was required, and the presence of micrometastases was observed in three nodes (Stage IIIA). BRAF (Serine Threonine kinase B raf) V600E mutation in primary tumor and lymph node were analyzed, with a positive result in both cases. After evaluation of the case by our Hospital Oncological Committee, treatment with 960 mg Vemurafenib (Roche; Basel, Switzerland) twice daily was started.Eight weeks later, vitiligo-like depigmented macules developed on the patient's neckline (Figure 1). The examination with a Wood's lamp revealed similar lesions on the periocular and perioral area. A skin biopsy was then performed, showing a loss of melanocytes on the basal layer in the excised area.After ten months of treatment, the patient remains tumorfree, according to the imaging tests performed, and is under periodic follow-ups by the Units of Dermatology and Oncology. Ethics committee approved the presentation of this case report with academic and research purpose under signed of the informed consent by our patient.

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“…10 Para pacientes com melanoma a chance de desenvolver vitiligo é 7-10x maior comparado com a população geral especialmente quando submetidos a terapia imunológica. 11 As diferenças clínicas entre vitiligo associado a melanoma e o vulgar não são bem definidas: alguns autores consideram idênticos 12 enquanto outros verificaram que o vitiligo associado ao melanoma tem espectro de manifestações clínicas mais variadas. 13 A patogênese da despigmentação no melanoma é provavelmente autoimune com anticorpos contra antígenos dos melanócitos, como a tirosinase encontrados no soro de uma proporção significativa destes patientes.…”

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Melanoma ungueal e vitiligo: relato de caso

Oliveira

Alcântara

Lea

et al. 2015

Medicina (Ribeirão Preto)

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RESUMOO melanoma ungueal é uma forma de apresentação rara do melanoma. É frequente o diagnóstico tardio. Geralmente afeta polegar ou hálux e a maioria dos pacientes é de meia idade ou idosos de pele escura. A associação entre melanoma e vitiligo é tem sido descrita há mais de 50 anos e os pacientes acometidos tem apresentado maior sobrevida sugerindo resposta imune ao melanoma. O objetivo deste relato é descrever um caso de melanoma ungueal com surgimento de linfonodo inguinal e vitiligo associado diagnosticado tardiamente com posterior evolução para doença sistêmica.Palavras-chave: Melanoma. Vitiligo. Doenças da Unha. Recidiva. ABSTRACTSubungual melanoma is a rare clinical entity of melanoma. It usually involves an unsuspecting lesion in the thumb or big toe, thus late diagnosis. Majority of patients are middle-aged or older, usually of dark skin ethnicity. The association between melanoma and vitiligo has been described for over 50 years, showing increased survival rates in affected patients suggesting immune response to melanoma. The objective of this report is to describe a clinical case of nail melanoma, presenting as enlargened unilateral inguinal lymph node associated with rapid and progressive vitiligo. However, investigations proved late diagnosis, with subsequent progression of the disease.

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Vitiligo and melanoma‐associated hypopigmentation (MAH):shared and discriminative features

Abstract: Whereas differences exist concerning associated autoimmune diseases, MAH and vitiligo shared many common clinical and histological features. Further studies are needed to assess the clinical relevance of vitiligo-like alterations in melanoma patients.

Cited by 54 publications

References 28 publications

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

Can Vemurafenib Induce Vitiligo in Metastatic Melanoma Patients?

Melanoma ungueal e vitiligo: relato de caso

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