Vitiligo: A comprehensive overview

Alikhan, Ali; Felsten, Lesley M.; Daly, Meaghan; Petronic‐Rosic, Vesna

doi:10.1016/j.jaad.2010.11.061

Cited by 558 publications

(256 citation statements)

References 194 publications

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“…Vitiligo is an acquired disorder of pigmentation affecting 0.005-8.8% of the world's population [1,2,3,4,5], characterized by the development of white patches on the skin, often with a typical symmetrical distribution and progressive extension. Although vitiligo does not cause direct physical impairment, it is commonly believed that it can produce an important psychosocial burden [6].…”

Section: Introductionmentioning

confidence: 99%

To What Extent Is Quality of Life Impaired in Vitiligo? A Multicenter Study on Italian Patients Using the Dermatology Life Quality Index

et al. 2014

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Background: It is believed that vitiligo has an impact on the overall patient quality of life (QoL). Objective: To estimate QoL in a fairly large sample of Italian vitiligo patients by using the Dermatology Life Quality Index (DLQI) questionnaire. Methods: One hundred and sixty-one vitiligo patients referred to 9 dermatological centers were offered to participate by filling in the Italian version of the DLQI questionnaire. Results: The mean total DLQI score was 4.3 (SD ±4.9; range: 0-22). In multivariate analysis, DLQI >5 was associated with female gender, stability of the disease over time and involvement of the face at disease onset. Conclusions: The impairment of QoL is overall limited in Italian vitiligo patients, especially if it is compared with results from other available studies. This could be due to cultural and ethnic characteristics of the sample.

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Section: Introductionmentioning

confidence: 99%

To What Extent Is Quality of Life Impaired in Vitiligo? A Multicenter Study on Italian Patients Using the Dermatology Life Quality Index

et al. 2014

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“…The association between vitiligo and other autoimmune diseases, such as thyroid disease, psoriasis, and inflammatory bowel disease has been established, supporting an autoimmune etiology [5]. Other studies have proposed the relationship between free radicals and an impaired response of melanocytes to oxidative stress in the pathogenesis of vitiligo [2,6].…”

Section: Introductionmentioning

confidence: 94%

“…The disease is characterized by the development of depigmented macules and patches due to the loss of functioning melanocytes [2,3]. Vitiligo is classified into two broad categories, segmental and non-segmental, with the latter being more common.…”

Section: Introductionmentioning

confidence: 99%

“…Non-segmental vitiligo is classically characterized by a waxing and waning course with depigmentation in a symmetric, bilateral pattern, and includes the generalized, acrofacial, and universal variants [4]. The pathogenesis of the disease has yet to be fully elucidated, although an impaired response to oxidative stress, autoimmunity, inflammatory, and neurogenic components may all play a role [2,4]. The association between vitiligo and other autoimmune diseases, such as thyroid disease, psoriasis, and inflammatory bowel disease has been established, supporting an autoimmune etiology [5].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith¹,

Mohammad²,

Hamzavi³

2017

TODJ

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Background:Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relationship between diet and disease. Objective:To review various dietary modifications and supplementation used in the management of vitiligo. Materials and Methods:A thorough evaluation of recent literature using the keywords "vitiligo, diet, supplement, antioxidant, vitamin, mineral, zinc, copper, gluten-free, celiac disease, alternative medicine" in the NCBI PubMed search function was performed. Results:A total of 39 relevant articles were reviewed and critically evaluated. Conclusion:Initial studies regarding the treatment of vitiligo through dietary modification are promising, although further studies are needed in multiple populations to explore the therapeutic value of these interventions.

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“…The prevalence ranges from 0.1 to 8% worldwide [1]. Various treatment options exist but there is no evidence-based curative therapy, and effective therapeutic regimens are limited.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

et al. 2015

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Background: Systemic corticosteroids have been used to arrest the progression of vitiligo. However, side effects have been a constant issue. Objective: We evaluated the clinical efficacy and side effect of oral methylprednisolone (MPD) mini-pulse therapy combined with narrow-band UVB (NBUVB) for adults with non-segmental vitiligo retrospectively. Methods: 32 patients with extensive and/or spreading vitiligo received 0.5 mg/kg MPD on 2 consecutive days per week with NBUVB therapy for at least 3 months. Results: All of the 32 patients (100%) showed progression arrest within 12 weeks. Nineteen out of 32 patients (59.4%) presented repigmentation on more than 25% of lesions. Thirteen patients (40.6%) achieved satisfactory repigmentation in more than 50% of lesions. Only 2 patients discontinued the medication due to gastrointestinal trouble. Conclusion: Oral MPD mini-pulse therapy combined with NBUVB appears effective in arresting vitiligo progression and rapidly inducing repigmentation with minimal side effects.

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Vitiligo: A comprehensive overview

Cited by 558 publications

References 194 publications

To What Extent Is Quality of Life Impaired in Vitiligo? A Multicenter Study on Italian Patients Using the Dermatology Life Quality Index

To What Extent Is Quality of Life Impaired in Vitiligo? A Multicenter Study on Italian Patients Using the Dermatology Life Quality Index

Assessment of Dietary Supplementation in the Treatment of Vitiligo

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

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