VITEXIN DERIVATIVES AS CHEMICAL MARKERS IN THE DIFFERENTIATION OF THE CLOSELY RELATED SPECIES <i>PASSIFLORA ALATA</i> CURTIS AND <i>PASSIFLORA QUADRANGULARIS</i> LINN

Costa, Geison Modesti; Gazola, Andressa Córneo; Madoglio, Fernanda Angélica; Zucolotto, Silvana Maria; Reginatto, Flávio Henrique; Castellanos, Leonardo; Ramos, Freddy A.; Duque, Carmenza; Schenkel, Eloir Paulo

doi:10.1080/10826076.2012.695316

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…The results of this study also show that the pericarp extract of Passiflora alata has a positive action on sleep induction at higher concentrations which was comparable to the leaf extract. The HPLC‐DAD fingerprint of the extracts used for this investigation revealed the presence of isoorientin, orientin, vitexin‐2”‐ O ‐rhamnoside and isovitexin in the pericarp and leaves extracts of P. alata , and the presence of rutin in the pericarp (Costa et al ., ; Madóglio, ). Furthermore, a quantitative analysis through HPLC‐DAD analysis revealed that apigenin is the major flavonoid compound in the leaves extract and is correlated with the sedative activity (Gazola, ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Sedative Effects of Passiflora edulis f. flavicarpa and Passiflora alata Extracts in Mice, Measured by Telemetry

et al. 2013

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Several Passiflora species have been used widely as a folk medicine due to their sedative and anxiolytic activities. In Brazil, a number of native plants of the genus Passiflora exist, but only Passiflora edulis f. flavicarpa (PE) and Passiflora alata (PA) are of commercial value. Thus, the aim of the present study was to investigate the sedative effects of aqueous extracts obtained from the pericarp as well as from the leaves of PE and PA in mice using radiotelemetry. Aqueous extracts from PE and PA were tested for effects on locomotion over 180 min in 300 mg/kg, 600 mg/kg and 1200 mg/kg, in male C57BL/6J mice after oral administration. For validation of the telemetry system, caffeine (negative control) and midazolam (positive control) were used. All tested extracts decreased locomotor activity in a dose-dependent manner in comparison to the control group. The two lower concentrations of each extract showed the highest decrease in locomotion after 24 min, while 1200 mg/kg had a significant sedative effect already after 18 min. Interestingly, aqueous extracts of PA were more active in comparison to aqueous extracts of PE and the pericarp extracts of both plants showed more pronounced effects on locomotor activity if compared to leaf extracts. In conclusion, the present study represents an innovative, objective approach to measure sedative effects of plant extracts with minimized handling-related stress and remote data collection.

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Section: Discussionmentioning

confidence: 99%

Assessment of Sedative Effects of Passiflora edulis f. flavicarpa and Passiflora alata Extracts in Mice, Measured by Telemetry

et al. 2013

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“…Vitexina, isovitexina, orientina e isoorientina e seus derivados são os metabólitos mais frequentemente encontrados no gênero e, devido à sua alta prevalência, têm sido frequentemente utilizados como marcadores químicos em diferentes estudos (ZUCOLOTTO et al, 2012;COSTA et al, 2013).…”

Section: Composição Químicaunclassified

“…A fração BuOH-2 inicialmente foi analisada no sistema CLAE-DAD-Prep conforme método estabelecido por Costa et al (2013), porém foi utilizada fase móvel composta pelos solventes H2O:MeCN, como fase móvel A e B, respectivamente, ambas contento 0,01% (v/v) de TFa. Após ajustes para condições semipreparativas e definição do tempo de retenção das substâncias de interesse, utilizando esta mesma fase móvel, efetuou-se o fracionamento dessa fração empregando coluna semipreparativa Shimadzu (Shimpack ODS(H); 5,0 μm, 200 mm x 20 mm), com detector operando em λ = 270/320 nm e vazão de 9,0 mL min -1 e o seguinte perfil de eluição: 0-90 min: 13.8 % B (isocratico), 90-120 min: 13.8-28 % B (gradiente linear), 130-140 min: 28-100% B (gradiente linear).…”

Section: Fracionamento Da Fração Buoh-2 Por Clae-dad-prepunclassified

“…Não foi encontrado ocorrência de JGA-13 no gênero, enquanto que, para JGA-12, foi observada sua presença em P. incarnata, P. serratodigitata, P. serratifolia, P. foetida (GADIOLI et al, 2016) e P. quadrangulares (COSTA et al, 2013).…”

Section: Importância Farmacológica E Ocorrência Das Substâncias Isolaunclassified

“…3.2.9 Metodologia analítica para análise do extrato metanólico das folhas de Passiflora cincinnata por CLAE-DAD-IES-EM e CLAE-DAD-IES-IT-EM n A metodologia analítica foi desenvolvida baseada na proposta porCosta et al (2013).Em equipamento de CLAE-DAD-IES-IT-EM n , utilizando uma amostra das folhas de P.cincinnata preparada conforme descrito no item anterior. O método foi adaptado para as condições necessárias deste estudo.…”

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Passiflora L. (Passifloraceae): estudos fitoquímicos suportados no desenvolvimento de estratégias de cromatografia líquida acoplada à espectrometria de massas

Amaral¹

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, pelo exemplo de cientista e por todos os ensinamentos, orientações, oportunidades, incentivos e amizade. Obrigado pela confiança, você sempre fará parte da minha vida. A todos os professores do Núcleo de Pesquisa de Produtos Naturais e Sintéticos. Levo para sempre os seus ensinamentos. Ao Prof. Dr. Mateus Freire Leite e sua família, por todo incentivo, acolhimento e apoio na realização deste projeto. A amizade de vocês é um presente de Deus. Ao Dr. João Paulo Barreto de Sousa e sua esposa Lidiane Sousa, por toda atenção, amizade e carinho. Vocês são essenciais em nossa vida. Ao Prof. Me. Marcelo Reis da Costa, pelos ensinamentos e amizade fraterna.

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Bioactive compounds, functional properties, and technological application of Passiflora quadrangularis: A review

et al. 2023

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The objective of this research was to evaluate the bioactive compounds and functional properties of Passiflora quadrangularis, aiming to contribute to future studies on the elaboration of functional products based on this species. The chemical analysis of flavonoids from the leaves, as well as the chemical composition of fruits (specifically the pericarp) were accessed herein. The functional properties are directly dependent on specific extracts, and the aqueous extract and the flavonoid fraction are responsible for the sedative property. The presence of C‐glycosyl flavonoids is highly reported in the chemical composition, highlighting the vitexin‐2″‐O‐xyloside. Few studies have been focused on this species, and most of them are devoted to the sedative properties of the genus Passiflora spp. However, a review on the main available information on this species is of extreme interest for the research and development of products in pharmaceuticals, cosmetics, and food areas.

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VITEXIN DERIVATIVES AS CHEMICAL MARKERS IN THE DIFFERENTIATION OF THE CLOSELY RELATED SPECIES PASSIFLORA ALATA CURTIS AND PASSIFLORA QUADRANGULARIS LINN

Cited by 18 publications

References 15 publications

Assessment of Sedative Effects of Passiflora edulis f. flavicarpa and Passiflora alata Extracts in Mice, Measured by Telemetry

Assessment of Sedative Effects of Passiflora edulis f. flavicarpa and Passiflora alata Extracts in Mice, Measured by Telemetry

Passiflora L. (Passifloraceae): estudos fitoquímicos suportados no desenvolvimento de estratégias de cromatografia líquida acoplada à espectrometria de massas

Bioactive compounds, functional properties, and technological application of Passiflora quadrangularis: A review

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