Vitellogenin Induction by Xenobiotic Estrogens in the Red-Eared Turtle and African Clawed Frog

Palmer, Brent D.; Palmer, Sylvia K.

doi:10.2307/3432407

Cited by 28 publications

(32 citation statements)

References 48 publications

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“…In designing a bioassay for xenoestrogens, toxicologists and biologists have used the induction of Vtg and Zr -protein in male and juvenile oviparous vertebrates as an effective and sensitive biomarker for xenoestrogens [113-118]. Using juvenile Atlantic salmon ( Salmo salar ) and different doses of NP, we saw that NP treatment significantly elevated plasma levels of Zr-protein and Vtg in a two week in vivo study, with the former showing more sensitivity to the xenoestrogen compound [115].…”

Section: Molecular Mechanisms For Oogenic Protein Gene Expressionmentioning

confidence: 99%

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Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption

2003

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The oocyte is the starting point for a new generation. Most of the machinery for DNA and protein synthesis needed for the developing embryo is made autonomously by the fertilized oocyte. However, in fish and in many other oviparous vertebrates, the major constituents of the egg, i.e. yolk and eggshell proteins, are synthesized in the liver and transported to the oocyte for uptake. Vitellogenesis, the process of yolk protein (vitellogenin) synthesis, transport, and uptake into the oocyte, and zonagenesis, the synthesis of eggshell zona radiata proteins, their transport and deposition by the maturing oocyte, are important aspects of oogenesis. The many molecular events involved in these processes require tight, coordinated regulation that is under strict endocrine control, with the female sex steroid hormone estradiol-17β in a central role. The ability of many synthetic chemical compounds to mimic this estrogen can lead to unscheduled hepatic synthesis of vitellogenin and zona radiata proteins, with potentially detrimental effects to the adult, the egg, the developing embryo and, hence, to the recruitment to the fish population. This has led to the development of specific and sensitive assays for these proteins in fish, and the application of vitellogenin and zona radiata proteins as informative biomarkers for endocrine disrupting effects of chemicals and effluents using fish as test organisms. The genes encoding these important reproductive proteins are conserved in the animal kingdom and are products of several hundred million years of evolution.

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Section: Molecular Mechanisms For Oogenic Protein Gene Expressionmentioning

confidence: 99%

“…*Significantly different from control (p < 0.001). Reproduced with permission from Arukwe et al [113]. …”

Section: Molecular Mechanisms For Oogenic Protein Gene Expressionmentioning

confidence: 99%

Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption

2003

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“…Examples include o,p-DDT, which induced estrogen-mediated hepatic synthesis of the yolk precursor VTG in male red-eared turtles (Trachemys scripta) [139] and environmentally relevant concentrations of atrazine, which induced hermaphroditism at 0.1 parts per billion (ppb) in American leopard frogs (Rana pipiens) [140]. Examples include o,p-DDT, which induced estrogen-mediated hepatic synthesis of the yolk precursor VTG in male red-eared turtles (Trachemys scripta) [139] and environmentally relevant concentrations of atrazine, which induced hermaphroditism at 0.1 parts per billion (ppb) in American leopard frogs (Rana pipiens) [140].…”

Section: Reptiles and Amphibiansmentioning

confidence: 99%

Endocrine Disruption in Wildlife: Background, Effects, and Implications

Vethaak¹,

Legler²

2013

Endocrine Disrupters

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“…It is normally synthesized in the liver of adult nonmammalian female vertebrates in response to estrogenic stimulation. The livers of both reproductively immature females and males are able to synthesize and secrete VTG in response to estrogen stimulation [209][210][211]. Thus, VTG has been used as a biomarker for xenobiotic exposure to estrogenic compounds in fishes, turtles and amphibians for which in vivo and in vitro assays have been developed [212][213][214][215][216].…”

Section: 33mentioning

confidence: 99%