Analysis of steroidal estrogen residues in food and environmental samples

Wang, Shuo; Huang, Wei; Fang, Guozhen; Zhang, Yan; Qiao, Hui

doi:10.1080/03067310701597293

Cited by 26 publications

(7 citation statements)

References 223 publications

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“…In fact samples are often constituted by complicated matrices, where initially the compound of interest must be extracted from, then isolated, identified and quantified. Several analytical methods are nowadays available to detect estrogenic EDCs, depending on the nature of the sample to analyze (milk, meat, miscellaneous matrices, fish, packaging materials, etc) in a cost-effective way, and increasing efforts in finding more sensible and accurate analytical methods are currently underway (Adamusova et al, 2014; Capriotti et al, 2013; Wang et al, 2008; Kudlaka et al, 2015; Rotroff et al 2014). …”

Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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“…Because of the estrogen residues, there is a potential risk for wildlife and humans through the consumption of contaminated food or water. Chronic exposure is also of toxicological and will exhibit endocrine-disrupting effects on human beings [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Determination of three estrogens and bisphenol A by functional ionic liquid dispersive liquid-phase microextraction coupled with ultra-high performance liquid chromatography and ultraviolet detection

et al. 2015

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A hydroxyl-functionalized ionic liquid, 1-hydroxyethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, was employed in an improved dispersive liquid-phase microextraction method coupled with ultra high performance liquid chromatography for the enrichment and determination of three estrogens and bisphenol A in environmental water samples. The introduced hydroxyl group acted as the H-bond acceptor that dispersed the ionic liquid effectively in the aqueous phase without dispersive solvent or external force. Fourier transform infrared spectroscopy indicated that the hydroxyl group of the cation of the ionic liquid enhanced the combination of extractant and analytes through the formation of hydrogen bonds. The improvement of the extraction efficiency compared with that with the use of alkyl ionic liquid was proved by a comparison study. The main parameters including volume of extractant, temperature, pH, and extraction time were investigated. The calibration curves were linear in the range of 5.0-1000 μg/L for estrone, estradiol, and bisphenol A, and 10.0-1000 μg/L for estriol. The detection limits were in the range of 1.7-3.4 μg/L. The extraction efficiency was evaluated by enrichment factor that were between 85 and 129. The proposed method was proved to be simple, low cost, and environmentally friendly for the determination of the four endocrine disruptors in environmental water samples.

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“…China is the country with the highest consumption of contraceptive pills, which explains the high concentrations of E2 and EE2 in Chinese water bodies (Stanback, 1997). When these compounds enter the environment, they can cause male reproductive dysfunction in wildlife (Wang et al, 2008). Traditional water treatment processes, such as chlorination, coagulation and sedimentation do not adequately remove EDCs.…”

Section: Risk Assessment and Causality Analysismentioning

confidence: 99%

Assessment of source water contamination by estrogenic disrupting compounds in China

Jiang

Yan

et al. 2012

Journal of Environmental Sciences

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Detection of estrogenic disrupting compounds (EDCs) in drinking waters around China has led to rising concerns about health risks associated with these compounds. There is, however, a paucity of studies on the occurrence and identification of the main compounds responsible for this pollution in the source waters. To fill this void, we screened estrogenic activities of 23 source water samples from six main river systems in China, using a recombinant two-hybrid yeast assay. All sample extracts induced significant estrogenic activity, with E2 equivalents (EEQ) of raw water ranging from 0.08 to 2.40 ng/L. Additionally, 16 samples were selected for chemical analysis by gas chromatography-mass spectrometry. The EDCs of most concern, including estrone (E1), 17β-estradiol (E2), 17α-ethinylestradiol (EE2), estriol (E3), diethylstilbestrol (DES), estradiol valerate (EV), 4-t-octylphenol (4-t-OP), 4-nonylphenols (4-NP) and bisphenol A (BPA), were determined at concentrations of up to 2.98, 1.07, 2.67, 4.37, 2.52, 1.96, 89.52, 280.19 and 710.65 ng/L, respectively. Causality analysis, involving comparison of EEQ values from yeast assay and chemical analysis identified E2, EE2 and 4-NP as the main responsible compounds, accounting for the whole estrogenic activities (39.74% to 96.68%). The proposed approach using both chemical analysis and yeast assay could be used for the identification and evaluation of EDCs in source waters of China.

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Analysis of steroidal estrogen residues in food and environmental samples

Cited by 26 publications

References 223 publications

Risks and benefits related to alimentary exposure to xenoestrogens

Risks and benefits related to alimentary exposure to xenoestrogens

Determination of three estrogens and bisphenol A by functional ionic liquid dispersive liquid-phase microextraction coupled with ultra-high performance liquid chromatography and ultraviolet detection

Assessment of source water contamination by estrogenic disrupting compounds in China

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