Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Tardy, Anne Laure; Pouteau, Etienne; Márquez, Daniel; Yılmaz, Çetin; Scholey, Andrew

doi:10.3390/nu12010228

Cited by 229 publications

(169 citation statements)

References 188 publications

(234 reference statements)

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“…There are several metabolic pathways, most of which are located in the mitochondria, that are critical for brain and muscular functions affecting mental functions, such as cognitive and psychological processes, and physical activity. The brain, unlike muscle, is always highly metabolically active, as it consumes approximately 3.5 ml O 2 per minute and 100 g of tissue, while resting muscle consumes only 1 ml O 2 per minute and 100 g of tissue (Tardy et al, 2020). Therefore, the capacity for oxygen consumption of the brain may be a mechanism explaining why we identified that patients with schizophrenia present severe fatigue but not muscle weakness.…”

Section: Discussionmentioning

confidence: 84%

High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Alonso

Valiente-Pallejà

Verge

et al. 2020

Acta Neuropsychiatr.

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Objective: It has been hypothesized that neuropsychiatric symptoms, including psychosis, can be the result of a milder brain bioenergetic defect produced by mitochondrial dysfunction; however, mitochondrial dysfunction can be present in other organs or systems. The aim of the study was to investigate whether clinical conditions associated with mitochondrial disorders (CAMDs) were frequently present in schizophrenia. Methods: A previously used questionnaire regarding the CAMDs was administered to patients and controls in a direct interview with a trained psychiatrist. The frequencies of CAMDs in 164 patients with schizophrenia were compared to those in 156 age- and sex-matched controls. Results: Severe fatigue, seizures, constipation and diabetes were significantly more frequent in patients with schizophrenia than in control subjects and apparently not related to pharmacological treatment. Conclusion: The results of the present study suggest that multi-systemic mitochondrial dysfunction may be an underlying mechanism involved in schizophrenia.

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Section: Discussionmentioning

confidence: 84%

High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Alonso

Valiente-Pallejà

Verge

et al. 2020

Acta Neuropsychiatr.

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“…[50,51] Given the role of vitamin C in carnitine biosynthesis, an essential cofactor in long-chain fatty acid's transportation into the mitochondria, it plays a crucial role in energy production through betaoxidation, and insufficient vitamin C supply can be responsible for weakness, fatigue, or muscle aching . [52] Limitations of the study are as follows: food records used to assess participants' dietary compliance are not ideal for this purpose. Finding a suitable biomarker for adherence to dietary patterns, in particular, to the DMP, can be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of comprehensive dietary advice on the physical and mental health of patients with ulcerative colitis during the remission phase: a parallel randomized controlled clinical trial

Tamizifar

Arab

2020

International Journal of Food Properties

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The impact of food on physical and mental co-complications of ulcerative colitis (UC) has not been clearly defined. The current study aimed to evaluate the effects of a dietary modification program (DMP) on fatigue, mental health, quality of life, fasting blood glucose, and lipid profile of UC patients during the remission phase. To conduct this parallel, randomized controlled trial study, 80 UC patients were recruited and allocated randomly to an intervention or a control group. Participants were provided dietary guidelines in the form of an educational booklet and a dedicated diet that was recommended for use for 12 weeks. The DMP consisted of recommendations that participants eat often and little (4-6 times per day), consume foods at a balanced temperature, decrease consumption of spicy foods, decrease excess intake of fat, decrease simple carbohydrates and drink adequate fluids. Moreover, increase goodquality protein and eliminate dairy products in the presence of lactose intolerance. Furthermore, it included avoidance of margarine, limiting alcohol, caffeine, and commercially prepared foods such as fast foods, ready meals, and canned foods. Baseline and post-intervention measurements of primary and secondary outcomes were recorded for final analysis. Overall, 76 patients completed the study. The participants in the DMP group consumed higher amounts of protein, zinc, vitamin C, and D and lower amounts of dietary energy, carbohydrate, saturated fat, sodium, and lactose compared to the control group (all P values <.05). Recommendations to follow the DMP resulted in a significant improvement of fatigue and mental health (depression, anxiety, and stress) in the intervention group compared with usual recommendations and a significant increase in some aspects of quality of life, including bodily pain and general health (all P values <.05). No significant changes were found in fasting blood glucose and lipid profile (all P values >.05). The study suggests that there is likely to be a link between the provided dietary advice with physical and mental improvements. The effect of diet does not arise through the elimination or the addition of specific nutrients; rather, each food syndicate many nutrients that let for a synergistic or an antagonistic action when present in a certain composition.

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“…However, as many vitamins are extremely sensitive to temperature and easily degraded during food processing and storage, vitamin deficiencies may occur in certain populations, namely in vegans, in elderly individuals, as well as in disease states. While low vitamin levels have been associated with increased risk of cardiovascular disease, neurodegenerative disorders, and cancer, supplementation has been reported as beneficial [ 126 , 127 , 128 , 129 ], which is mainly owing to its antioxidant and anti-inflammatory effects, as well as relevant metabolic and immune functions.…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

2020

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Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients present a complex clinical picture that, in severe cases, evolves to respiratory, hepatic, gastrointestinal, and neurological complications, and eventually death. The underlying pathophysiological mechanisms are complex and multifactorial and have been summarized as a hyperresponse of the immune system that originates an inflammatory/cytokine storm. In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. Curiously, the same populations have been described as more prone to a gut microbiota (GM) dysbiosis profile. Intestinal microflora plays a major role in many metabolic and immune functions of the host, including to educate and strengthen the immune system to fight infections, namely of viral origin. Notably, recent studies suggest the existence of GM dysbiosis in COVID-19 patients. This review article highlights the interplay between the triad GM dysbiosis–immune hyperresponse–inflammation in the individual resilience/fragility to SARS-CoV-2 infection and presents the putative impact of pharmacological and nutraceutical approaches on the triumvirate, with focus on GM.

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Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Cited by 229 publications

References 188 publications

High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Effects of comprehensive dietary advice on the physical and mental health of patients with ulcerative colitis during the remission phase: a parallel randomized controlled clinical trial

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

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