High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Alonso, Yolanda; Valiente-Pallejà, Alba; Verge, Begoña; Vilella, Elisabet; Martorell, Lourdes

doi:10.1017/neu.2020.16

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Most studies have found that schizophrenic patients are more likely to have constipation symptoms than healthy people. The main reason is that schizophrenic patients can't control their living habits, and during hospitalization, they don't participate in activities for a long time, which leads to the decrease of body digestive function and eventually constipation [4][5] . Schizophrenia can be divided into positive symptoms and negative symptoms.…”

Section: Introductionmentioning

confidence: 99%

Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia

2022

FMSR

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Background: The aim of study was to explore the prevalence and clinical characteristics of constipation in Chinese inpatients with schizophrenia and analyze its risk factors. Methods: 806 schizophrenic patients in Shanghai were recruited to analyze the prevalence of constipation and the clinical characteristics of schizophrenic patients. According to whether the patients had constipation, they were divided into constipation group and normal group. The living conditions of the two groups were compared, and the risk factors of constipation were analyzed. Finally, the ROC curve was used to determine the predictive efficacy of the related factors on constipation, and the utilization of the risk factors Logistic regression analysis was used to determine the important factors of constipation. Results: The prevalence of constipation in Chinese schizophrenic patients was higher than that in the general population. The prevalence of mild constipation was 32.5% in 806 schizophrenic patients, and the prevalence of severe constipation was 20.9%. There was also gender difference in the prevalence of constipation in schizophrenic patients, among which the prevalence of female constipation was 17.6%, and that of male constipation was 9.9%. The dietary habits of patients also had a significant impact on the prevalence of constipation (P=0.001). Conclusion: The risk of constipation in female patients with schizophrenia is significantly higher than that in male patients. The incidence of constipation is related to gender, age, education level, negative symptoms, PANSS total score, smoking, exercise and drinking water. Gender, education level and daily smoking are important predictors of constipation.

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Section: Introductionmentioning

confidence: 99%

Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia

2022

FMSR

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Optometry in adults with microdeletion 22q11.2: The eye as a window to the brain

von Scheibler,

Appaji,

Berendschot

et al. 2023

Biomarkers in Neuropsychiatry

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Schizophrenia in Translation: Why the Eye?

Silverstein

Choi

Green

et al. 2022

Schizophrenia Bulletin

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Schizophrenia is increasingly recognized as a systemic disease, characterized by dysregulation in multiple physiological systems (eg, neural, cardiovascular, endocrine). Many of these changes are observed as early as the first psychotic episode, and in people at high risk for the disorder. Expanding the search for biomarkers of schizophrenia beyond genes, blood, and brain may allow for inexpensive, noninvasive, and objective markers of diagnosis, phenotype, treatment response, and prognosis. Several anatomic and physiologic aspects of the eye have shown promise as biomarkers of brain health in a range of neurological disorders, and of heart, kidney, endocrine, and other impairments in other medical conditions. In schizophrenia, thinning and volume loss in retinal neural layers have been observed, and are associated with illness progression, brain volume loss, and cognitive impairment. Retinal microvascular changes have also been observed. Abnormal pupil responses and corneal nerve disintegration are related to aspects of brain function and structure in schizophrenia. In addition, studying the eye can inform about emerging cardiovascular, neuroinflammatory, and metabolic diseases in people with early psychosis, and about the causes of several of the visual changes observed in the disorder. Application of the methods of oculomics, or eye-based biomarkers of non-ophthalmological pathology, to the treatment and study of schizophrenia has the potential to provide tools for patient monitoring and data-driven prediction, as well as for clarifying pathophysiology and course of illness. Given their demonstrated utility in neuropsychiatry, we recommend greater adoption of these tools for schizophrenia research and patient care.

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High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Cited by 4 publications

References 28 publications

Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia

Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia

Optometry in adults with microdeletion 22q11.2: The eye as a window to the brain

Schizophrenia in Translation: Why the Eye?

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