Vitamins and Cancer

Shamberger, Raymond J.

doi:10.1007/978-1-4684-4670-8_4

Cited by 2 publications

(1 citation statement)

References 192 publications

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“…Exposure of separated lymphocytes in vitro to vitamin C at doses greater than 200 mM did not offer protection but induced strand breakage [34]. Experiments on animals bearing tumours induced by chemical agents showed that after administration of vitamin C, the growth of some tumours was inhibited while that of others was unaffected and in a third group the tumour growth was enhanced [38]. Thus, the present and previously reported findings in the literature illustrate the complexity of the interactions of vitamin C in biological systems and indicate that with different concentrations and time of application in vivo or in vitro, vitamin C can cause or prevent genotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

Krishnaja

Sharma

2003

Teratog. Carcinog. Mutagen.

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Vitamin C (l-ascorbic acid), an effective free radical scavenger present as ascorbate in most biological systems, is one of the most extensively studied antioxidant vitamins. Vitamin C acts as either a free radical scavenger or a pro-oxidant producing hydrogen peroxide and free radicals. The modulatory effect of L-ascorbic acid (AA) on Mitomycin C (MMC) induced chromosome damage has been evaluated in human peripheral blood lymphocytes in vitro. The effect of L-ascorbic acid, 200 microg/ml as 1- and 2-h pretreatment on the frequencies of the biomarkers micronuclei (MN), sister chromatid exchanges (SCEs), and chromosome aberrations (CA) induced by mitomycin C 0.1 and 0.2 microg/ml has been studied. AA pretreatment caused a statistically significant increase in MMC-induced MN and SCE frequencies for all treatment groups, but did not show an increase in induced chromosome aberrations compared to MMC treatment alone. Cell division delays caused by MMC was reversed in the presence of AA. Interindividual variability in MMC as well as AA plus MMC-induced MN, SCE, and CA frequencies were evident. Ascorbic acid potentiated MMC-induced chromosome damage in human lymphocytes in vitro. The potentiation observed has to be viewed in the light of metal ion catalysed autooxidation of AA in oxygenated media and the existence of an antioxidant system in vivo that inactivates oxyradicals before their interaction with DNA.

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Section: Discussionmentioning

confidence: 99%

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

Krishnaja

Sharma

2003

Teratog. Carcinog. Mutagen.

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In Vitro Metabolism of Aflatoxin B₁ with Microsomal Enzymes in the Presence of Selected Nutrients

Wheeler

Harrison

Koehler

1987

Journal of Food Science

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High pressure liquid chromatography was used to evaluate the effects of several naturally occurring food components (selenium, vitamins A, E, B6 and C) on the in vitro metabolism of aflatoxin B, (AFB,). AFB, was incubated with a liver microsomal enzyme metabolizing system with varying concentrations of each nutrient. The following nutrients and levels either inhibited or reduced the metabolism of AFB,: sodium selenite (25 pg/mL), d-cY-tocopherol(25, 250 and 2500 FglmL), pyridoxine hydrochloride (2.5 PglmL), L-ascorbic acid (25 and 2500 pg/mL) and mixture containing 500 p,g/mL of each chemical. Retinol acetate at levels of 2.5 and 25 pg/mL increased the level of AFB 1 metabolized.

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Vitamins and Cancer

Cited by 2 publications

References 192 publications

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

In Vitro Metabolism of Aflatoxin B₁ with Microsomal Enzymes in the Presence of Selected Nutrients

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Vitamins and Cancer

Cited by 2 publications

References 192 publications

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro

In Vitro Metabolism of Aflatoxin B1 with Microsomal Enzymes in the Presence of Selected Nutrients

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In Vitro Metabolism of Aflatoxin B₁ with Microsomal Enzymes in the Presence of Selected Nutrients