Vitaminantagonismus

Lotze, Harald

doi:10.1007/bf01771923

Cited by 4 publications

(2 citation statements)

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“…This indeed may be the case. Antipyrine, aminopyrine, and related pyrazolones are commonly substituted, and we find that the same formidable list of nephrotoxic effects as seen with salicylates has in fact been encountered with the antipyrine group (Lotze, 1934;Aosima, 1940;Axelsson, 1958;Fazekas, Fazekas & Bertok, 1960;Eknoyan & Matson, 1964). The related anti-inflammatory drug phenylbutazone has similar nephrotoxic effects (Lipsett & Goldman, 1954;Steinbrocker, Neustadt & Ehrlich, 1954;Weisman & Bloom, 1955: Bruck, Fearnley, Meanock & Patley, 1954 in addition to other unpleasant effects such as agranulocytosis (see Gsell, 1954).…”

Section: Antipyrine Group and Other Anti-inflammatory Agentsmentioning

confidence: 63%

The nephrotoxicity of analgesics

1966

Journal of Pharmacy and Pharmacology

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IN recent years there has been increasing suspicion that prolonged or excessive use of analgesics may result in progressive renal damage very similar to that produced by chronic pyelonephritis. Phenacetin (acetophenetidin) has been widely incriminated as the offending drug, mainly because it was common to all the analgesic mixtures mentioned in the early reports. Histologically and functionally the renal lesions are predominantly tubular, with interstitial fibrosis, tubular degeneration and atrophy and a high incidence of papillary necrosis and pyelonephritis (Rubenstein, Abrahams, Stables & Levin, 1964).

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