Vitamin transporters in mice brain with aging

Marcos, Pilar; González-Fuentes, J.; Castro-Vázquez, L.; Lozano, M.; Santander-Ortega, Manuel J.; Robledo, Virginia Rodríguez; Villaseca-González, N.; Arroyo-Jiménez, M.M.

doi:10.1111/joa.12769

Cited by 12 publications

(7 citation statements)

References 45 publications

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“…The vitamin E carrier α-TTP is expressed in the liver, brain, and in utero [55,56], but we evidence its expression also in PBMCs and its modulation by calorie restriction and exercise. α-TTP has been shown to be a determinant of vitamin E level in tissues and in circulation [57,58]. Our results suggest that calorie restriction and exercise enhance the capabilities to incorporate vitamin E into PBMCs.…”

Section: Discussionmentioning

confidence: 59%

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

et al. 2020

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Our aim was to characterize the effects of calorie restriction on the anthropometric characteristics and physical performance of sportsmen and to evaluate the effects of calorie restriction and acute exercise on mitochondria energetics, oxidative stress, and inflammation. Twenty volunteer taekwondo practitioners undertook a calorie restriction of 30–40% on three alternate days a week for one month. Eleven volunteer sportsmen participated as controls. Both groups performed an energy efficiency test to evaluate physical performance, and samples were taken before and after exercise. The total weight of participants significantly decreased (5.9%) after calorie restriction, while the efficiency of work and the contributions of fat to obtain energy were enhanced by calorie restriction. No significant differences induced by acute exercise were observed in individual non-esterified fatty acid percentage or oxidative stress markers. Calorie restriction downregulated the basal gene expression of nitric oxide synthase, antioxidant enzymes, mitochondrial uncoupling proteins, and repairing stress proteins, but it enhanced the expression of sirtuins in peripheral blood mononuclear cells. In conclusion, one month of calorie restriction decreases body weight and increases physical performance, enhancing energy efficiency, moderating the antioxidant and inflammatory basal gene expression, and influencing its response to acute exercise.

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Section: Discussionmentioning

confidence: 59%

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

et al. 2020

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“…Thus, VitC and VitE are transported into neurons by different carrier proteins, and accumulated by separate systems that act synergically ( Spector and Johanson, 2007 ). A recent work ( Marcos et al, 2018 ) reports the brain distribution of SVCT2 and α-TTP, which display specific patterns that remain unchanged with age. Besides, they are present mainly in neurons but not in astrocytes, and this could contribute to explain the selective responses observed in neurons against OS ( Wang and Michaelis, 2010 ).…”

Section: Vitamins and Oxidative Stressmentioning

confidence: 99%

Neuroprotective Natural Molecules, From Food to Brain

et al. 2018

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The prevalence of neurodegenerative disorders is increasing; however, an effective neuroprotective treatment is still remaining. Nutrition plays an important role in neuroprotection as recently shown by epidemiological and biochemical studies which identified food components as promising therapeutic agents. Neuroprotection includes mechanisms such as activation of specific receptors, changes in enzymatic neuronal activity, and synthesis and secretion of different bioactive molecules. All these mechanisms are focused on preventing neuronal damage and alleviating the consequences of massive cell loss. Some neuropathological disorders selectively affect to particular neuronal populations, thus is important to know their neurochemical and anatomical properties in order to design effective therapies. Although the design of such treatments would be specific to neuronal groups sensible to damage, the effect would have an impact in the whole nervous system. The difficult overcoming of the blood brain barrier has hampered the development of efficient therapies for prevention or protection. This structure is a physical, enzymatic, and influx barrier that efficiently protects the brain from exogenous molecules. Therefore, the development of new strategies, like nanocarriers, that help to promote the access of neuroprotective molecules to the brain, is needed for providing more effective therapies for the disorders of the central nervous system (CNS). In order both to trace the success of these nanoplatforms on the release of the bioactive cargo in the CNS and determinate the concentration at trace levels of targets biomolecules by analytical chemistry and concretely separation instrumental techniques, constitute an essential tool. Currently, these techniques are used for the determination and identification of natural neuroprotective molecules in complex matrixes at different concentration levels. Separation techniques such as chromatography and capillary electrophoresis (CE), using optical and/or mass spectrometry (MS) detectors, provide multiples combinations for the quantitative and qualitative analysis at basal levels or higher concentrations of bioactive analytes in biological samples. Bearing this in mind, the development of food neuroprotective molecules as brain therapeutic agents is a complex task that requires the intimate collaboration and engagement of different disciplines for a successful outcome. In this sense, this work reviews the new advances achieved in the area toward a better understanding of the current state of the art and highlights promising approaches for brain neuroprotection.

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“…A recent work reports the brain distribution of SVCT2 and α-TTP, which display specific patterns that remain unchanged with age. Besides, they are present mainly in neurons but not in astrocytes, and this could contribute to explain the selective responses observed in neurons against OS [30][31][32].…”

Section: Results and Discussion Vitamins And Oxidative Stressmentioning

confidence: 99%

Biotechnology of Nanostructures Micronutrients Vitamins for Human Health

Madkour¹

2021

J NanoSci Res Rep

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Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. Micronutrients and nutraceuticals such as vitamins, carotenoids, polyunsaturated fatty acids and polyphenols are classes of food ingredients that are essential for human health and well-being. These compounds are rarely added purely to the targeted food application but rather in encapsulated, solid, dry product forms with added functionalities such as improved stability, bioavailability or handling. Development of new strategies, like nanocarriers, that help to promote the access of neuroprotective molecules to the brain, is needed for providing more effective therapies for the disorders of the central nervous system (CNS). Polymer–lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading and mucoadhesiveness were produced for potential nutraceutical and pharmaceutical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. Active targeting of nanoparticles loaded with vitamin D to cancer cells.

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Vitamin transporters in mice brain with aging

Cited by 12 publications

References 45 publications

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

Neuroprotective Natural Molecules, From Food to Brain

Biotechnology of Nanostructures Micronutrients Vitamins for Human Health

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