Vitamin <scp>D</scp> reduces the inflammatory response and restores glucose uptake in adipocytes

Marcotorchino, Julie; Gouranton, Erwan; Romier, Béatrice; Tourniaire, Franck; Astier, Julien; Malezet, Christiane; Amiot, Marie-Josèphe; Landrier, Jean‐François

doi:10.1002/mnfr.201200383

Cited by 134 publications

(128 citation statements)

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“…These results have since been challenged by several groups (67,(75)(76)(77) who consistently report anti-inflammatory effects of 1,25 (OH) 2 D whatever the model studied, which fits better with the well-described anti-inflammatory effect of VD in many other cell types (78) . Indeed, it was shown that 1,25(OH) 2 D significantly decreased the release of IL-8, monocyte chemoattractant protein (MCP)-1 and IL-6 by human preadipocytes (76) and MCP-1 by human adipocytes (75) .…”

Section: Regulation Of Inflammationmentioning

confidence: 76%

“…Similarly, 1,25(OH) 2 D reduced the expression of IL-6, IL-8 and MCP-1 in human adipose tissue biopsies submitted to IL-1β stimulation in vitro (79) . The molecular mechanisms have been investigated, and VDR and NF-κB signalling pathways and p38 mitogen-activated protein kinases were shown to be involved in 3T3-L1 adipocytes (67) . Interestingly, Zoico et al recently demonstrated that VD, similarly to 1,25(OH) 2 D, was able to blunt the lipopolysaccharide-mediated pro-inflammatory effect in human adipocytes (37) .…”

Section: Regulation Of Inflammationmentioning

confidence: 99%

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Vitamin D modulates adipose tissue biology: possible consequences for obesity?

et al. 2015

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Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD-obesity relationship.Adipose tissue: Vitamin D: Obesity: Inflammation: Adipocytes: Nutrients: Nutrition Vitamin D: a brief overview Vitamin D (VD; calciferol) is a hormone mainly described for its role as a regulator of phosphate and calcium homeostasis (1) . It can be obtained through animal (VD 3 , cholecalciferol) or plant (VD 2 , ergocalciferol) food sources. Only a few foodstuffs contain significant amounts of VD, the main sources being fish liver oils, fatty fish (sardines, herring and mackerel) and egg yolk (2,3) , but small quantities are also found in fortified milk, orange juice, bread and cereals. Alternatively, VD 3 is produced endogenously in the skin after UVB irradiation from the precursor 7-dehydrocholesterol to give pre-VD 3 , which is further isomerised to VD 3 before being released into the circulation (4) . Classical estimates have assigned a majority (70-90 %) of VD supply to dermal synthesis, but a recent paper revised this figure down to just 10-25 % of VD supply (5) and posited that dietary intake of 25-hydroxy-vitamin D (25(OH)D) is a significant contributor to total VD input.Adipose tissue is a major storage site for vitamin D Despite limited data, it is widely accepted that adipose tissue is a reservoir for VD in human subjects and rats (6)(7)(8)(9)(10) . Interestingly, visceral fat was found to contain 20 % more VD than subcutaneous fat (11) . Heaney et al. (12) calculated that 65 % of total VD in the body is in the form of D 3 , for which adipose tissue and skeletal muscle appear to be the main body stores (accounting for 73 and 16 %, respectively).

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Section: Regulation Of Inflammationmentioning

confidence: 76%

Section: Regulation Of Inflammationmentioning

confidence: 99%

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

et al. 2015

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“…Vitamin D receptors (VDR) present in adipocytes allow the suppression of Parathyroid hormone (PTH) levels. The PTH excess observed in menopausal women with both primary and secondary hyperparathyroidism may promote weight gain by impeding catecholamine-induced lipolysis [50]. A previous study showed that Vit D has a positive effect on muscle mass, especially on fat free mass, and also on muscle activity [4].…”

Section: Discussionmentioning

confidence: 99%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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Parvin Babaei, Arsalan Damirchi and Rastegar Hoseini. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. Vol. 19, No. 3, pp.173-182, 2015 [Purpose] The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.[Methods] Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.[Results] Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.[Conclusion] It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

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“…VDR variant BsmI may impact the binding of 1,25(OH) 2 D 3 to VDR and further could mediate a mass of downstream effects on VDR-responsive genes. The effect of VDR Bsm1 variant polymorphism could be direct mediating effects through the immune system and inflammatory pathway by alteration of the inflammation is possibly resulting from the gut microbial translocation [13,27]. In addition, The BsmI, and TaqI polymorphism are located in the 3' untranslated region (3′ UTR) of the VDR gene.…”

Section: Discussionmentioning

confidence: 99%

“…All anthropometric measurements were evaluated in the Nutrition DepartmentQatar University by trained instructors. BMI categorized into the following categories: underweight (<18.5), normal weight (18.5-24.9), overweight (25)(26)(27)(28)(29)(30), and obese (>30) [19], % body fat for females >30% is used as a cut-off point to define obesity [20] and if waist circumference (WC) >88cm is used to define central obesity [21]. The homeostatic model assessment (HOMA) is used to quantify insulin resistance and beta-cell function, whereas HOMA-IR=[Glucose in mmol/l] * [Insulin in mU/L]/22.5 [22].…”

Section: Adiposity Phenotype Measurementsmentioning

confidence: 99%

Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

Sharif¹,

Swaidan²,

Shurbaji³

et al. 2016

EMIJ

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Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas obesity prevalence is increasing dramatically, only a few studies were addressed this relation with obesity based only on body mass index. This study aimed to find the association between three different VDR polymorphisms BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) BsmI, with the adiposity phenotypes (BMI, body fat BF% and waist circumference (WC) as a marker of visceral obesity.

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Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes

Cited by 134 publications

References 45 publications

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

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