Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

Sharif, Elham; Swaidan, Nuha; Shurbaji, Samar; Rizk, Nasser

doi:10.15406/emij.2016.03.00069

Cited by 3 publications

(1 citation statement)

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“…Minor allele carriers of the SNP BsmI (rs1544410) were at higher risk of an increased BMI, and BsmI gene polymorphism was more frequent in obese individuals of arabian people showed by the previous studies [17,18]. Contrary to the study of Sharife et al [17], individuals carrying the major allele (G) of the Bsm I gene were at risk of obesity in a study conducted in North China [19]. Wang et al [20] genotyped Cdx2, BsmI, TaqI, ApaI, and FokI in the VDR gene of 106 overweight/obese and 86 healthy control Chinese children to search association of VDR with MetS.…”

Section: Discussionmentioning

confidence: 75%

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

Özhan

BİLGİHAN²,

Cetin

et al. 2023

Pam Tıp Derg

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Purpose: The aim of study was to determine the relation of vitamin D receptor gene (VDR) polymorphisms of TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with the risk of obesity, metabolic syndrome and hepatosteatosis in children.Materials and methods: 130 obese and 130 healthy children of age range between 10-16 years included in this study. Anthropometric measurements, biochemical evaluations and abdominal USG of all children were done. Obese and healty children were analyzed for the most common polymorphisms of the VDR gene by restriction fragment length polymorphism’s technique. The diagnosis of metabolic syndrome was made using the International Diabetes Federation criteria.Results: Genotypic distribution of BsmI, FokI, and TaqI polymorphism were found statistically different between obese patients and control group, but genotypic distribution of all studied polymorphisms were not found statistically different in obese patients with metabolic syndrome or hepatosteotosis. Conclusion: BsmI polymorphism (rs1544410) was found to have a significant positive effect on the development of obesity, metabolic syndrome and hepatosteatosis. Children who carry risk factors for childhood obesity could be screened before the development of obesity and associated metabolic complications using the BsmI polymorphism of the VDR gene.

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Section: Discussionmentioning

confidence: 75%

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

Özhan

BİLGİHAN²,

Cetin

et al. 2023

Pam Tıp Derg

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Establishing a genetic link between FTO and VDR gene polymorphisms and obesity in the Emirati population

et al. 2018

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BackgroundObesity is a metabolic disease that is widely prevalent with approximately 600 million people classified as obese worldwide. Its etiology is multifactorial and involves a complex interplay between genes and the environment. Over the past few decades, obesity rates among the Emirati population have been increasing. The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population.MethodsThis is a case-control study in which genomic DNA was extracted from saliva samples of 201 obese, 115 overweight, and 98 normal subjects in the United Arab Emirates (UAE). Genotyping for the variants was performed using TaqMan assay.ResultsThe mean Body Mass Index (BMI) ± SD for the obese, overweight, and normal subjects was 35.76 ± 4.54, 27.53 ± 1.45, and 22.69 ± 1.84 kg/m2, respectively. Increasing BMI values were associated with increase in values of HbA1c, systolic and diastolic blood pressure. There was a significant association observed between the FTO SNP rs9939609 and BMI (p = 0.028), with the minor allele A having a clear additive effect on BMI values. There was no significant association detected between BMI and rs1544410 of VDR. Moreover, significant interaction between the FTO rs9939609 and physical activity reduced the “AA” genotype effect on increase in BMI (p = 0.027).ConclusionsOur study findings indicate that the minor allele A of the rs9939609 has a significant association with increasing BMI values. Moreover, our findings support the fact that increasing BMI is associated with increasing risks of other comorbidities such as higher blood pressure, poorer glycemic control, and higher triglycerides. In addition, physical activity was found to attenuate the effect of the “AA” genotype on the predisposition to higher BMI values.

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Vitamin D Deficiency in Various Forms of Metabolic Syndrome in Women of Early and Active Reproductive Age

Татарчук¹,

Косей²,

Регеда³

et al. 2020

Scientific Digest of Association of Obstetricians and Gynecologists of Ukraine

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Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

Cited by 3 publications

References 33 publications

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

Establishing a genetic link between FTO and VDR gene polymorphisms and obesity in the Emirati population

Vitamin D Deficiency in Various Forms of Metabolic Syndrome in Women of Early and Active Reproductive Age

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