Vitamin <scp>D</scp> levels in patients with <scp>B</scp>ehçet's disease

Balta, İlknur; Balta, Şevket; Demırkol, Sait; Demır, Mustafa; Çelik, Turgay

doi:10.1111/1756-185x.12236

Cited by 3 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…Insufficient vitamin D levels were detected in many chronic illnesses, including coronary artery disease, 2 diabetes mellitus, 3 systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, psoriasis, malignancy, autoimmune, infectious diseases, and Behcet's disease. 4 Furthermore, smoking, alcohol intake were related the low vitamin D levels. The vitamin D values are significantly lower in psoriatic patients than in control subjects.…”

Section: Dear Editormentioning

confidence: 99%

Vitamin D Levels in Patients with Atrial Fibrillation

Balta

Öztürk

Demırkol

et al. 2016

Noninvasive Electrocardiol

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Section: Dear Editormentioning

confidence: 99%

Vitamin D Levels in Patients with Atrial Fibrillation

Balta

Öztürk

Demırkol

et al. 2016

Noninvasive Electrocardiol

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“…Because of these and other associated immunomodulating effects (Leventis and Patel 2008), and the known potential role of alterations in vitamin D receptors and BD occurrence (i.e. Kolahi et al 2015) as well as the importance of maintaining vitamin D levels in BD patients (Balta et al 2014;Khabbazi et al 2014), vitamin D supplementation has increasingly been evaluated to treat these patients, in particular, with regard to helping endothelial cells regain somewhat normal functionalities (Can et al 2012;Gungor et al 2016). In these studies, it was seen that the use of the vitamin did help to mitigate vascular dysfunctionality, although the authors cautioned this regimen could not be considered a primary treatment modality.…”

Section: Dapsone 100 Mg/d 3 Momentioning

confidence: 99%

Genetics and immunodysfunction underlying Behçet’s disease and immunomodulant treatment approaches

Salmaninejad

Gowhari

Hosseini

et al. 2017

Journal of Immunotoxicology

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Behçet's disease (BD) is a chronic autoimmune condition primarily prevalent in populations along the Mediterranean Sea. The exact etiology of BD has not been fully explained yet, but the disease occurrence is associated with a genetic factor, human leukocyte antigen (HLA)-B51 antigen. Among the various immunodysfunctions that are found in BD, patients are increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin (IL)-10. Elevated levels of inflammatory cytokines like IL-1 and IL-17 in BD have been found associated with aberrant expression of microRNA. Gene polymorphisms in BD patients have been observed in molecules involved in responses to pathogens that can ultimately modulate the host antimicrobial response. Moreover, several single nucleotide polymorphisms (SNPs) have been reported in genes encoding chemokines and adhesion molecules; many of these changes manifest as increases in vascular inflammation and vascular damage. Lastly, genetic and epigenetic changes have been suggested as involved in the pathogenesis of BD. Modifications in DNA methylation have been found in BD patient monocytes and lymphocytes, leading to adverse function of these cells. This review presents a comprehensive compilation of the literature with regard to the immunodysfunction underlying BD, as well as of the genetics, newly described clinical specifications and novel treatment strategies using immunomodulants based on the current understanding of BD.

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