Vitamin K stimulation of sphingolipid synthesis

Lev, M.; Milford, Albert F.

doi:10.1016/0006-291x(71)90826-6

Cited by 22 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Radio thin-layer chromatography was carried out with a Packard radio thin-layer or a Berthold scanner. Radioactive precursors [1][2][3][4][5][6][7][8][9][10][11][12][13][14] …”

Section: Methodsmentioning

confidence: 99%

“…Its three components, the longchain base (4r-sphingenine), fatty acids (a-hydroxy fatty acids) and the hexose (glucose) were identical in the medium and in the Bacteroides lipids. [6,7,9, '//]-palmitic acid [l-14 C]Palmitic acid (20.4 μηιοί spec, radioact. 0.854 μΟ/μιηοΙ) was added as an alcohol solution (100 μ/) to 1 / of Bacteroides thet.…”

Section: / Analytical Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Sphingolipid Metabolism inBacteroideaceae

Stoffel¹,

Dittmar²,

Wilmes³

1975

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

View full text Add to dashboard Cite

The lipid composition of the anaerobic Bacteroides thetaiotaomikron has been analyzed. Sphingomyelin, ceramide phosphinicoethanolamine, free even-numbered and branched chain sphingosine bases and ceramide represented about 50% of the total lipid extract. The main ester phospholipid was phosphatidylethanolamine.The alkali-stable sphingophospholipids were predominantly ./V-acylated with 3-hydroxypalmitic acid, whereas the ester phospholipids are preferentially substituted with normal even and odd-numbered and branched-chain fatty acids.

show abstract

“…Radio thin-layer chromatography was carried out with a Packard radio thin-layer or a Berthold scanner. Radioactive precursors [1][2][3][4][5][6][7][8][9][10][11][12][13][14] …”

Section: Methodsmentioning

confidence: 99%

Section: / Analytical Studiesmentioning

confidence: 99%

Sphingolipid Metabolism inBacteroideaceae

Stoffel¹,

Dittmar²,

Wilmes³

1975

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

View full text Add to dashboard Cite

show abstract

“…A role for vitamin K in sphingolipids was initially demonstrated in bacteria, where it was found to be essential to cell membrane structure [40,41]. The action of vitamin K resided in its induction of 3-ketodihydrosphingosine (3-KDS) synthase, the enzyme involved in the initial step of sphingolipid biosynthesis [42].…”

Section: Vitamin K and Sphingolipid Metabolismmentioning

confidence: 99%

Vitamin K, an emerging nutrient in brain function

Ferland

2012

BioFactors

View full text Add to dashboard Cite

Historically discovered for its role in blood coagulation, there is now convincing evidence that vitamin K has important actions in the nervous system. As a unique cofactor to the γ-glutamyl carboxylase enzyme, vitamin K contributes to the biological activation of proteins Gas6 and protein S, ligands for the receptor tyrosine kinases of the TAM family (Tyro3, Axl, and Mer). Functionally, Gas6 has been involved in a wide range of cellular processes that include cell growth, survival, and apoptosis. In brain, vitamin K also participates in the synthesis of sphingolipids, an important class of lipids present in high concentrations in brain cell membranes. In addition to their structural role, sphingolipids are now known to partake in important cellular events such as proliferation, differentiation, senescence and cell-cell interactions. In recent years, studies have linked alterations in sphingolipid metabolism to age-related cognitive decline and neurodegenerative diseases such as Alzheimer's disease (AD). Emerging data also point to unique actions of the K vitamer menaquinone-4 (MK-4) against oxidative stress and inflammation. Finally, there is now data to suggest that vitamin K has the potential to influence psychomotor behavior and cognition. This review presents an overview of what is known of the role of vitamin K in brain function.

show abstract

“…98 This role of vitamin K also appears to be organ specific, because warfarin decreased galactosyl-ceramide sulfate transferase activity in the brain but not in other sulfatiderich organs, such as kidney or spleen. 98 In vitro studies 17,95,99 compared the effects of menadione and phylloquinone on sphingolipid metabolism but not MK-4, which is the predominant form of vitamin K in the brain. Vitamin K administered in the form of MK-4 has since been reported to also have a stimulatory effect on sulfatide levels and galactosyl-ceramide sulfate transferase activity in mice and rats.…”

Section: Vitamin K and Sphingolipid Metabolismmentioning

confidence: 99%

Vitamin K and Sphingolipid Metabolism: Evidence to Date

Denisova

Booth

2005

Nutrition Reviews

View full text Add to dashboard Cite

The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date suggest a role of vitamin K in the regulation of multiple enzymes involved in sphingolipid metabolism within the myelin-rich regions in the brain. However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied.

show abstract

Vitamin K stimulation of sphingolipid synthesis

Cited by 22 publications

References 7 publications

Sphingolipid Metabolism inBacteroideaceae

Sphingolipid Metabolism inBacteroideaceae

Vitamin K, an emerging nutrient in brain function

Vitamin K and Sphingolipid Metabolism: Evidence to Date

Contact Info

Product

Resources

About