Vitamin K and Sphingolipid Metabolism: Evidence to Date

Denisova, Natalia A.; Booth, Sarah L.

doi:10.1111/j.1753-4887.2005.tb00129.x

Cited by 50 publications

(29 citation statements)

References 105 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of MK-4 in myelin fractions, and the positive correlations between MK-4 and sulfatides in brain myelin, supports recent findings in female rats [31] suggests the physiological role of MK-4 may be independent from its well-known role as a cofactor for the γ-carboxylation reactions [30, 34, 46]. It is currently not known whether long-term dietary dihydrophylloquinone consumption will modulate these functions through further reduction in dK conversion to MK-4, and whether MK-4 may have a role in myelin formation and maintenance.…”

Section: Discussionsupporting

confidence: 83%

“…Vitamin K, a fat-soluble vitamin, has been implicated in regulation of brain sphingolipid metabolism, including sulfatide metabolism [28, 29, 30]. Furthermore, a recent study reported a positive correlation between sulfatides and vitamin K, which is present almost exclusively in the form of menaquinone-4 (MK-4) in the brain [31, 32].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a recent study reported a positive correlation between sulfatides and vitamin K, which is present almost exclusively in the form of menaquinone-4 (MK-4) in the brain [31, 32]. However, there are inconsistencies on the putative role of vitamin K on sulfatides, as reviewed elsewhere [30]. To the best of our knowledge the dietary effect of vitamin K on brain myelin was not investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Crivello

Casseus

Peterson

et al. 2010

The Journal of Nutritional Biochemistry

Self Cite

View full text Add to dashboard Cite

Dysregulation of myelin sulfatides is a risk factor for cognitive decline with age. Vitamin K is present in high concentrations in the brain and has been implicated in the regulation of sulfatide metabolism. Our objective was to investigate the age-related interrelation between dietary vitamin K and sulfatides in myelin fractions isolated from the brain regions of Fischer 344 male rats fed one of two dietary forms of vitamin K: phylloquinone or its hydrogenated form, dihydrophylloquinone for 28 days. Both dietary forms of vitamin K were converted to menaquinone-4 in the brain. The efficiency of dietary dihydrophylloquinone conversion to menaquinone-4 compared to dietary phylloquinone was lower in the striatum and cortex, and was similar to those in the hippocampus. There were significant positive correlations between sulfatides and menaquinone-4 in the hippocampus (phylloquinonesupplemented diet -12mo and 24mo; dihydrophylloquinone -supplemented diet -12mo) and cortex (phylloquinone-supplemented diet -12mo and 24 mo). No significant correlations were observed in the striatum. Furthermore, sulfatides in the hippocampus were significantly positively correlated with MK-4 in serum. This is the first attempt to establish and characterize a novel animal model that exploits the inability of dietary dihydrophylloquinone to convert to brain menaquinone-4 to study the dietary effects of vitamin K on brain sulfatide in brain regions controlling motor and cognitive functions. Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure, and behavior functions.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Crivello

Casseus

Peterson

et al. 2010

The Journal of Nutritional Biochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…21 Studies with animals support a role for vitamin K in the biosynthesis of sphingolipids which are present in high concentration in the brain. [22][23][24] Although originally known for their role as a structural component of cell membrane, now sphingolipids are known to participate in cell signaling, proliferation, differentiation and survival.…”

Section: Warfarin Teratogenicitymentioning

confidence: 99%

Neurological sequelae of intrauterine warfarin exposure

Raghav

Reutens

2007

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…2007). The brain has high concentrations of vitamin K (Denisova and Booth 2005), which is essential for the development and many of the functions of the mammalian CNS (Tsaioun 1999; Funakoshi et al. 2002).…”

Section: Fat‐soluble Vitaminsmentioning

confidence: 99%

Vitamin‐regulated cytokines and growth factors in the CNS and elsewhere

Scalabrino

2009

Journal of Neurochemistry

View full text Add to dashboard Cite

There is a growing awareness that natural vitamins (with the only exception of pantothenic acid) positively or negatively modulate the synthesis of some cytokines and growth factors in the CNS, and various mammalian cells and organs. As natural vitamins are micronutrients in the human diet, studying their effects can be considered a part of nutritional genomics or nutrigenomics. A given vitamin selectively modifies the synthesis of only a few cytokines and/or growth factors, although the same cytokine and/or growth factor may be regulated by more than one vitamin. These effects seem to be independent of the effects of vitamins as coenzymes and/or reducing agents, and seem to occur mainly at genomic and/or epigenetic level, and/or by modulating NF‐κB activity. Although most of the studies reviewed here have been based on cultured cell lines, but their findings have been confirmed by some key in vivo studies. The CNS seems to be particularly involved and is severely affected by most avitaminoses, especially in the case of vitamin B12. However, the vitamin‐induced changes in cytokine and growth factor synthesis may initiate a cascade of events that can affect the function, differentiation, and morphology of the cells and/or structures not only in the CNS, but also elsewhere because most natural vitamins, cytokines, and growth factors cross the blood–brain barrier. As cytokines are essential to CNS‐immune and CNS‐hormone system communications, natural vitamins also interact with these circuits. Further studies of such vitamin‐mediated effects could lead to vitamins being used for the treatment of diseases which, although not true avitaminoses, involve an imbalance in cytokine and/or growth factor synthesis.

show abstract

Vitamin K and Sphingolipid Metabolism: Evidence to Date

Cited by 50 publications

References 105 publications

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Neurological sequelae of intrauterine warfarin exposure

Vitamin‐regulated cytokines and growth factors in the CNS and elsewhere

Contact Info

Product

Resources

About