Vitamin K in Treatment of Acute Hepatitis

Mossberg, Hans-Olof

doi:10.1136/bmj.1.4773.1382

Cited by 5 publications

(1 citation statement)

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“…The surface activity of such constructs may play an important role in drug delivery and targeting, as a high affinity for membranes relative to native proteins has been strongly implicated in the activity of drugs based on intermediately folded protein states. 46,47 The emergent qualities of BSA-Aunps must stem from how the protein exposes its hydrophobic motifs to the solvent. The exact details of the conformational changes are beyond both the scope of this study and the resolution of the applied techniques.…”

Section: Discussionmentioning

confidence: 99%

Emergent membrane-affecting properties of BSA–gold nanoparticle constructs

et al. 2011

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By adsorbing bovine serum albumin (BSA) on gold nanoparticles (Aunps) with diameters 30 nm and 80 nm, different degrees of protein unfolding were obtained. Adsorption and adlayer conformation were characterized by UV-vis spectroscopy, ζ-potential measurements, steady-state and time-resolved fluorescence. The unfolding was also studied using 1-anilino-8-naphthalene sulfonate (ANS) as an extrinsic probe, showing that BSA unfolds more on 80 nm Aunp than on 30 nm Aunp. Langmuir monolayer studies using two distinct methods of introducing the BSA and BSA-Aunp constructs accompanied with Brewster Angle Microscopy (BAM) and Digital Video Microscope (DVM) imaging demonstrated that BSA-Aunp constructs induce film miscibility with L-α-phosphatidylethanolamine not seen for BSA or Aunp alone. The changes induced by partial unfolding clearly give better film-penetration ability, as well as disruption of liquid crystalline domains in the film, thereby inducing film miscibility. Gold or protein only does not possess the nanoscale film-affecting properties of the protein-gold constructs, and as such the surface-active and miscibility-affecting characteristics of the BSA-Aunp represent emergent qualities.

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Section: Discussionmentioning

confidence: 99%

Emergent membrane-affecting properties of BSA–gold nanoparticle constructs

et al. 2011

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Recent Advances in Nutrition and Metabolism

Unglaub¹

1954

AMA Arch Intern Med

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A SMALL monograph entitled "Present Knowledge in Nutrition" has been published recently.1 This should prove a most useful reference ; sections dealing with calories, protein, fat, carbohydrate, minerals, and vitamins are included. VITAMIN A Cama and associates * reported further studies of the characteristics of vitamin A and related compounds. Kaiser and Kagan 6 have described a technique for the determination of vitamin A in feces.Prolonged administration of quinacrine (Atabrine) to rats was found to result in damage to the liver and impairment of the ability of this organ to store vitamin A. Absorption of vitamin A and carotene was depressed by the drug.7The administration of excessive amounts of vitamin A to rats and other animals accelerates the growth and maturation of epiphyseal cartilage cells and the remodeling process which accompanies bone growth. Such effects are suggestive of hormonal action, possibly that of the anterior pituitary. However, studies by Wolbach and Maddock 8 in hypophysectomized rats have shown that these effects occur in the absence of the pituitary and in spite of marked atrophy of the adrenal glands. Similar effects have been observed upon the addition of excessive amounts of vitamin A to the medium containing tissue culture of bone from chick embryos.9 The changes observed in tissue culture are qualitatively similar to those seen in animals made hypervitaminotic by feeding large amounts of vitamin A.f The use of tissue culture techniques appears to offer distinct advantages in the study of the effects of vitamin A upon tissues.14 An unusual case of vitamin A deficiency in a 5 J^-month-old infant was reported by Cornfeld and Cooke.15 Facial palsy and increased intracranial pressure observed in this patient might possibly be attributed to compression of tissues of the growing central nervous system by failure of normal growth of the axial skeleton, which has been observed in various mammalian species and, more recently, in the chicken and duck.| weeks. Definite beneficial effects of this therapy upon localized conjunctival thickening, blepharoconjunctivitis, and "toad skin" were observed. Follicular hyperkeratosis of the forearms persisted in five of eight patients, and improvement in dark adaptation was observed in only 4 of 17 subjects. Kaser and associates 1T reported that patients with a sprue-like syndrome showed no increase in serum vitamin A levels after oral administration of the vitamin given in either the ester or the alcohol form. Patients with chronic pancreatic disease showed no change in serum levels of the vitamin after administration of its ester form, but they were found to have an increase in serum vitamin A after administra¬ tion of the alcohol form.Steigmann and co-workers 18 confirmed the previously reported interference with absorption of vitamin A by mineral oil given close to mealtimes. However, the usual therapeutic dose (30 cc.) of the oil given at bedtime was without effect upon plasma vitamin A levels.Kagan and Kaiser 19 found high concentrations of v...

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Lebererkrankungen im Kindesalter

Ewerbeck

1955

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

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Vitamin K in Treatment of Acute Hepatitis

Cited by 5 publications

References 1 publication

Emergent membrane-affecting properties of BSA–gold nanoparticle constructs

Emergent membrane-affecting properties of BSA–gold nanoparticle constructs

Recent Advances in Nutrition and Metabolism

Lebererkrankungen im Kindesalter

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