Vitamin E Supplementation, Cardiovascular Events, and Cancer

A selective hybrid fluorescent sensor for fructose detection based on a phenylboronic acid and BODIPY-based hydrophobicity probe

“…In particular, fructose is a potent reducing sugar and may be involved in aging, atherosclerosis, and pathogenesis of the vascular, renal, and ocular complications of diabetes by producing toxic advanced glycation end-products. 2 Furthermore, regarding obesity and NAFLD, the prevalence of these diseases did not improve even with a decrease in the percentage of calories ingested from saturated fatty acids, suggesting other dietary or environmental factors, and fructose can be one of the candidates of a leading factor of several metabolic disorders such as NAFLD 3,4 and cardiometabolic disease. 5 In addition, fructose has been suggested as a potential factor with adverse effects on blood pressure, hypertension, inflammation, 6 and bowel disturbances.…”

“…5 In addition, fructose has been suggested as a potential factor with adverse effects on blood pressure, hypertension, inflammation, 6 and bowel disturbances. 2,7 Therefore, a simple method for quickly detecting fructose would be beneficial and stimulate a wide range of research in this field. The quantitative detections of fructose have typically been achieved by the specificity of the enzymes 8 or the chemical selectivity of phenylboronic acid (PB) as PB can covalently bond with cis -1,2- or 1,3-diol to form five- or six-membered cyclic boronic esters.…”

Tunable GLUT–Hexose Binding and Transport via Modulation of Hexose C‐3 Hydrogen‐Bonding Capabilities

“…GLUTs differ from each other in their substrate specificity and transport kinetic properties . Recent studies have suggested that GLUTs play a major role in several diseases, including but not limited to various cancer types, diabetes, and obesity . In addition, GLUTs are often overexpressed in tumor cells, and thereby have been used as portals for tracer molecules and anticancer drugs to enter the target cancer cells in a selective fashion .…”

Self‐assembly of Two Cobalt(II) Coordination Polymers Derived from Tetrabromoterephthalate and Flexible Bis(Benzimidazole) Co‐ligands

“…Glucose analogues such as 2‐deoxy‐2‐( 18 F)fluoro‐ D ‐glucose are established PET imaging agents 5. Now, however, fructose analogues and fructose uptake inhibitors are also becoming targets of interest, due to fructose's potential role in aggressive tumor growth and metabolic syndrome 1b. The first 1‐deoxy‐1‐( 18 F)fluoro‐fructose analogue (compound 1 , Scheme ), produced by Maeda and co‐workers, showed little specificity for tissue expressing fructose transporters 6.…”